为了清晰了解国内外城市生态修复领域的研究现状和未来发展路径,应用CitespaceⅤ信息可视化分析软件,对Web of Science^（TM）数据库中2000—2017年城市生态修复领域的612篇文献进行了基础知识框架、研究热点、发展趋势的研究,并绘制了...为了清晰了解国内外城市生态修复领域的研究现状和未来发展路径,应用CitespaceⅤ信息可视化分析软件,对Web of Science^（TM）数据库中2000—2017年城市生态修复领域的612篇文献进行了基础知识框架、研究热点、发展趋势的研究,并绘制了网络知识图谱。结果表明：该领域的研究可大致分为4个发展阶段;研究热点主要包括城市生物多样性、城市景观规划与设计、城市生态系统服务等,其中城市生态系统服务突显程度最高,尤其在最近两年该方面研究迅速增多,使其成为主要研究热点。在该领域中美国起步较早且影响力较大,相较而言我国还存在一定差距。今后应在继续增加相关热点问题研究的同时,增加国内与国外相关机构、国内机构间的相互交流与合作。展开更多
Thromboembolism is a significant cause of morbidity and mortality in patients with inflammatory bowel disease （IBD）. Recent data suggest thromboembolism as a disease-specific extraintestinal manifestation of IBD, wh...Thromboembolism is a significant cause of morbidity and mortality in patients with inflammatory bowel disease （IBD）. Recent data suggest thromboembolism as a disease-specific extraintestinal manifestation of IBD, which is developed as the result of multiple interactions between acquired and genetic risk factors. There is evidence indicating an imbalance of procoagulant, anticoagulant and fibrinolitic factors predisposing in thrombosis in patients with IBD. The genetic factors that have been suggested to interfere in the thrombotic manifestations of IBD include factor V Leiden, factor Ⅱ （prothrombin, G20210A）, methylenetetrahydrofolate reductase gene mutation （MTHFR, 6777T, plasminogen activator inhibitor type 1 （PAI-1） gene mutation and factor X Ⅲ （val34leu）. In this article we review the current data and future prospects on the role of genetic risk factors in the development of thromboembolism in TBD.展开更多
To explore the relationship between genetic variation in coagulation factor Ⅴ and the occurrence of coronary arterial disease (CAD) Methods Unrelated 86 patients with CAD and 102 healthy controls were analyzed by ...To explore the relationship between genetic variation in coagulation factor Ⅴ and the occurrence of coronary arterial disease (CAD) Methods Unrelated 86 patients with CAD and 102 healthy controls were analyzed by polymerase chain reaction denaturing gradient gel electrophoresis (PCR DGGE) to detect variations in the entire twenty five exons of the factor Ⅴ gene Results Polymorphisms in exon 4 [642 GT (Ser156)], exon 10 [1628 GA (Arg485Lys)], exon 13 [4070 AG (His1299Arg)] and exon 16 [5380 GA (Val1736Met)] were documented The study also identified a novel polymorphism in exon 2 (327 AG) which did not result in amino acid residue substitution The Leiden mutation (Arg506Gln) was not detected in any of our 188 subjects Among the 5 polymorphisms, the allele frequency of 1628 GA was significantly different between CAD patients and controls (0 69 vs 0 81, χ 2=6 908, P <0 01) This is the first report of this finding in a Chinese population Conclusion 1628 GA polymorphism is associated with CAD and it may be a risk factor for CAD morbidity in the Chinese population展开更多
AIM:To investigate the status of the lymphatic vessels in the small bowel affected by Crohn's disease(CD) at the moment of surgery.METHODS:During the period January 2011-June 2011,25 consecutive patients affected ...AIM:To investigate the status of the lymphatic vessels in the small bowel affected by Crohn's disease(CD) at the moment of surgery.METHODS:During the period January 2011-June 2011,25 consecutive patients affected by CD were operated on in our Institution.During surgery,Patent Blue Ⅴ was injected subserosally and the way it spread along the subserosa of the intestinal wall,through the mesenterial layers towards the main lymphatic collectors and eventually to the lymph nodes was observed and recorded.Since some patients had been undergone strictureplasty at previous surgery,we also examined the status of intestinal lymph vessels after previous strictureplasties.The same procedure was performed in a control group of 5 patients affected by colorectal cancer.Length of lesions,caliber,maximal thickness of the diseased intestinal wall,thickness of the wall at injection site and thickness of the mesentery were evaluated at surgery.RESULTS:We observed three features after the injection of Patent Blue Ⅴ in the intestinal loops:(1) Macroscopically healthy terminal ileum of patients with CD or colon cancer showed thin lymphatic vessels linearly directed toward the mesentery;(2) In mild lesions in which the intestinal wall did not reach 8 mm of thickness,we observed short,wide and tortuous lymphatic vessels directed longitudinally along the intestinal axis toward disease-free areas and then transversally toward the mesentery;and(3) Injection in the severely affected lesions,that had a thickness of the intestinal wall over 10 mm,did not show any feature of lymphatic vessels at least on the subserosal surface.There was a correlation between the thickness of the parietal wall and the severity of the lymphatic alterations.Normal lymphatic vessels were observed at previous strictureplasties in the presence of complete regression of the inflammation.CONCLUSION:Injection of Patent Blue Ⅴ in the intestinal wall could help distinguish healthy tracts of the small bowel from those macroscopically borderline.展开更多
