A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imagi...A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen.展开更多
文摘A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen.
文摘目的：通过对上海徐汇区中年妇女围绝经期症状的调查，探讨上海中年妇女围绝经期症状发生情况及其影响因素。方法采用改良Kupperman评分量表（ KMI）及一般情况调查表对2012年8月1日至2013年12月31日在上海交通大学附属第六人民医院体检中心进行正常体检的年龄在40～60岁的中年妇女进行问卷调查，并分析调查结果。结果本次研究中，共纳入符合标准的妇女2046例。受试者平均年龄51．23±7．00岁。中年妇女围绝经期综合征的发生率为66．9％（ KMI总分＞6分）。随着被调查者年龄的增加，绝经状态的递进，围绝经期综合征的发生率增高。最常见的围绝经期症状依次为疲乏（83．38％）、性生活困难（55．67％）、骨关节痛（50．29％）、失眠（48．29％）和情绪波动（40．71％）。回归分析显示年龄增加、受教育程度越低、经济收入越低、初潮年龄越晚、流产次数越多、合并冠心病是围绝经期症状加重的危险因素（ t 值分别为22．533、－4．055、－2．088、2．709、5．522、4．203，均P＜0．05）。结论上海徐汇地区中年妇女围绝经期症状的发生率较高，卫生医疗机构应针对上海中年妇女围绝经期特点提供更多的保健措施。
