The present paper covers a new process for the synthesis of 1-（2,6,6-trimethyl-1-cyclohexenyl）-3-methyl-2-buten-4-al with dimethyl sulfide, bromomethane and β-ionone as primary materials in four steps, via the carb...The present paper covers a new process for the synthesis of 1-（2,6,6-trimethyl-1-cyclohexenyl）-3-methyl-2-buten-4-al with dimethyl sulfide, bromomethane and β-ionone as primary materials in four steps, via the carbine reaction of dimethyl sulfide and bromomethane, the cyclization of trimethylsulfonium bromide and β-ionone, the opening of epoxy compound and isomerization of C14-aldehyde. The overall yield is 77%. The structure of the titled product was characterized by GC/MS, IR and 1H NMR. The process has many advantages such as facile low-cost materials, high conversion, short reaction time, mild reaction ondition, and less by-products. Furthermore, the part materials can be recycled, the cost and pollution are reduced, so it is feasible for industry production.展开更多
A new method was developed to diastereoselectively synthesize polysubstituted 1,2‐diamine compounds from the reaction of diazoesters with arylamines and diaryl imines by using the dioxazoline ligand L2‐ligated silve...A new method was developed to diastereoselectively synthesize polysubstituted 1,2‐diamine compounds from the reaction of diazoesters with arylamines and diaryl imines by using the dioxazoline ligand L2‐ligated silver catalyst.The Lewis acidity of the silver catalyst affected the different types of substrate diastereoselectivities;It also led to the formation of amine‐exchange side products.展开更多
文摘The present paper covers a new process for the synthesis of 1-（2,6,6-trimethyl-1-cyclohexenyl）-3-methyl-2-buten-4-al with dimethyl sulfide, bromomethane and β-ionone as primary materials in four steps, via the carbine reaction of dimethyl sulfide and bromomethane, the cyclization of trimethylsulfonium bromide and β-ionone, the opening of epoxy compound and isomerization of C14-aldehyde. The overall yield is 77%. The structure of the titled product was characterized by GC/MS, IR and 1H NMR. The process has many advantages such as facile low-cost materials, high conversion, short reaction time, mild reaction ondition, and less by-products. Furthermore, the part materials can be recycled, the cost and pollution are reduced, so it is feasible for industry production.
基金the National Natural Science Foundation of China(21472237)~~
文摘A new method was developed to diastereoselectively synthesize polysubstituted 1,2‐diamine compounds from the reaction of diazoesters with arylamines and diaryl imines by using the dioxazoline ligand L2‐ligated silver catalyst.The Lewis acidity of the silver catalyst affected the different types of substrate diastereoselectivities;It also led to the formation of amine‐exchange side products.
