Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultr...Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultrasound imaging.The morphology of CaCO_3-MB NRs can be controlled by modulating the concentration of Na_2CO_3 aqueous solution.The generation of effective reactive oxygen species(ROS)were confirmed by 1,3-diphenylisobenzofuran(DPBF)probe.Both photodynamic therapy performance and echogenic performance of CaCO_3-MB NRs were investigated to confirm the feasibility of CaCO_3-MB nanohybrids for ultrasound image-guided photodynamic therapy.展开更多
近年来光力学反馈冷却技术对于提升光力学的测量精度以及实现宏观量子叠加均发挥了重要的推动作用.但是传统测量反馈冷却技术受限于测量噪声.最近的研究结合并同时优化了矢量探测反馈冷却与参量压缩技术,不仅突破了传统反馈冷却技术的极...近年来光力学反馈冷却技术对于提升光力学的测量精度以及实现宏观量子叠加均发挥了重要的推动作用.但是传统测量反馈冷却技术受限于测量噪声.最近的研究结合并同时优化了矢量探测反馈冷却与参量压缩技术,不仅突破了传统反馈冷却技术的极限,也突破了参量压缩的3 d B极限,实现了超过30 d B的热噪声抑制.展开更多
Purpose: To evaluate short-term effects of single photodynamic therapy (PDT) for age-related macular degeneration (AMD) accompanied with choroidal neovascularization (CNV).Methods: We analyzed retrospectively the effe...Purpose: To evaluate short-term effects of single photodynamic therapy (PDT) for age-related macular degeneration (AMD) accompanied with choroidal neovascularization (CNV).Methods: We analyzed retrospectively the effects of single PDT for 20 patients (20 eyes) with CNV caused by AMD. Corrected visual acuity, fluorescein angiography (FA) and optic coherence tomography (OCT) were examined before and after PDT. All patients were followed up at least 3 months. Results: At the end of 3-month follow-up, 5 eyes had vision progress, 15 eyes had vision stable and no eye had vision deterioration. Fluorescein angiography one week post PDT showed cessation of fluorescein leakage in 8 eyes with predominant classic CNV, and reduction of fluorescein leakage in 12 eyes with minimal classic CNV or occult CNV without classic component. At the 3-month following PDT fluorescein angiography showed fluorescein leakage reappeared in 4 of 8 eyes with predominant classic CNV. Among 12 eyes with minimal classic CNV or occult CNV without classic component, 9 eyes showed decreased or unchanged fluorescein leakage, 3 eyes had a progression of fluorescein leakage. Optic coherence tomography showed obvious recovery of serous sensory retinal detachment after PDT. Conclusion: PDT may occlude or inhibit CNV caused by AMD in short term. No obvious side effects were noticed.展开更多
Phototherapeutics provides opportunities for cancer therapy because of its high spatiotemporal controllability and minimal invasiveness. For example, photodynamic therapeutics,often termed as photosensitizer (PS), can...Phototherapeutics provides opportunities for cancer therapy because of its high spatiotemporal controllability and minimal invasiveness. For example, photodynamic therapeutics,often termed as photosensitizer (PS), can be administered to the patients with subsequent exposure to a specific light that leads to the death of the disease cells via oxidative damage.However, the efficacy of traditional PS has been limited by several issues including poor tumor specificity, fast renal clearance, and phototoxic side effect on normal tissues [1].展开更多
基金supported by the National Key Research and Development Program of China (2017YFA0106100, 2016YFA0201501)National Natural Science Foundation of China (51325304, 51373017, 51473014, 51521062, 51773013)+1 种基金the Fundamental Research Funds for the Central Universities (BHYC1705A)Higher Education and High-quality and World-class Universities (PY201603)
文摘Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultrasound imaging.The morphology of CaCO_3-MB NRs can be controlled by modulating the concentration of Na_2CO_3 aqueous solution.The generation of effective reactive oxygen species(ROS)were confirmed by 1,3-diphenylisobenzofuran(DPBF)probe.Both photodynamic therapy performance and echogenic performance of CaCO_3-MB NRs were investigated to confirm the feasibility of CaCO_3-MB nanohybrids for ultrasound image-guided photodynamic therapy.
文摘Purpose: To evaluate short-term effects of single photodynamic therapy (PDT) for age-related macular degeneration (AMD) accompanied with choroidal neovascularization (CNV).Methods: We analyzed retrospectively the effects of single PDT for 20 patients (20 eyes) with CNV caused by AMD. Corrected visual acuity, fluorescein angiography (FA) and optic coherence tomography (OCT) were examined before and after PDT. All patients were followed up at least 3 months. Results: At the end of 3-month follow-up, 5 eyes had vision progress, 15 eyes had vision stable and no eye had vision deterioration. Fluorescein angiography one week post PDT showed cessation of fluorescein leakage in 8 eyes with predominant classic CNV, and reduction of fluorescein leakage in 12 eyes with minimal classic CNV or occult CNV without classic component. At the 3-month following PDT fluorescein angiography showed fluorescein leakage reappeared in 4 of 8 eyes with predominant classic CNV. Among 12 eyes with minimal classic CNV or occult CNV without classic component, 9 eyes showed decreased or unchanged fluorescein leakage, 3 eyes had a progression of fluorescein leakage. Optic coherence tomography showed obvious recovery of serous sensory retinal detachment after PDT. Conclusion: PDT may occlude or inhibit CNV caused by AMD in short term. No obvious side effects were noticed.
文摘Phototherapeutics provides opportunities for cancer therapy because of its high spatiotemporal controllability and minimal invasiveness. For example, photodynamic therapeutics,often termed as photosensitizer (PS), can be administered to the patients with subsequent exposure to a specific light that leads to the death of the disease cells via oxidative damage.However, the efficacy of traditional PS has been limited by several issues including poor tumor specificity, fast renal clearance, and phototoxic side effect on normal tissues [1].
