Objectives To explore serum cytokines levels (including IL-1β, sIL-2R, IL-6, TNF-α, and IFN-ν) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to es...Objectives To explore serum cytokines levels (including IL-1β, sIL-2R, IL-6, TNF-α, and IFN-ν) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS. Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1β, sIL-2R, IL-6, TNF-α, and IFN-νwere measured by enzyme linked immunosorbent assay. ResultsSerum IL-1β, sIL-2R, IL-6, TNF-αwere significantly higher in AMI group or UAP group compared to the con-trol group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-νshows no signifi-cant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner’s QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤6 scores group and > 6 scores group. Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a us-eful marker reflecting disease stability.展开更多
文摘Objectives To explore serum cytokines levels (including IL-1β, sIL-2R, IL-6, TNF-α, and IFN-ν) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS. Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1β, sIL-2R, IL-6, TNF-α, and IFN-νwere measured by enzyme linked immunosorbent assay. ResultsSerum IL-1β, sIL-2R, IL-6, TNF-αwere significantly higher in AMI group or UAP group compared to the con-trol group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-νshows no signifi-cant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner’s QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤6 scores group and > 6 scores group. Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a us-eful marker reflecting disease stability.
