为了了解广西桂北地区乙型肝炎病毒(Hepatitis B Virus,HBV)感染者基因型分布情况及探讨HBV感染不同免疫状态与基因型的关系。将HBV感染者按免疫耐受、免疫清除(应答)和免疫不全(病毒残留)三种免疫状态分类,各选150例,共450例,运用实时...为了了解广西桂北地区乙型肝炎病毒(Hepatitis B Virus,HBV)感染者基因型分布情况及探讨HBV感染不同免疫状态与基因型的关系。将HBV感染者按免疫耐受、免疫清除(应答)和免疫不全(病毒残留)三种免疫状态分类,各选150例,共450例,运用实时荧光定量PCR法检测HBV感染三种不同免疫状态者的HBV基因型。450例中B型为323例、C型为94例、B+C混合型为23例和非B非C型为10例;HBV感染三种免疫状态均B型占多数,分别为70.0%、78.0%和67.33%,不同免疫状态基因型构成比差异无统计学意义;免疫状态与基因型相关性无统计学意义;B型HBV-DNA载量高于C型,各组中年龄≥30岁者C型显著多于<30岁者,差异有统计学意义;各基因型间丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)阳性率差别无统计学意义;男女基因型分布差异无统计学意义。结果表明,广西桂北地区HBV基因型以B型为主,C型占部分比例,少量B+C混合型,偶有未能分型;HBV感染免疫耐受、免疫清除(应答)和免疫不全(病毒残留)三种免疫状态均B型占多数,慢性HBV感染免疫状态与HBV基因型相关性无统计学意义。展开更多
Human immunodeficiency virus（HIV）and acquired immunodeficiency syndrome（AIDS）remain major public health problems in China,where approximately 780,000people currently live with HIV,according to the 2012 China AIDS ...Human immunodeficiency virus（HIV）and acquired immunodeficiency syndrome（AIDS）remain major public health problems in China,where approximately 780,000people currently live with HIV,according to the 2012 China AIDS Response Progress Report.Suzhou was an early epidemic region in Jiangsu province and the current situation of HIV-1 prevalence is complicated.展开更多
Human immunodeficiency virus （HIV） emerged as one of the most serious health issues of the modern era. Till date, it challenges the scientists working in the fields related to its prevention, least spread and eradic...Human immunodeficiency virus （HIV） emerged as one of the most serious health issues of the modern era. Till date, it challenges the scientists working in the fields related to its prevention, least spread and eradication. It affects not only the person suffering from it but also the communities and their economies. Mathematical modeling is one of the ways to explore the possibilities of prediction （and control） strategies for contagious deceases. In this paper, we have tried to extend the scope of a currently available prediction model for a continuous time span. For this purpose, an analytical investigation of the system of nonlinear differential equations, governing the HIV infection of CD4 ＋ T-cells, is carried out. A new emerging analytical technique Optimal Variational Iteration Method （OVIM） has been used to obtain an analytical and convergent solution. Analytical solutions are continuous solutions that can be used to predict the phenomena without the involvement of interpolation or extrapolation errors. On the other hand, their use in the derived equations, depending upon solution itself, is far easier than the numerical solutions. We have presented the error analysis and the prediction curves graphically. Moreover, a comparison with traditional Variational Iteration is also provided. It is concluded that the traditional method fails to converge for the updated models which involve the delayed differential equations.展开更多
In this paper, we have studied about the sensitivity analysis of the human immunodeficiency virus （HIV） protease inhibitor （PI） model and estimated the length of the delay. We have fabricated an HIV PI model accom...In this paper, we have studied about the sensitivity analysis of the human immunodeficiency virus （HIV） protease inhibitor （PI） model and estimated the length of the delay. We have fabricated an HIV PI model accompanied with humoral immunity. Stability analysis of the constructed model about its steady states has been deliberated. We have evaluated some numerical simulations for PI model with humoral immunity by using the existing patient data.展开更多
Occult hepatitis B virus(HBV) infection(OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface antigen.The prevalence of OBI is quite variable depending on ...Occult hepatitis B virus(HBV) infection(OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface antigen.The prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world,the different assays utilized in the studies,and the different populations studied.Many studies have been carried out on OBI prevalence in different areas of the world and categories of individuals.The studies show that OBI prevalence seems to be higher among subjects at high risk for HBV infection and with liver disease than among individuals at low risk of infection and without liver disease.展开更多
Occult hepatitis B virus(HBV) infection(OBI) is defined as the presence of HBV DNA in the liver(with or without detectable HBV DNA in serum) for individuals testing HBV surface antigen negative.Until recently,the clin...Occult hepatitis B virus(HBV) infection(OBI) is defined as the presence of HBV DNA in the liver(with or without detectable HBV DNA in serum) for individuals testing HBV surface antigen negative.Until recently,the clinical effect of OBI was unclear on the progression of liver disease;on the development of hepatocellular carcinoma;and on the risk for reactivation or transmission of HBV infection.Several studies suggest a high prevalence of OBI among patients with cryptogenic chronic liver disease,but its role in the progression to cirrhosis remains unclear.Although OBI has been well documented in human immunodeficiency virus(HIV) -positive patients,especially among those coinfected with hepatitis C virus,further studies are needed to determine its current clinical impact in HIV setting.展开更多
