The DMAP-catalyzed [4＋2] cycloaddition of α,β-unsaturated carboxylic acids with ketones furnishing α,β-unsaturated δ-lactones in good yields （up to 80%） is described, which is the first example of remote -C（s...The DMAP-catalyzed [4＋2] cycloaddition of α,β-unsaturated carboxylic acids with ketones furnishing α,β-unsaturated δ-lactones in good yields （up to 80%） is described, which is the first example of remote -C（sp^3）-H activation of α,β-unsaturated carboxylic acids facilitated by DMAP, a pyridine-based catalyst.展开更多
Direct chemoselective oxidation of δ-lactones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl-1-naphthoic acid in the presenc...Direct chemoselective oxidation of δ-lactones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl-1-naphthoic acid in the presence of K2S2Os--CuCl2 results to the δ-lactones in moderate to good yields. The advantages of this methodology is using water as a solvent and utilizing available starting materials.展开更多
以黄酮类化合物生物合成过程中的两个关键酶:4-香豆酰辅酶A连接酶(4-coumarate coenzyme A ligase,4CL)和查尔酮合成酶(chalcone synthase,CHS)为工具酶,探讨酶催化组合合成在合成"非天然的天然产物"群(库)中的应用.结果发现...以黄酮类化合物生物合成过程中的两个关键酶:4-香豆酰辅酶A连接酶(4-coumarate coenzyme A ligase,4CL)和查尔酮合成酶(chalcone synthase,CHS)为工具酶,探讨酶催化组合合成在合成"非天然的天然产物"群(库)中的应用.结果发现在4CL和CHS的共同作用下,仅利用8个简单的有机酸就可以产生包括8个黄酮类似物、16个4-羟基-δ-内酯和1个苄基丙酮共计25个"非天然的天然产物"群,为构建结构多样的小分子化合物群(库)提供方法学参考.展开更多
基金This work is supported by the National Natural Science Foundation of China （No. 21372074）.
文摘The DMAP-catalyzed [4＋2] cycloaddition of α,β-unsaturated carboxylic acids with ketones furnishing α,β-unsaturated δ-lactones in good yields （up to 80%） is described, which is the first example of remote -C（sp^3）-H activation of α,β-unsaturated carboxylic acids facilitated by DMAP, a pyridine-based catalyst.
文摘Direct chemoselective oxidation of δ-lactones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl-1-naphthoic acid in the presence of K2S2Os--CuCl2 results to the δ-lactones in moderate to good yields. The advantages of this methodology is using water as a solvent and utilizing available starting materials.
文摘以黄酮类化合物生物合成过程中的两个关键酶:4-香豆酰辅酶A连接酶(4-coumarate coenzyme A ligase,4CL)和查尔酮合成酶(chalcone synthase,CHS)为工具酶,探讨酶催化组合合成在合成"非天然的天然产物"群(库)中的应用.结果发现在4CL和CHS的共同作用下,仅利用8个简单的有机酸就可以产生包括8个黄酮类似物、16个4-羟基-δ-内酯和1个苄基丙酮共计25个"非天然的天然产物"群,为构建结构多样的小分子化合物群(库)提供方法学参考.
