AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the stu...AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus,hypertention,hepatolithiasis,primary sclerosing cholangitis,liver fluke infection (Clonorchis sinensis ),was investigated through clinical records. Blood from all participants was tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. Odds ratios (OR) and 95% confi dence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with controls,ICC patients had a higher prevalence of HBsAg seropositivity (48.4% vs 9.6%,P < 0.000),and hepatolithiasis (5.4% vs 1.1%,P = 0.001). By multivariate analysis,the signif icant risk factors for development of ICC were HBsAg seropositivity (adjusted OR,8.876,95% CI,5.973-13.192),and hepatolithiasis (adjusted OR,5.765,95% CI,1.972-16.851). The prevalence of anti-HCV seropositivity,diabetes mellitus,hypertention,cigarette smoking,and alcohol consumption were not significantly different between cases and controls. CONCLUSION: These findings suggest that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China.展开更多
2014年,江苏省认真贯彻国家艾滋病性病防治相关工作要求,围绕《江苏省“十二五”艾滋病防治行动计划》和《中国预防与控制梅毒规划(2010-2020年)》确定的工作目标和任务,顺利完成了全年的艾滋病性病防治工作任务,艾滋病疫情呈现以下...2014年,江苏省认真贯彻国家艾滋病性病防治相关工作要求,围绕《江苏省“十二五”艾滋病防治行动计划》和《中国预防与控制梅毒规划(2010-2020年)》确定的工作目标和任务,顺利完成了全年的艾滋病性病防治工作任务,艾滋病疫情呈现以下主要特征:全省艾滋病疫情总体呈低流行态势,男男性接触人群(Men who have sex withmen,MSM)流行程度较高;艾滋病流行范围广,地区差异大;性传播持续成为主要传播途径,同性性传播上升速度明显;各地流行模式多样化,重点人群感染上升明显.展开更多
文摘AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus,hypertention,hepatolithiasis,primary sclerosing cholangitis,liver fluke infection (Clonorchis sinensis ),was investigated through clinical records. Blood from all participants was tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. Odds ratios (OR) and 95% confi dence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with controls,ICC patients had a higher prevalence of HBsAg seropositivity (48.4% vs 9.6%,P < 0.000),and hepatolithiasis (5.4% vs 1.1%,P = 0.001). By multivariate analysis,the signif icant risk factors for development of ICC were HBsAg seropositivity (adjusted OR,8.876,95% CI,5.973-13.192),and hepatolithiasis (adjusted OR,5.765,95% CI,1.972-16.851). The prevalence of anti-HCV seropositivity,diabetes mellitus,hypertention,cigarette smoking,and alcohol consumption were not significantly different between cases and controls. CONCLUSION: These findings suggest that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China.
文摘2014年,江苏省认真贯彻国家艾滋病性病防治相关工作要求,围绕《江苏省“十二五”艾滋病防治行动计划》和《中国预防与控制梅毒规划(2010-2020年)》确定的工作目标和任务,顺利完成了全年的艾滋病性病防治工作任务,艾滋病疫情呈现以下主要特征:全省艾滋病疫情总体呈低流行态势,男男性接触人群(Men who have sex withmen,MSM)流行程度较高;艾滋病流行范围广,地区差异大;性传播持续成为主要传播途径,同性性传播上升速度明显;各地流行模式多样化,重点人群感染上升明显.