Purpose: To investigate whether vascular endothelial growth factor (VEGF) or soluble intercellular adhesion molecule 1 (sICAM-1) is related to diabetic macular edema (DME). Design: Retrospective case-control study. Pa...Purpose: To investigate whether vascular endothelial growth factor (VEGF) or soluble intercellular adhesion molecule 1 (sICAM-1) is related to diabetic macular edema (DME). Design: Retrospective case-control study. Participants: Thirty-three patients who had DME and 13 patients with nondiabetic ocular disease (control group). Methods: Vitreous fluid samples were obtained at the time of vitreoretinal surgery, and the VEGF and sICAM-1 levels in vitreous fluid and plasma were measured by enzyme-linked immunosorbent assay. Main Outcome Measures: Relationship between vitreous levels of VEGF or sICAM-1 and DME. Results: Vitreous levels of VEGF and sICAM-1 were significantly higher in DME patients than in control patients (P < 0.0001 and P=0.0004, respectively). The vitreous level of VEGF was significantly correlated with that of sICAM-1 (P < 0.0001). Vitreous levels of both VEGF and sICAM-1 were significantly higher in patients with hyperfluorescent DME than in those with minimally fluorescent DME (P=0.0027 and P=0.0005, respectively). The vitreous levels of bothVEGF and sICAM-1 were significantly correlated with retinal thickness at the central fovea (P < 0.0001 and P= 0.0005, respectively) Conclusions: We found that both VEGF and sICAM-1 were elevated in the vitreous fluid of patients with hyperfluorescent DME. These results suggest that VEGF and ICAM-1 are related to the increase of vascular permeability in DME patients.展开更多
目的应用相干光断层扫描血管成像技术(OCTA)观察非增生期糖尿病视网膜病变(NPDR)患者黄斑区微血管形态学变化。方法采用回顾性描述性研究设计。采集2016年2月至2016年6月在天津市眼科医院经眼底荧光血管造影确诊的NPDR患者90例90只眼(DR...目的应用相干光断层扫描血管成像技术(OCTA)观察非增生期糖尿病视网膜病变(NPDR)患者黄斑区微血管形态学变化。方法采用回顾性描述性研究设计。采集2016年2月至2016年6月在天津市眼科医院经眼底荧光血管造影确诊的NPDR患者90例90只眼(DR组)及正常人30例30只眼(正常对照组)纳入研究。利用OCTA测量并记录DR组和正常对照组黄斑中心凹无血管区(FAZ)面积及黄斑区血管密度。结果与正常对照组相比,DR组FAZ面积明显扩大[(0.454±0.038)mm^2 vs (0.353±0.058)mm^2],黄斑区血管密度明显减小[(36.6±4.58)%vs (52.8±3.39)%],差异有统计学意义(P<0.05)。Spearman秩相关检验结果显示,黄斑区血管密度与NPDR病变严重程度呈负相关(r=-0.390,P<0.05),但不同分期NPDR间FAZ面积相比较差异无统计学意义(P>0.05)。结论黄斑区平均血管密度比FAZ面积的大小在判断NPDR病情严重程度上更有特异性。OCTA是一种快速、无创的可早期评价NPDR患者黄斑区微循环异常的有效手段。展开更多
文摘Purpose: To investigate whether vascular endothelial growth factor (VEGF) or soluble intercellular adhesion molecule 1 (sICAM-1) is related to diabetic macular edema (DME). Design: Retrospective case-control study. Participants: Thirty-three patients who had DME and 13 patients with nondiabetic ocular disease (control group). Methods: Vitreous fluid samples were obtained at the time of vitreoretinal surgery, and the VEGF and sICAM-1 levels in vitreous fluid and plasma were measured by enzyme-linked immunosorbent assay. Main Outcome Measures: Relationship between vitreous levels of VEGF or sICAM-1 and DME. Results: Vitreous levels of VEGF and sICAM-1 were significantly higher in DME patients than in control patients (P < 0.0001 and P=0.0004, respectively). The vitreous level of VEGF was significantly correlated with that of sICAM-1 (P < 0.0001). Vitreous levels of both VEGF and sICAM-1 were significantly higher in patients with hyperfluorescent DME than in those with minimally fluorescent DME (P=0.0027 and P=0.0005, respectively). The vitreous levels of bothVEGF and sICAM-1 were significantly correlated with retinal thickness at the central fovea (P < 0.0001 and P= 0.0005, respectively) Conclusions: We found that both VEGF and sICAM-1 were elevated in the vitreous fluid of patients with hyperfluorescent DME. These results suggest that VEGF and ICAM-1 are related to the increase of vascular permeability in DME patients.
文摘目的应用相干光断层扫描血管成像技术(OCTA)观察非增生期糖尿病视网膜病变(NPDR)患者黄斑区微血管形态学变化。方法采用回顾性描述性研究设计。采集2016年2月至2016年6月在天津市眼科医院经眼底荧光血管造影确诊的NPDR患者90例90只眼(DR组)及正常人30例30只眼(正常对照组)纳入研究。利用OCTA测量并记录DR组和正常对照组黄斑中心凹无血管区(FAZ)面积及黄斑区血管密度。结果与正常对照组相比,DR组FAZ面积明显扩大[(0.454±0.038)mm^2 vs (0.353±0.058)mm^2],黄斑区血管密度明显减小[(36.6±4.58)%vs (52.8±3.39)%],差异有统计学意义(P<0.05)。Spearman秩相关检验结果显示,黄斑区血管密度与NPDR病变严重程度呈负相关(r=-0.390,P<0.05),但不同分期NPDR间FAZ面积相比较差异无统计学意义(P>0.05)。结论黄斑区平均血管密度比FAZ面积的大小在判断NPDR病情严重程度上更有特异性。OCTA是一种快速、无创的可早期评价NPDR患者黄斑区微循环异常的有效手段。
