The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3＇ ends through a process called mRNA alternative polyadenylation （APA）. Recent studies have demonstrated that APA is dynamically regula...The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3＇ ends through a process called mRNA alternative polyadenylation （APA）. Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation.展开更多
基金Project supported by the National Institutes of Health (NIH) (No.R01 GM090056),USA
文摘The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3＇ ends through a process called mRNA alternative polyadenylation （APA）. Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation.
