Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for oste...Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe_3O_4 nanoparticles into chitosan/polyethylene glycol(PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field(AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells(MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications.展开更多
据悉,维特根集团将会在bauma CHINA 2018展会上展示众多创新产品和技术,共有约50款展品参展,其中有13款机型首次亮相中国市场。除此之外,对于土方工程、筑养路施工、机场建设、石料加工及材料再生应用等领域,维特根集团将会根据具体情...据悉,维特根集团将会在bauma CHINA 2018展会上展示众多创新产品和技术,共有约50款展品参展,其中有13款机型首次亮相中国市场。除此之外,对于土方工程、筑养路施工、机场建设、石料加工及材料再生应用等领域,维特根集团将会根据具体情况定制解决方案,帮助客户经济地完成项目,并实现施工质量最优。展开更多
基金financial support from the National Natural Science Foundation of China (81671829)the 111 Project (B17026)
文摘Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe_3O_4 nanoparticles into chitosan/polyethylene glycol(PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field(AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells(MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications.
文摘据悉,维特根集团将会在bauma CHINA 2018展会上展示众多创新产品和技术,共有约50款展品参展,其中有13款机型首次亮相中国市场。除此之外,对于土方工程、筑养路施工、机场建设、石料加工及材料再生应用等领域,维特根集团将会根据具体情况定制解决方案,帮助客户经济地完成项目,并实现施工质量最优。
