Objective: The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor- 2 (FGF- 2) differ between women with and without endometriosis and to examine the relationsh...Objective: The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor- 2 (FGF- 2) differ between women with and without endometriosis and to examine the relationship between proliferative activity in the endometriotic lesions and the levels of FGF- 2 in serum and peritoneal fluid. Study design: Biopsy specimens of peritoneal endometriotic lesions (n = 25) were analyzed immunohistochemically regarding proliferative activity in stroma, glands, and blood vessels. The FGF- 2 concentration was measured in peritoneal fluid and serum from 25 women with endometriosis and 14 healthy controls. Results: Patients with endometriosis had higher serum concentrations of FGF- 2 during both the proliferative and secretory menstrual phases than healthy women. Peritoneal fluid levels of FGF- 2 differed significantly between women with high and low proliferative activity in their endometriotic lesions. Conclusion: Women with endometriosis have a higher serum level of FGF- 2 than healthy controls.展开更多
文摘Objective: The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor- 2 (FGF- 2) differ between women with and without endometriosis and to examine the relationship between proliferative activity in the endometriotic lesions and the levels of FGF- 2 in serum and peritoneal fluid. Study design: Biopsy specimens of peritoneal endometriotic lesions (n = 25) were analyzed immunohistochemically regarding proliferative activity in stroma, glands, and blood vessels. The FGF- 2 concentration was measured in peritoneal fluid and serum from 25 women with endometriosis and 14 healthy controls. Results: Patients with endometriosis had higher serum concentrations of FGF- 2 during both the proliferative and secretory menstrual phases than healthy women. Peritoneal fluid levels of FGF- 2 differed significantly between women with high and low proliferative activity in their endometriotic lesions. Conclusion: Women with endometriosis have a higher serum level of FGF- 2 than healthy controls.
