Chiral sulfonamides derived from(d)-10-camphorsulfonyl chloride and chiral amines were prepared and used in the copper-catalyzed conjugate addition of organometallic reagents to enones.The chiral sulfonamides/CuCN cat...Chiral sulfonamides derived from(d)-10-camphorsulfonyl chloride and chiral amines were prepared and used in the copper-catalyzed conjugate addition of organometallic reagents to enones.The chiral sulfonamides/CuCN catalysts provided high catalytic activity and moderate enantioselectivity in the conjugate addition of diethylzinc to 2-cyclohexenone and 2-cyclohepteneone,but low enantioselectivity to the 2-cyclopentenone and acyclic enones.展开更多
文摘Chiral sulfonamides derived from(d)-10-camphorsulfonyl chloride and chiral amines were prepared and used in the copper-catalyzed conjugate addition of organometallic reagents to enones.The chiral sulfonamides/CuCN catalysts provided high catalytic activity and moderate enantioselectivity in the conjugate addition of diethylzinc to 2-cyclohexenone and 2-cyclohepteneone,but low enantioselectivity to the 2-cyclopentenone and acyclic enones.