文摘为了了解广西桂北地区乙型肝炎病毒(Hepatitis B Virus,HBV)感染者基因型分布情况及探讨HBV感染不同免疫状态与基因型的关系。将HBV感染者按免疫耐受、免疫清除(应答)和免疫不全(病毒残留)三种免疫状态分类,各选150例,共450例,运用实时荧光定量PCR法检测HBV感染三种不同免疫状态者的HBV基因型。450例中B型为323例、C型为94例、B+C混合型为23例和非B非C型为10例;HBV感染三种免疫状态均B型占多数,分别为70.0%、78.0%和67.33%,不同免疫状态基因型构成比差异无统计学意义;免疫状态与基因型相关性无统计学意义;B型HBV-DNA载量高于C型,各组中年龄≥30岁者C型显著多于<30岁者,差异有统计学意义;各基因型间丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)阳性率差别无统计学意义;男女基因型分布差异无统计学意义。结果表明,广西桂北地区HBV基因型以B型为主,C型占部分比例,少量B+C混合型,偶有未能分型;HBV感染免疫耐受、免疫清除(应答)和免疫不全(病毒残留)三种免疫状态均B型占多数,慢性HBV感染免疫状态与HBV基因型相关性无统计学意义。
基金supported by grants from the Open Research Fund Program of the State Key Laboratory of Virology of China (2017IOV003)the Health Department of Jiangsu Province (Y2013062)+2 种基金Suzhou Science Technology Bureau (SYS201452)in part by grants from the National Science Foundation of China (NSFC) (81101257)the Natural Science Foundation of Heilongjiang Province (H201355)
文摘Human immunodeficiency virus（HIV）and acquired immunodeficiency syndrome（AIDS）remain major public health problems in China,where approximately 780,000people currently live with HIV,according to the 2012 China AIDS Response Progress Report.Suzhou was an early epidemic region in Jiangsu province and the current situation of HIV-1 prevalence is complicated.
文摘Human immunodeficiency virus （HIV） emerged as one of the most serious health issues of the modern era. Till date, it challenges the scientists working in the fields related to its prevention, least spread and eradication. It affects not only the person suffering from it but also the communities and their economies. Mathematical modeling is one of the ways to explore the possibilities of prediction （and control） strategies for contagious deceases. In this paper, we have tried to extend the scope of a currently available prediction model for a continuous time span. For this purpose, an analytical investigation of the system of nonlinear differential equations, governing the HIV infection of CD4 ＋ T-cells, is carried out. A new emerging analytical technique Optimal Variational Iteration Method （OVIM） has been used to obtain an analytical and convergent solution. Analytical solutions are continuous solutions that can be used to predict the phenomena without the involvement of interpolation or extrapolation errors. On the other hand, their use in the derived equations, depending upon solution itself, is far easier than the numerical solutions. We have presented the error analysis and the prediction curves graphically. Moreover, a comparison with traditional Variational Iteration is also provided. It is concluded that the traditional method fails to converge for the updated models which involve the delayed differential equations.
文摘In this paper, we have studied about the sensitivity analysis of the human immunodeficiency virus （HIV） protease inhibitor （PI） model and estimated the length of the delay. We have fabricated an HIV PI model accompanied with humoral immunity. Stability analysis of the constructed model about its steady states has been deliberated. We have evaluated some numerical simulations for PI model with humoral immunity by using the existing patient data.
文摘Occult hepatitis B virus(HBV) infection(OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface antigen.The prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world,the different assays utilized in the studies,and the different populations studied.Many studies have been carried out on OBI prevalence in different areas of the world and categories of individuals.The studies show that OBI prevalence seems to be higher among subjects at high risk for HBV infection and with liver disease than among individuals at low risk of infection and without liver disease.
基金Supported by CIBERehd is funded by the Instituto de Salud Carlos Ⅲ
文摘Occult hepatitis B virus(HBV) infection(OBI) is defined as the presence of HBV DNA in the liver(with or without detectable HBV DNA in serum) for individuals testing HBV surface antigen negative.Until recently,the clinical effect of OBI was unclear on the progression of liver disease;on the development of hepatocellular carcinoma;and on the risk for reactivation or transmission of HBV infection.Several studies suggest a high prevalence of OBI among patients with cryptogenic chronic liver disease,but its role in the progression to cirrhosis remains unclear.Although OBI has been well documented in human immunodeficiency virus(HIV) -positive patients,especially among those coinfected with hepatitis C virus,further studies are needed to determine its current clinical impact in HIV setting.
