It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit ha...It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated.From the analyses of electrostatic potential, two binding sites of cations can be determined:The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole.The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.展开更多
文摘It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated.From the analyses of electrostatic potential, two binding sites of cations can be determined:The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole.The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.
