The sponge-associated fungus Nectria sp.HLS206,which belongs to the order of Hypocreales,was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea.The secondary metabolites of the fungus...The sponge-associated fungus Nectria sp.HLS206,which belongs to the order of Hypocreales,was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea.The secondary metabolites of the fungus were isolated.From the solid cultures,five compounds were purified,which are chalmicrin（1）,hypocrealesate（2）,fucosterol（3）,stigmasterol（4） and β-sitosterol（5）.The structures of the 5 compounds were elucidated by ESI-MS,1D and 2D NMR spectra（COSY,HMQC and HMBC）.To the best of our knowledge,it is the first time compound 1 was isolated from the order of Hypocreales,and the spectral data of compound 2 are also firstly reported.展开更多
基金funded by the United States National Science Foundation (NSF) PEET grant DEB-0731510 ‘Monographic Studies in the Nectriaceae,Hypocreales:Nectria,Cosmospora,and Neonectria’ to P. Chaverri,A.Y. Rossman,and G.J. Samuels
基金National Science and Technology Project of China(Grant No.2009ZX09301-003-4-1)
文摘The sponge-associated fungus Nectria sp.HLS206,which belongs to the order of Hypocreales,was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea.The secondary metabolites of the fungus were isolated.From the solid cultures,five compounds were purified,which are chalmicrin（1）,hypocrealesate（2）,fucosterol（3）,stigmasterol（4） and β-sitosterol（5）.The structures of the 5 compounds were elucidated by ESI-MS,1D and 2D NMR spectra（COSY,HMQC and HMBC）.To the best of our knowledge,it is the first time compound 1 was isolated from the order of Hypocreales,and the spectral data of compound 2 are also firstly reported.
