利用知识可视化软件(CiteSpaceⅡ),对Web of Science(SCI,SSCI,A&HCI)中收录的1975—2010年间的988篇知识交流研究论文进行分析,分别对相关文献的时间、地区、机构和期刊分布,主要研究领域以及学科代表人物和经典作品进行分析,结果...利用知识可视化软件(CiteSpaceⅡ),对Web of Science(SCI,SSCI,A&HCI)中收录的1975—2010年间的988篇知识交流研究论文进行分析,分别对相关文献的时间、地区、机构和期刊分布,主要研究领域以及学科代表人物和经典作品进行分析,结果显示,近年来国外知识交流研究呈总体增长趋势,内容主要涉及三大领域:知识管理、科学社会学和文献计量。通过对主题词突变检测发现,网络知识交流、知识管理、交流理论和医疗知识交流等是知识交流研究的前沿和未来趋势。展开更多
以SCIE、SSCI和A&HCI所收录的国外足球运动体能训练相关文献为研究对象,利用Cite Space II分析软件对1985年至今,国外足球运动体能训练研究的698篇学术论文及其相关参考文献进行科学计量与可视化分析,力图揭示国外足球运动体能训练...以SCIE、SSCI和A&HCI所收录的国外足球运动体能训练相关文献为研究对象,利用Cite Space II分析软件对1985年至今,国外足球运动体能训练研究的698篇学术论文及其相关参考文献进行科学计量与可视化分析,力图揭示国外足球运动体能训练的研究热点与演化进程。研究表明,现阶段国外足球运动体能训练研究的主要力量集中在美欧等发达国家和地区,形成了体育科学主导下多学科交叉综合的复合型学科群,研究演化过程历经探索、拓展、深化及综合等阶段,研究热点主要集中在足球体能训练的整体运动负荷安排与控制、体能训练的信息收集与评价方法、足球运动员的运动性损伤与体能康复、比赛表现特征与体能需求分析以及足球专项体能训练的设计理念与训练方法等方面;众多知识聚类与高影响力科研成果,成为推动足球运动体能训练理论与实践研究演进的动力。展开更多
AIM： To determine factors related to disease severity, mortality and morbidity in acute pancreatitis.METHODS： One hundred and ninety-nine consecutive patients were admitted with the diagnosis of acute pancreatitis ...AIM： To determine factors related to disease severity, mortality and morbidity in acute pancreatitis.METHODS： One hundred and ninety-nine consecutive patients were admitted with the diagnosis of acute pancreatitis （AP） in a 5-year period （1998-2002）. In a prospective design, demographic data, etiology, mean hospital admission time, clinical, radiological, biochemical findings, treatment modalities, mortality and morbidity were recorded. Endocrine insufficiency was investigated with oral glucose tolerance test. The relations between these parameters, scoring systems （Ranson, Imrie and APACHE Ⅱ） and patients＇ outcome were determined by using invariable tests and the receiver operating characteristics curve.RESULTS： One hundred patients were men and 99 were women; the mean age was 55 years. Biliary pancreatitis was the most common form, followed by idiopathic pancreatitis （53% and 26%, respectively）. Sixty-three patients had severe pancreatitis and 136 had mild disease. Respiratory rate 〉 20/min, pulse rate 〉 90min, increased C-reactive protein （CRP）, lactate dehydrogenase （LDH） and aspartate aminotransferase （AST） levels, organ necrosis 〉 30% on computed tornography （CT） and leukocytosis were associated with severe disease. The rate of glucose intolerance, morbidity and mortality were 24.1%, 24.8% and 13.6%, respectively. CRP 〉 142 mg/L, BUN 〉 22 mg/dL, LDH 〉 667 U/L, base excess 〉 -5, CT severity index 〉 3 and APACHE score 〉 8 were related to morbidity and mortality.CONCLUSION： APACHE Ⅱ score, LDH, base excess and CT severity index have prognostic value and CRP is a reliable marker for predicting both mortality and morbidity.展开更多
利用当前最著名的信息可视化分析软件Citespace Ⅱ对从SCI(Thomson.ISI)网络版(web of Science中的科学引文索引扩展版)中下载的1998--2009年间信息可视化研究文献做了详细的可视化分析,厘清了信息可视化研究的演进轨迹,揭示了研究热点...利用当前最著名的信息可视化分析软件Citespace Ⅱ对从SCI(Thomson.ISI)网络版(web of Science中的科学引文索引扩展版)中下载的1998--2009年间信息可视化研究文献做了详细的可视化分析,厘清了信息可视化研究的演进轨迹,揭示了研究热点,探讨了此项研究的国家与研究机构分布情况。展开更多
INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed...INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression vector.The constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱexpression.The biological behavior changes ofhepatoma cells were observed.All these展开更多
