目的:探讨甲巯咪唑联合普萘洛尔治疗对轻中度甲状腺功能亢进症(甲亢)患者甲状腺功能、血清皮质醇(cortisol, COR)、促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)水平的影响。方法:选择我院2017年1月-2018年1月诊治的88例轻中...目的:探讨甲巯咪唑联合普萘洛尔治疗对轻中度甲状腺功能亢进症(甲亢)患者甲状腺功能、血清皮质醇(cortisol, COR)、促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)水平的影响。方法:选择我院2017年1月-2018年1月诊治的88例轻中度甲亢,按照随机数字表法分为观察组与对照组,每组各44例。对照组予甲巯咪唑治疗,观察组予甲巯咪唑联合普萘洛尔治疗,均治疗3个月。比较临床疗效,检测治疗前后血清促甲状腺激素(thyroid stimulating hormone, TSH)、游离三碘甲状腺素(free triiodothyronine, FT 3)、游离甲状腺素(free thyroxine, FT 4)、COR、ACTH水平变化,观察治疗前后心率变化,记录不良反应发生情况。结果:观察组、对照组治疗总有效率分别为95.45%(42/44)、81.82%(36/44),比较差异有统计学意义(χ^ 2=4.061, P =0.044)。与对照组比较,观察组治疗后TSH、COR水平升高,FT 3、FT 4、ACTH水平与心率降低,差异有统计学意义( P <0.001);与本组治疗前比较,两组治疗后TSH、COR水平明显升高,FT 3、FT 4、ACTH水平与心率显著降低,差异有统计学意义( P <0.001)。两组不良反应发生率比较差异无统计学意义( P =1.000)。结论:甲巯咪唑联合普萘洛尔治疗轻中度甲亢疗效较好,不良反应少,可明显改善甲状腺功能,提高血清COR水平,降低ACTH水平。展开更多
AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into norm...AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum （CR）. An abdominal withdrawal reflex （AWR） scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells （MC）, changes of substance P （SP） and substance P receptor （SPR） in colon and change of corticotropin-releasing hormone （CRH） in hypothalamus. RESULTS： The threshold of visceral sense was significantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was significantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION： EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS.展开更多
目的探究普萘洛尔联合甲巯咪唑对甲状腺功能亢进症(甲亢)患者钙磷代谢、糖脂代谢、血清胱抑素C(CysC)、血清皮质醇(COR)、促肾上腺皮质激素(ACTH)水平的影响。方法前瞻性选取2020年6月至2020年9月湖北医药学院附属随州医院收治的甲亢患...目的探究普萘洛尔联合甲巯咪唑对甲状腺功能亢进症(甲亢)患者钙磷代谢、糖脂代谢、血清胱抑素C(CysC)、血清皮质醇(COR)、促肾上腺皮质激素(ACTH)水平的影响。方法前瞻性选取2020年6月至2020年9月湖北医药学院附属随州医院收治的甲亢患者92例为研究对象,采用随机数字表法分为研究组(46例)和对照组(46例)。其中对照组患者均给予甲巯咪唑治疗,研究组在对照组基础上联合普萘洛尔治疗,2组治疗时间均为3个月。观察2组患者治疗1、2、3个月后的临床疗效;比较2组患者治疗后血钙、血磷、糖脂代谢[低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、餐后2 h血糖(2 h PG)、空腹血糖(FBG)]、CysC、COR、ACTH水平的差异。结果研究组治疗1、2、3个月后总有效率显著高于对照组,组间比较差异有统计学意义(P<0.05)。重复测量方差结果显示,治疗1、2、3个月后,研究组患者的血清钙、COR水平均高于对照组,血清磷、CysC、ACTH水平均低于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,研究组患者的LDL-C、TC、TC水平低于对照组,差异均有统计学意义(P<0.05),而LDL-C、TC、TC水平比较差异无统计学意义(P>0.05)。结论普萘洛尔联合甲巯咪唑治疗可有效改善甲亢患者甲状腺功能,提高患者血清Ca、COR水平,降低血清P、CysC、ACTH水平,且对患者糖脂代谢影响较小。展开更多
