AIMTo describe magnetic resonance (MR) imaging features of pancreatic neuroendocrine neoplasms (PanNENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and to determine t...AIMTo describe magnetic resonance (MR) imaging features of pancreatic neuroendocrine neoplasms (PanNENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and to determine the accuracy of MR imaging features in predicting their biological behavior.METHODSThis study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 PanNEN patients (29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTSIll defined margins were more common in G2-3 and stage III-IV PanNENs than in G1 and low-stage tumors (P < 0.001); this feature had high specificity in the identification of G2-3 and stage III-IV tumors (90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage III-IV lesions compared to well differentiated and low-stage tumors (1.09 × 10<sup>-3</sup> mm<sup>2</sup>/s vs 1.45 × 10<sup>-3</sup> mm<sup>2</sup>/s and 1.10 × 10<sup>-3</sup> mm<sup>2</sup>/s vs 1.53 × 10<sup>-3</sup> mm<sup>2</sup>/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cut-offs of 1.21 and 1.28 × 10<sup>-3</sup> mm<sup>2</sup>/s for the identification of G2-3 and stage III-IV tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64% (95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSIONMR features of PanNENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors.展开更多
AIM To evaluate the association between mortality-to-incidence ratios(MIRs) and health disparities.METHODS In this study, we used the GLOBOCAN 2012 database to obtain the cancer incidence and mortality data for 57 cou...AIM To evaluate the association between mortality-to-incidence ratios(MIRs) and health disparities.METHODS In this study, we used the GLOBOCAN 2012 database to obtain the cancer incidence and mortality data for 57 countries, and combined this information with the World Health Organization(WHO) rankings and total expenditures on health/gross domestic product(e/GDP). The associations between variables and MIRs were analyzed by linear regression analyses and the 57 countries were selected according to their data quality. RESULTS The more developed regions showed high gastric cancer incidence and mortality crude rates, but lower MIR values than the less developed regions(0.64 vs 0.80, respectively). Among six continents, Oceania had the lowest(0.60) and Africa had the highest(0.91) MIR. A good WHO ranking and a high e/GDP were significantly associated with low MIRs(P = 0.001 and P = 0.001, respectively).CONCLUSION The MIR variation for gastric cancer would predict regional health disparities.展开更多
The 7th of April is always appointed to be ”World Health Day” by World Health O rganization (WHO), to celebrate the anniversary of its founding in 1946. World Health Day (WHD) 2004 focuses on road traffic injuries a...The 7th of April is always appointed to be ”World Health Day” by World Health O rganization (WHO), to celebrate the anniversary of its founding in 1946. World Health Day (WHD) 2004 focuses on road traffic injuries and measures to pre vent them, and the slogan for the WHD 2004 is ”Road Safety is No Accident”. 1 W HO calls all people to be concerned with road safety on WHD 2004 and beyond. In fact, almost everybody is related with road traffic, and everybody may be consid ered as a road user. Occurrence of road traffic injury (RTI) It is estimated that in 2002 road crashes killed 1.18 million people and inj ured about 20 to 50 million more. Millions were hospitalized for days, weeks or months. Perhaps 5 million were disabled for life. Every day as many as 140 000 people are injured because of road crashes. More than 3 000 die and about 15 000 are disabled for life. It is predicted that by the year 2020, the an nual number of deaths and disabilities from road traffic injuries will increase by 60% or more, and could take third place in the rank order of disease burden ( DALYs) by the year 2000 as compared with the ninth in 1990. 2展开更多
文摘AIMTo describe magnetic resonance (MR) imaging features of pancreatic neuroendocrine neoplasms (PanNENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and to determine the accuracy of MR imaging features in predicting their biological behavior.METHODSThis study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 PanNEN patients (29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTSIll defined margins were more common in G2-3 and stage III-IV PanNENs than in G1 and low-stage tumors (P < 0.001); this feature had high specificity in the identification of G2-3 and stage III-IV tumors (90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage III-IV lesions compared to well differentiated and low-stage tumors (1.09 × 10<sup>-3</sup> mm<sup>2</sup>/s vs 1.45 × 10<sup>-3</sup> mm<sup>2</sup>/s and 1.10 × 10<sup>-3</sup> mm<sup>2</sup>/s vs 1.53 × 10<sup>-3</sup> mm<sup>2</sup>/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cut-offs of 1.21 and 1.28 × 10<sup>-3</sup> mm<sup>2</sup>/s for the identification of G2-3 and stage III-IV tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64% (95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSIONMR features of PanNENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors.
文摘AIM To evaluate the association between mortality-to-incidence ratios(MIRs) and health disparities.METHODS In this study, we used the GLOBOCAN 2012 database to obtain the cancer incidence and mortality data for 57 countries, and combined this information with the World Health Organization(WHO) rankings and total expenditures on health/gross domestic product(e/GDP). The associations between variables and MIRs were analyzed by linear regression analyses and the 57 countries were selected according to their data quality. RESULTS The more developed regions showed high gastric cancer incidence and mortality crude rates, but lower MIR values than the less developed regions(0.64 vs 0.80, respectively). Among six continents, Oceania had the lowest(0.60) and Africa had the highest(0.91) MIR. A good WHO ranking and a high e/GDP were significantly associated with low MIRs(P = 0.001 and P = 0.001, respectively).CONCLUSION The MIR variation for gastric cancer would predict regional health disparities.
文摘The 7th of April is always appointed to be ”World Health Day” by World Health O rganization (WHO), to celebrate the anniversary of its founding in 1946. World Health Day (WHD) 2004 focuses on road traffic injuries and measures to pre vent them, and the slogan for the WHD 2004 is ”Road Safety is No Accident”. 1 W HO calls all people to be concerned with road safety on WHD 2004 and beyond. In fact, almost everybody is related with road traffic, and everybody may be consid ered as a road user. Occurrence of road traffic injury (RTI) It is estimated that in 2002 road crashes killed 1.18 million people and inj ured about 20 to 50 million more. Millions were hospitalized for days, weeks or months. Perhaps 5 million were disabled for life. Every day as many as 140 000 people are injured because of road crashes. More than 3 000 die and about 15 000 are disabled for life. It is predicted that by the year 2020, the an nual number of deaths and disabilities from road traffic injuries will increase by 60% or more, and could take third place in the rank order of disease burden ( DALYs) by the year 2000 as compared with the ninth in 1990. 2