文摘为了清晰了解国内外城市生态修复领域的研究现状和未来发展路径,应用CitespaceⅤ信息可视化分析软件,对Web of Science^（TM）数据库中2000—2017年城市生态修复领域的612篇文献进行了基础知识框架、研究热点、发展趋势的研究,并绘制了网络知识图谱。结果表明：该领域的研究可大致分为4个发展阶段;研究热点主要包括城市生物多样性、城市景观规划与设计、城市生态系统服务等,其中城市生态系统服务突显程度最高,尤其在最近两年该方面研究迅速增多,使其成为主要研究热点。在该领域中美国起步较早且影响力较大,相较而言我国还存在一定差距。今后应在继续增加相关热点问题研究的同时,增加国内与国外相关机构、国内机构间的相互交流与合作。
文摘Thromboembolism is a significant cause of morbidity and mortality in patients with inflammatory bowel disease （IBD）. Recent data suggest thromboembolism as a disease-specific extraintestinal manifestation of IBD, which is developed as the result of multiple interactions between acquired and genetic risk factors. There is evidence indicating an imbalance of procoagulant, anticoagulant and fibrinolitic factors predisposing in thrombosis in patients with IBD. The genetic factors that have been suggested to interfere in the thrombotic manifestations of IBD include factor V Leiden, factor Ⅱ （prothrombin, G20210A）, methylenetetrahydrofolate reductase gene mutation （MTHFR, 6777T, plasminogen activator inhibitor type 1 （PAI-1） gene mutation and factor X Ⅲ （val34leu）. In this article we review the current data and future prospects on the role of genetic risk factors in the development of thromboembolism in TBD.
基金ThisstudywassupportedbytheScientificandTechnologicalCommitteeofShanghai (No 9741 1 90 0 3)
文摘To explore the relationship between genetic variation in coagulation factor Ⅴ and the occurrence of coronary arterial disease (CAD) Methods Unrelated 86 patients with CAD and 102 healthy controls were analyzed by polymerase chain reaction denaturing gradient gel electrophoresis (PCR DGGE) to detect variations in the entire twenty five exons of the factor Ⅴ gene Results Polymorphisms in exon 4 [642 GT (Ser156)], exon 10 [1628 GA (Arg485Lys)], exon 13 [4070 AG (His1299Arg)] and exon 16 [5380 GA (Val1736Met)] were documented The study also identified a novel polymorphism in exon 2 (327 AG) which did not result in amino acid residue substitution The Leiden mutation (Arg506Gln) was not detected in any of our 188 subjects Among the 5 polymorphisms, the allele frequency of 1628 GA was significantly different between CAD patients and controls (0 69 vs 0 81, χ 2=6 908, P <0 01) This is the first report of this finding in a Chinese population Conclusion 1628 GA polymorphism is associated with CAD and it may be a risk factor for CAD morbidity in the Chinese population
文摘AIM:To investigate the status of the lymphatic vessels in the small bowel affected by Crohn's disease(CD) at the moment of surgery.METHODS:During the period January 2011-June 2011,25 consecutive patients affected by CD were operated on in our Institution.During surgery,Patent Blue Ⅴ was injected subserosally and the way it spread along the subserosa of the intestinal wall,through the mesenterial layers towards the main lymphatic collectors and eventually to the lymph nodes was observed and recorded.Since some patients had been undergone strictureplasty at previous surgery,we also examined the status of intestinal lymph vessels after previous strictureplasties.The same procedure was performed in a control group of 5 patients affected by colorectal cancer.Length of lesions,caliber,maximal thickness of the diseased intestinal wall,thickness of the wall at injection site and thickness of the mesentery were evaluated at surgery.RESULTS:We observed three features after the injection of Patent Blue Ⅴ in the intestinal loops:(1) Macroscopically healthy terminal ileum of patients with CD or colon cancer showed thin lymphatic vessels linearly directed toward the mesentery;(2) In mild lesions in which the intestinal wall did not reach 8 mm of thickness,we observed short,wide and tortuous lymphatic vessels directed longitudinally along the intestinal axis toward disease-free areas and then transversally toward the mesentery;and(3) Injection in the severely affected lesions,that had a thickness of the intestinal wall over 10 mm,did not show any feature of lymphatic vessels at least on the subserosal surface.There was a correlation between the thickness of the parietal wall and the severity of the lymphatic alterations.Normal lymphatic vessels were observed at previous strictureplasties in the presence of complete regression of the inflammation.CONCLUSION:Injection of Patent Blue Ⅴ in the intestinal wall could help distinguish healthy tracts of the small bowel from those macroscopically borderline.