文摘目的:探讨甲巯咪唑联合普萘洛尔治疗对轻中度甲状腺功能亢进症(甲亢)患者甲状腺功能、血清皮质醇(cortisol, COR)、促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)水平的影响。方法:选择我院2017年1月-2018年1月诊治的88例轻中度甲亢,按照随机数字表法分为观察组与对照组,每组各44例。对照组予甲巯咪唑治疗,观察组予甲巯咪唑联合普萘洛尔治疗,均治疗3个月。比较临床疗效,检测治疗前后血清促甲状腺激素(thyroid stimulating hormone, TSH)、游离三碘甲状腺素(free triiodothyronine, FT 3)、游离甲状腺素(free thyroxine, FT 4)、COR、ACTH水平变化,观察治疗前后心率变化,记录不良反应发生情况。结果:观察组、对照组治疗总有效率分别为95.45%(42/44)、81.82%(36/44),比较差异有统计学意义(χ^ 2=4.061, P =0.044)。与对照组比较,观察组治疗后TSH、COR水平升高,FT 3、FT 4、ACTH水平与心率降低,差异有统计学意义( P <0.001);与本组治疗前比较,两组治疗后TSH、COR水平明显升高,FT 3、FT 4、ACTH水平与心率显著降低,差异有统计学意义( P <0.001)。两组不良反应发生率比较差异无统计学意义( P =1.000)。结论:甲巯咪唑联合普萘洛尔治疗轻中度甲亢疗效较好,不良反应少,可明显改善甲状腺功能,提高血清COR水平,降低ACTH水平。
基金Supported by Open Fund of Key Laboratory of Acupuncture Combined with Medication (Nanjing University of TCM), Ministry of Education, No. KJA200809Shanghai Rising-Star Program, No. 08QA14064Shanghai Leading Academic Discipline Project, No. S30304
文摘AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum （CR）. An abdominal withdrawal reflex （AWR） scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells （MC）, changes of substance P （SP） and substance P receptor （SPR） in colon and change of corticotropin-releasing hormone （CRH） in hypothalamus. RESULTS： The threshold of visceral sense was significantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was significantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION： EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS.
文摘目的探究普萘洛尔联合甲巯咪唑对甲状腺功能亢进症(甲亢)患者钙磷代谢、糖脂代谢、血清胱抑素C(CysC)、血清皮质醇(COR)、促肾上腺皮质激素(ACTH)水平的影响。方法前瞻性选取2020年6月至2020年9月湖北医药学院附属随州医院收治的甲亢患者92例为研究对象,采用随机数字表法分为研究组(46例)和对照组(46例)。其中对照组患者均给予甲巯咪唑治疗,研究组在对照组基础上联合普萘洛尔治疗,2组治疗时间均为3个月。观察2组患者治疗1、2、3个月后的临床疗效;比较2组患者治疗后血钙、血磷、糖脂代谢[低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、餐后2 h血糖(2 h PG)、空腹血糖(FBG)]、CysC、COR、ACTH水平的差异。结果研究组治疗1、2、3个月后总有效率显著高于对照组,组间比较差异有统计学意义(P<0.05)。重复测量方差结果显示,治疗1、2、3个月后,研究组患者的血清钙、COR水平均高于对照组,血清磷、CysC、ACTH水平均低于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,研究组患者的LDL-C、TC、TC水平低于对照组,差异均有统计学意义(P<0.05),而LDL-C、TC、TC水平比较差异无统计学意义(P>0.05)。结论普萘洛尔联合甲巯咪唑治疗可有效改善甲亢患者甲状腺功能,提高患者血清Ca、COR水平,降低血清P、CysC、ACTH水平,且对患者糖脂代谢影响较小。
