Background: Adult T- cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T- cell leukaemia virus type I (HTLV- I). ATLL frequently involves the skin. Objectives: To correlate the clinicopatholog...Background: Adult T- cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T- cell leukaemia virus type I (HTLV- I). ATLL frequently involves the skin. Objectives: To correlate the clinicopathological features and prognosis in patients with ATLL and cutaneous lesions. Methods: We examined the HTLV- I proviral state and the clinicopathological features of the cutaneous lesions in 80 patients with serum anti- ATL antibody, to clarify the correlation between macroscopic/histopathological findings and prognosis. Southern blot analysis was performed in all cases to detect monoclonal HTLV- I proviral DNA integration. Results: The cutaneous lesions of 46 patients were positive for proviral DNA integration. The median survival time of patients with monoclonal proviral DNA integration in cutaneous lesions was 14 months, which was markedly shorter than that of patients negative for proviral DNA integration (72 months). Of the 46 patients with proviral DNA, 21 had solitary or multiple red nodules (including three with subcutaneous induration), eight had multiple red papules and 17 had erythema. Patients with papules and nodules had poorer prognosis than those with erythema. Histopathologically, the prognosis was poorer in patients with nodular or diffuse infiltration of medium- sized to large lymphoma cells, compared with those with perivascular infiltration of small to medium- sized lymphoma cells. Conclusions: Our results show a close correlation between clinicopathological features of HTLV- I- associated cutaneous lesions and prognosis.展开更多
1989年6月25～28日在美国纽约康乃尔大学召开了第二届国际动物遗传工程会议(Second International Symposium onthe Genetic Engineering of Animals)。会议的主要目的是交流近年来动物遗传工程前沿科学研究中的新进展。参加本居会议的...1989年6月25～28日在美国纽约康乃尔大学召开了第二届国际动物遗传工程会议(Second International Symposium onthe Genetic Engineering of Animals)。会议的主要目的是交流近年来动物遗传工程前沿科学研究中的新进展。参加本居会议的有十几个国家的近300名代表,共有80篇论文和综述报告在会议上交流,其中25篇是大会发言,35篇是以墙报形式展出。展开更多
文摘Background: Adult T- cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T- cell leukaemia virus type I (HTLV- I). ATLL frequently involves the skin. Objectives: To correlate the clinicopathological features and prognosis in patients with ATLL and cutaneous lesions. Methods: We examined the HTLV- I proviral state and the clinicopathological features of the cutaneous lesions in 80 patients with serum anti- ATL antibody, to clarify the correlation between macroscopic/histopathological findings and prognosis. Southern blot analysis was performed in all cases to detect monoclonal HTLV- I proviral DNA integration. Results: The cutaneous lesions of 46 patients were positive for proviral DNA integration. The median survival time of patients with monoclonal proviral DNA integration in cutaneous lesions was 14 months, which was markedly shorter than that of patients negative for proviral DNA integration (72 months). Of the 46 patients with proviral DNA, 21 had solitary or multiple red nodules (including three with subcutaneous induration), eight had multiple red papules and 17 had erythema. Patients with papules and nodules had poorer prognosis than those with erythema. Histopathologically, the prognosis was poorer in patients with nodular or diffuse infiltration of medium- sized to large lymphoma cells, compared with those with perivascular infiltration of small to medium- sized lymphoma cells. Conclusions: Our results show a close correlation between clinicopathological features of HTLV- I- associated cutaneous lesions and prognosis.
文摘1989年6月25～28日在美国纽约康乃尔大学召开了第二届国际动物遗传工程会议(Second International Symposium onthe Genetic Engineering of Animals)。会议的主要目的是交流近年来动物遗传工程前沿科学研究中的新进展。参加本居会议的有十几个国家的近300名代表,共有80篇论文和综述报告在会议上交流,其中25篇是大会发言,35篇是以墙报形式展出。
文摘一个科学家小组上周请求美国主管遗传工程安全事务的监护人允许将一个合成基因导入人体。它的发起人说:给政府检查人员介绍的第一次人体试验是一次“演习”。这程序将不治疗疾病,但是,它将试验把外源基因插入人体的方法。它也将有助于逐渐地缓和将有争论的技术应用到实际的争议。主要的实验发起人——W·French Anderson 和必须审查该提案的国家卫生研究院正尝试期待非议。上周,Anderson 将十公斤左右的文件呈递给 NIH 的重组 DNA
