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β-羟基-β-甲基丁酸在猪生产中的应用及其作用机制 被引量:1
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作者 万海峰 孙鹏 +5 位作者 黄琼 吴高岭 钟铭 伍剑 左晓灵 吴德 《饲料工业》 北大核心 2023年第13期42-48,共7页
β-羟基-β-甲基丁酸(HMB)是亮氨酸的一种代谢产物。研究发现,HMB通过母体调节仔猪肌纤维的生长发育,改善了仔猪生长性能及上市期肉品质。同时,HMB通过提高母猪初乳脂肪及免疫球蛋白含量改善哺乳仔猪成活率。而且HMB有利于促进仔猪断奶... β-羟基-β-甲基丁酸(HMB)是亮氨酸的一种代谢产物。研究发现,HMB通过母体调节仔猪肌纤维的生长发育,改善了仔猪生长性能及上市期肉品质。同时,HMB通过提高母猪初乳脂肪及免疫球蛋白含量改善哺乳仔猪成活率。而且HMB有利于促进仔猪断奶后生长,缓解断奶应激。HMB影响母仔猪生产性能的机制是通过促进仔猪胎儿期肌纤维生肌作用、新生期肌纤维类型转换,以及促进仔猪骨骼肌蛋白合成,并在断奶应激下抑制肌肉蛋白质分解途径等来实现。 展开更多
关键词 β-羟基-β-甲基丁酸 肌纤维发育 母猪 仔猪 作用机制
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β-hydroxy-β-methylbutyrate Improves Chronic Renal Failure-Induced Sarcopenia in SD Rats by Regulating Autophagy 被引量:4
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作者 Zun Yue Zhang Liu Qing Yang +4 位作者 Ya Nan Yang Yun Lin Wang Long Mei Zhang Kun Hua Wang Min Weng 《Journal of Nutritional Oncology》 2021年第4期186-195,共10页
Background Chronic renal failure-induced sarcopenia(CRF-S)seriously affects public health by increasing morbidity and mortality.This study evaluated the therapeutic effects ofβ-hydroxy-β-methylbutyrate acid(HMB)and ... Background Chronic renal failure-induced sarcopenia(CRF-S)seriously affects public health by increasing morbidity and mortality.This study evaluated the therapeutic effects ofβ-hydroxy-β-methylbutyrate acid(HMB)and the underlying mechanism in an adenine-induced CRF-S rat model.Methods Sprague Dawley rats were divided into control,model(CRF-S),and HMB treatment(CRF-S+HMB)groups.The rats in the CRF-S group received 250 mg/kg/d adenine by oral gavage every day for 14 days,followed by administration every other day until the 28th day.In the CRF-S+HMB group,each rat was given 320 mg/kg/d HMB by oral gavage starting from 7 days prior to adenine treatment,and this treatment was maintained for a total of 35 days.The body weight,right anterior tibial muscle weight,blood serum parameters,gastrocnemius muscle and renal tissue histology,and expression of autophagy-related transcripts and proteins were evaluated.Results A rat model of CRF-S was successfully established via adenine gavage,as indicated by reduced body weight and muscle weights,and markers of sarcopenia.There were increased mRNA levels of LC3B,Beclin1,Ulk1,Atg5,Atg7,Atg13 and vps-34,and increased protein expression levels of LC3B and P62.In the rats with HMB intervention,the body weight,right anterior tibial weight and gastrocnemius muscle histology were not significantly different from those in the control group,and the expression levels of autophagy-related proteins(LC3B and P62)were consistent with those in the control group.Conclusion We successfully established a rat model of CRF-S using adenine administered via oral gavage,and observed that HMB treatment prevented CRF-S. 展开更多
关键词 SARCOPENIA Chronic renal failure β-hydroxy-β-methylbutyrate(hmb) AUTOPHAGY
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β-羟基-β-甲基丁酸盐(HMB)运动功效的研究进展 被引量:1
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作者 刘小杰 许建超 +1 位作者 李娜 孙敏 《中国食品添加剂》 CAS 北大核心 2021年第6期132-138,共7页
β-羟基-β-甲基丁酸盐(HMB)是亮氨酸的代谢中间产物,国内外大量的动物和临床试验证明:HMB具有促进肌肉蛋白质合成、抑制肌肉蛋白质分解、维持瘦体重、提高运动能力、维护细胞膜完整性、提高免疫功能和降低炎症反应等作用。本文对HMB的... β-羟基-β-甲基丁酸盐(HMB)是亮氨酸的代谢中间产物,国内外大量的动物和临床试验证明:HMB具有促进肌肉蛋白质合成、抑制肌肉蛋白质分解、维持瘦体重、提高运动能力、维护细胞膜完整性、提高免疫功能和降低炎症反应等作用。本文对HMB的作用机制,特别是HMB与运动和肌肉减少症之间的关系进行了回顾,为其应用于运动营养食品和功能性食品奠定一定的理论基础。 展开更多
关键词 β-羟基-β-甲基丁酸盐 抗阻训练 肌肉损伤 肌肉减少症 运动能力
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