Based on the hypothesis that mitochondrial myopathy, encephalopathy,lactic acidosis, and strokelike episodes (MELAS) are caused by impaired vasodilation in an intracerebral artery, the authors evaluated the effe cts o...Based on the hypothesis that mitochondrial myopathy, encephalopathy,lactic acidosis, and strokelike episodes (MELAS) are caused by impaired vasodilation in an intracerebral artery, the authors evaluated the effe cts of administering L-arginine, a nitricoxide precursor. Patients were adminis tered L-arginine intravenously at the acute phase or orally at the interictal p hase. L-Arginine infusions significantly improved all strokelike symptoms, sugg esting that oral administration within 30 minutes of a stroke significantly decr eased frequency and severity of strokelike episodes.展开更多
文摘Based on the hypothesis that mitochondrial myopathy, encephalopathy,lactic acidosis, and strokelike episodes (MELAS) are caused by impaired vasodilation in an intracerebral artery, the authors evaluated the effe cts of administering L-arginine, a nitricoxide precursor. Patients were adminis tered L-arginine intravenously at the acute phase or orally at the interictal p hase. L-Arginine infusions significantly improved all strokelike symptoms, sugg esting that oral administration within 30 minutes of a stroke significantly decr eased frequency and severity of strokelike episodes.