BACKGROUND Severe acute pancreatitis(SAP)is a common condition in the intensive care unit(ICU)and has a high mortality.Early evaluation of the severity and prognosis is very important for SAP therapy.Recently,red bloo...BACKGROUND Severe acute pancreatitis(SAP)is a common condition in the intensive care unit(ICU)and has a high mortality.Early evaluation of the severity and prognosis is very important for SAP therapy.Recently,red blood cell distribution(RDW)was associated with mortality of sepsis patients and could be used as a predictor of prognosis.Similarly,RDW may be associated with the prognosis of SAP patients and be used as a prognostic indicator for SAP patients.AIM To investigate the prognostic value of RDW for SAP patients.METHODS We retrospectively enrolled SAP patients admitted to the ICU of the First Affiliated Hospital of China Medical University from June 2015 to June 2017.According to the prognosis at 90 d,SAP patients were divided into a survival group and a non-survival group.RDW was extracted from a routine blood test.Demographic parameters and RDW were recorded and compared between the two groups.The receiver operator characteristic(ROC)curve was constructed and Cox regression analysis was performed to investigate the prognostic value of RDW for SAP patients.RESULTS In this retrospective cohort study,42 SAP patients were enrolled,of whom 22 survived(survival group)and 20 died(non-survival group).The baseline parameters were comparable between the two groups.The coefficient of variation of RDW(RDW-CV),standard deviation of RDW(RDW-SD),Acute Physiology and Chronic Health Evaluation II(APACHE II)score,and Sequential Organ Failure Assessment(SOFA)score were significantly higher in the non-survival group than in the survival group(P<0.05).The RDW-CV and RDW-SD were significantly correlated with the APACHE II score and SOFA score,respectively.The areas under the ROC curves(AUCs)of RDW-CV and RDW-SD were all greater than those of the APACHE II score and SOFA score,among which,the AUC of RDW-SD was the greatest.The results demonstrated that RDW had better prognostic value for predicting the mortality of SAP patients.When the RDW-SD was greater than 45.5,the sensitivity for predicting prognosis was 77.8%and the specifi展开更多
The congenital dyserythropoietic anemias comprise a group of rare hereditary disorders of erythropoiesis, characterized by ineffective erythropoiesis as the predominant mechanism of anemia and by characteristic morpho...The congenital dyserythropoietic anemias comprise a group of rare hereditary disorders of erythropoiesis, characterized by ineffective erythropoiesis as the predominant mechanism of anemia and by characteristic morphological aberrations of the majority of erythroblasts in the bone marrow. Congenital dyserythropoietic anemia type II is the most frequent type. All types of congenital dyserythropoietic anemias distinctly share a high incidence of iron loading. Iron accumulation occurs even in untransfused patients and can result in heart failure and liver cirrhosis. We have reported about a patient who presented with liver cirrhosis and intractable ascites caused by congenital dyserythropoietic anemia type II. Her clinical course was further complicated by the development of autoimmune hemolytic anemia. Splenectomy was eventually performed which achieved complete resolution of ascites, increase of hemoglobin concentration and abrogation of transfusion requirements.展开更多
AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl<sub>;</sub>and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND...AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl<sub>;</sub>and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing（180±20）g,wererandomized into five groups（control group,modelgroup,and three losartan treated groups）,inwhich all rats were given the subcutaneousinjection of 40% CCl<sub>4</sub>（every 3 days for 6 weeks）except for rats of control group.Rats of losartan-treated groups were treated with losartan（20 mg/kg,10 mg/kg,5 mg/kg,daily gavage）,After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid（HA）,procollagen typeⅢ（PCⅢ）were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta（TGF-β）,and alpha-smooth muscle actin（a-SMA）inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced（t=4.20,P【0.01 and t=4.57,P【0.01）.Serum HAand PCⅢalso had significant differences（t=3.53,P【0.01 and t=2.20,P【0.05）.Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl<sub>4</sub>.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors.展开更多
文摘利用知识可视化软件(CiteSpaceⅡ),对Web of Science(SCI,SSCI,A&HCI)中收录的1975—2010年间的988篇知识交流研究论文进行分析,分别对相关文献的时间、地区、机构和期刊分布,主要研究领域以及学科代表人物和经典作品进行分析,结果显示,近年来国外知识交流研究呈总体增长趋势,内容主要涉及三大领域:知识管理、科学社会学和文献计量。通过对主题词突变检测发现,网络知识交流、知识管理、交流理论和医疗知识交流等是知识交流研究的前沿和未来趋势。
文摘以SCIE、SSCI和A&HCI所收录的国外足球运动体能训练相关文献为研究对象,利用Cite Space II分析软件对1985年至今,国外足球运动体能训练研究的698篇学术论文及其相关参考文献进行科学计量与可视化分析,力图揭示国外足球运动体能训练的研究热点与演化进程。研究表明,现阶段国外足球运动体能训练研究的主要力量集中在美欧等发达国家和地区,形成了体育科学主导下多学科交叉综合的复合型学科群,研究演化过程历经探索、拓展、深化及综合等阶段,研究热点主要集中在足球体能训练的整体运动负荷安排与控制、体能训练的信息收集与评价方法、足球运动员的运动性损伤与体能康复、比赛表现特征与体能需求分析以及足球专项体能训练的设计理念与训练方法等方面;众多知识聚类与高影响力科研成果,成为推动足球运动体能训练理论与实践研究演进的动力。
文摘AIM： To determine factors related to disease severity, mortality and morbidity in acute pancreatitis.METHODS： One hundred and ninety-nine consecutive patients were admitted with the diagnosis of acute pancreatitis （AP） in a 5-year period （1998-2002）. In a prospective design, demographic data, etiology, mean hospital admission time, clinical, radiological, biochemical findings, treatment modalities, mortality and morbidity were recorded. Endocrine insufficiency was investigated with oral glucose tolerance test. The relations between these parameters, scoring systems （Ranson, Imrie and APACHE Ⅱ） and patients＇ outcome were determined by using invariable tests and the receiver operating characteristics curve.RESULTS： One hundred patients were men and 99 were women; the mean age was 55 years. Biliary pancreatitis was the most common form, followed by idiopathic pancreatitis （53% and 26%, respectively）. Sixty-three patients had severe pancreatitis and 136 had mild disease. Respiratory rate 〉 20/min, pulse rate 〉 90min, increased C-reactive protein （CRP）, lactate dehydrogenase （LDH） and aspartate aminotransferase （AST） levels, organ necrosis 〉 30% on computed tornography （CT） and leukocytosis were associated with severe disease. The rate of glucose intolerance, morbidity and mortality were 24.1%, 24.8% and 13.6%, respectively. CRP 〉 142 mg/L, BUN 〉 22 mg/dL, LDH 〉 667 U/L, base excess 〉 -5, CT severity index 〉 3 and APACHE score 〉 8 were related to morbidity and mortality.CONCLUSION： APACHE Ⅱ score, LDH, base excess and CT severity index have prognostic value and CRP is a reliable marker for predicting both mortality and morbidity.
