可遗传性肺动脉高压是临床上少见的一种动脉型肺动脉高压,常表现为进行性加重的劳力性呼吸困难,目前尚无特效药物。现报道本院收治的1例可遗传性肺动脉高压患者,该患者存在骨形成蛋白受体2(bone morphogenetic protein 2,BMPR2)基因突变...可遗传性肺动脉高压是临床上少见的一种动脉型肺动脉高压,常表现为进行性加重的劳力性呼吸困难,目前尚无特效药物。现报道本院收治的1例可遗传性肺动脉高压患者,该患者存在骨形成蛋白受体2(bone morphogenetic protein 2,BMPR2)基因突变,口服伊马替尼100 mg,1次/d,治疗45个月后,临床症状和血流动力学均明显改善,未见明显不良反应。本文对该例临床特点进行总结并整理相关文献报道,尝试为临床提供治疗肺动脉高压的其他可行方案。展开更多
Graft can induce inheritable variations in the progenies of the scion plants. Seedling of mungbean ( Vigna radiata (L.) Wilczek) was grafted onto the stem of sweet potato ( Ipomoea batatas (L.) Lam.). The growth...Graft can induce inheritable variations in the progenies of the scion plants. Seedling of mungbean ( Vigna radiata (L.) Wilczek) was grafted onto the stem of sweet potato ( Ipomoea batatas (L.) Lam.). The growth of the scion was maintained until the scion produced selfed seeds. We sowed the seeds for several generations under normal conditions. Distinct genetic variations appeared in the progenies. Similar variations did not appear in the generations of the scion sowed normally without graft. The variations seemed to be induced by the graft and they inherited steadily. For understanding the possible mechanism of the phenomenon (graft_induced inheritable variation), we analyzed the cytoplasmic and genomic DNA of the variations. The results showed that there was no restriction fragment length polymorphism (RFLP) in the cytoplasmic DNA between the original scion and the variation. However, significant difference between the scion and variation was recognized by random amplified polymorphic DNA (RAPD) analysis. In addition, there was no evidence that indicated the gene transformation from stock to scion. Our results suggest that the non_specific grafting has a pragmatic potential for plant breeding and crop improvement and, the genetic variation seems not to be caused simply by DNA transformation but most likely the stress induced mutation.展开更多
文摘可遗传性肺动脉高压是临床上少见的一种动脉型肺动脉高压,常表现为进行性加重的劳力性呼吸困难,目前尚无特效药物。现报道本院收治的1例可遗传性肺动脉高压患者,该患者存在骨形成蛋白受体2(bone morphogenetic protein 2,BMPR2)基因突变,口服伊马替尼100 mg,1次/d,治疗45个月后,临床症状和血流动力学均明显改善,未见明显不良反应。本文对该例临床特点进行总结并整理相关文献报道,尝试为临床提供治疗肺动脉高压的其他可行方案。
文摘Graft can induce inheritable variations in the progenies of the scion plants. Seedling of mungbean ( Vigna radiata (L.) Wilczek) was grafted onto the stem of sweet potato ( Ipomoea batatas (L.) Lam.). The growth of the scion was maintained until the scion produced selfed seeds. We sowed the seeds for several generations under normal conditions. Distinct genetic variations appeared in the progenies. Similar variations did not appear in the generations of the scion sowed normally without graft. The variations seemed to be induced by the graft and they inherited steadily. For understanding the possible mechanism of the phenomenon (graft_induced inheritable variation), we analyzed the cytoplasmic and genomic DNA of the variations. The results showed that there was no restriction fragment length polymorphism (RFLP) in the cytoplasmic DNA between the original scion and the variation. However, significant difference between the scion and variation was recognized by random amplified polymorphic DNA (RAPD) analysis. In addition, there was no evidence that indicated the gene transformation from stock to scion. Our results suggest that the non_specific grafting has a pragmatic potential for plant breeding and crop improvement and, the genetic variation seems not to be caused simply by DNA transformation but most likely the stress induced mutation.