文摘利用当前最著名的信息可视化分析软件Citespace Ⅱ对从SCI(Thomson.ISI)网络版(web of Science中的科学引文索引扩展版)中下载的1998--2009年间信息可视化研究文献做了详细的可视化分析,厘清了信息可视化研究的演进轨迹,揭示了研究热点,探讨了此项研究的国家与研究机构分布情况。
基金the National Natural Science Foundation of Guangdong Province,No.940319.
文摘INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression vector.The constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱexpression.The biological behavior changes ofhepatoma cells were observed.All these
基金Supported by Health and Birth Control Committee of Liaoning Province,China
文摘BACKGROUND Severe acute pancreatitis(SAP)is a common condition in the intensive care unit(ICU)and has a high mortality.Early evaluation of the severity and prognosis is very important for SAP therapy.Recently,red blood cell distribution(RDW)was associated with mortality of sepsis patients and could be used as a predictor of prognosis.Similarly,RDW may be associated with the prognosis of SAP patients and be used as a prognostic indicator for SAP patients.AIM To investigate the prognostic value of RDW for SAP patients.METHODS We retrospectively enrolled SAP patients admitted to the ICU of the First Affiliated Hospital of China Medical University from June 2015 to June 2017.According to the prognosis at 90 d,SAP patients were divided into a survival group and a non-survival group.RDW was extracted from a routine blood test.Demographic parameters and RDW were recorded and compared between the two groups.The receiver operator characteristic(ROC)curve was constructed and Cox regression analysis was performed to investigate the prognostic value of RDW for SAP patients.RESULTS In this retrospective cohort study,42 SAP patients were enrolled,of whom 22 survived(survival group)and 20 died(non-survival group).The baseline parameters were comparable between the two groups.The coefficient of variation of RDW(RDW-CV),standard deviation of RDW(RDW-SD),Acute Physiology and Chronic Health Evaluation II(APACHE II)score,and Sequential Organ Failure Assessment(SOFA)score were significantly higher in the non-survival group than in the survival group(P<0.05).The RDW-CV and RDW-SD were significantly correlated with the APACHE II score and SOFA score,respectively.The areas under the ROC curves(AUCs)of RDW-CV and RDW-SD were all greater than those of the APACHE II score and SOFA score,among which,the AUC of RDW-SD was the greatest.The results demonstrated that RDW had better prognostic value for predicting the mortality of SAP patients.When the RDW-SD was greater than 45.5,the sensitivity for predicting prognosis was 77.8%and the specifi
文摘The congenital dyserythropoietic anemias comprise a group of rare hereditary disorders of erythropoiesis, characterized by ineffective erythropoiesis as the predominant mechanism of anemia and by characteristic morphological aberrations of the majority of erythroblasts in the bone marrow. Congenital dyserythropoietic anemia type II is the most frequent type. All types of congenital dyserythropoietic anemias distinctly share a high incidence of iron loading. Iron accumulation occurs even in untransfused patients and can result in heart failure and liver cirrhosis. We have reported about a patient who presented with liver cirrhosis and intractable ascites caused by congenital dyserythropoietic anemia type II. Her clinical course was further complicated by the development of autoimmune hemolytic anemia. Splenectomy was eventually performed which achieved complete resolution of ascites, increase of hemoglobin concentration and abrogation of transfusion requirements.
文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl<sub>;</sub>and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing（180±20）g,wererandomized into five groups（control group,modelgroup,and three losartan treated groups）,inwhich all rats were given the subcutaneousinjection of 40% CCl<sub>4</sub>（every 3 days for 6 weeks）except for rats of control group.Rats of losartan-treated groups were treated with losartan（20 mg/kg,10 mg/kg,5 mg/kg,daily gavage）,After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid（HA）,procollagen typeⅢ（PCⅢ）were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta（TGF-β）,and alpha-smooth muscle actin（a-SMA）inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced（t=4.20,P【0.01 and t=4.57,P【0.01）.Serum HAand PCⅢalso had significant differences（t=3.53,P【0.01 and t=2.20,P【0.05）.Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl<sub>4</sub>.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors.
