IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis. 1 The histopathology of IgAN is characterized by abundance of mesangial matrix and proliferation of mesangial cells. IgA_1 deposition in t...IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis. 1 The histopathology of IgAN is characterized by abundance of mesangial matrix and proliferation of mesangial cells. IgA_1 deposition in the mesangium plays an important role in the inflammatory process in this disease.展开更多
This paper provides an analytic performance evaluation of dual-hop cognitive amplify-and-forward (AF) relaying networks over independent nonidentically distributed (i.n.i.d.) fading channels. Two different transmit po...This paper provides an analytic performance evaluation of dual-hop cognitive amplify-and-forward (AF) relaying networks over independent nonidentically distributed (i.n.i.d.) fading channels. Two different transmit power constraint strategies at the secondary network are proposed to investigate the performance of the secondary network. In the case of combined power constraint,the maximum tolerable interference power on the primary network and the maximum transmit power at the secondary network are considered. Closed-form lower bound and its asymptotic expression for the outage probability (OP) are achieved. Utilizing the above results,average symbol error probability (ABEP) at high signal-to-noise ratios (SNRs) are also derived. In order to further study the performance of dual-hop cognitive AF relaying networks,the Closed-form lower bounds and asymptotic expressions for OP with single power constraint of the tolerable interference on the primary network is also obtained. Both analytical and simulation are employed to validate the accuracy of the theoretical analysis. The results show that the secondary network obtains a better performance when higher power constraint is employed.展开更多
This paper derives new and exact closed-form expressions for the average symbol error rate(SER) of square M-ary quadrature amplitude modulation(M-QAM) in wireless communication systems over theα-μfading channels sub...This paper derives new and exact closed-form expressions for the average symbol error rate(SER) of square M-ary quadrature amplitude modulation(M-QAM) in wireless communication systems over theα-μfading channels subject to an additive non-Gaussian noise. The obtained expressions take into account static and mobile wireless receivers. In addition, a closed-form expression for the outage probability in mobile networks is obtained. Please note that all derived expressions in this paper a valid for integer and non-integer values of the fading parameters. Analytical results are presented to study the impact of noise shaping parameter, severity of fading, and mobility on the average SER. Monte-Carlo simulations results are also provided to validate the accuracy of the analytical results.展开更多
针对相关Nakagami衰落等增益合并(equal gain combining,EGC)分集系统性能不存在精确解析式的问题,提出一种基于矩匹配的高效近似分析方法.该方法将各支路信号等增益叠加后的复杂衰落近似等价为α-μ分布,利用α-μ变量的统计特性获得...针对相关Nakagami衰落等增益合并(equal gain combining,EGC)分集系统性能不存在精确解析式的问题,提出一种基于矩匹配的高效近似分析方法.该方法将各支路信号等增益叠加后的复杂衰落近似等价为α-μ分布,利用α-μ变量的统计特性获得分集系统的信噪比分布、中断概率和平均误符号率等性能表达式.仿真结果表明,该方法实现简单,计算结果与理论值非常接近,可应用于多种信道衰落下EGC分集系统的参数设计和性能评估.展开更多
Objective To explore the role and the possible molecular mechanisms of natural anti-oxLDL IgM monoclonal antibody played and involved in pathogenesis of atherosclerosis. Methods Natural anti-oxLDL IgM monoclonal antib...Objective To explore the role and the possible molecular mechanisms of natural anti-oxLDL IgM monoclonal antibody played and involved in pathogenesis of atherosclerosis. Methods Natural anti-oxLDL IgM monoclonal antibody 3A6 was generated by using standard hybridoma production techniques. Influence of 3A6 on formation of foam cells was observed by Oil Red O staining and affinity of Na125I-conjugated oxLDL on the naive and LPS-activated macrophages. After LPS stimulation on macrophages, anti-TLR4 neutralizing mAb, p38MAPK specific inhibitor SB203580, NF-kB specific inhibitor PDTC or RNAi targeting Fcα/μ receptor (Fcamr) were applied, respectively. Results Natural anti-oxLDL IgM monoclonal antibody 3 A6 were found specifically inhibit the binding of CuoxLDL to naive macrophages but not the binding of CuoxLDL to LPS-activated macrophages. It also promoted the formation of CuoxLDL-mediated foam macrophages. 3A6 F(ab')2 or pre-incubation with un-related IgM inhibited the binding of 3A6/CuoxLDL complex to LPS-activated macrophages. LPS up-regulated the expression of Fcamr in macrophages in a dose- and time-dependent manner, which was attenuated by treatment with anti-TLR4. LPS induced the phosphorylation of p38MAPK and translocation of NF-kB p65, contributing to the up-regulated expression of Fcα/μ receptor in macrophages. Conclusions Natural anti-oxLDL IgM monoclonal antibody 3A6 specifically inhibited the binding of CuoxLDL to naive macrophages in vitro. However, LPS, through the Toll-like receptor (TLR)4 receptor, activated the p38MAPK and NF-kB pathways and up-regulated the expression of Fcα/μ receptor in macrophages, which promoted the binding of 3A6/CuoxLDL complex to macrophages through binding with Fc fragments and the formation of foam macrophages. Therefore, our findings provide a new explanation why bacterial infection deteriorates the pathogenesis of atherosclerosis.展开更多
This paper analyzes the unified performance of energy detection(ED) of spectrum sensing(SS) over generalized fading channels in cognitive radios(CRs). The detective performance of SS will be obviously affected by fadi...This paper analyzes the unified performance of energy detection(ED) of spectrum sensing(SS) over generalized fading channels in cognitive radios(CRs). The detective performance of SS will be obviously affected by fading channels among communication nodes, and ED has the advantages of fast implementation, no requirement of priori received information and low complexity, so it is meaningful to investigate ED over various fading channels. The probability density function(p.d.f.) of α-κ-μ distribution is derived to evaluate energy efficiency for sensing systems.The detection probability with Marcum-Q function has been derived and the close-form expressions with moment generating function(MGF) method are deduced to achieve SS.Furthermore, exact closed-form analytic expressions for average area under the receiver operating characteristics curve( AUC) also have been deduced to analyze the performance characteristics of ED over α-κ-μ fading channels.Besides, cooperative spectrum sensing(CSS) with diversity reception has been applied to improve the detection accuracy and mitigate the shadowed fading features with OR-rule. At last, the results show that the detection capacity of ED will be evidently affected by α-κ-μ fading channels, but appropriate channel parameters can improve sensing performance. In addition, the establishedED-fading pattern is approved by simulations,and it can significantly enhance the detection performance of proposed algorithms.展开更多
基金ThestudywassupportedbyNational"211 Project"inPekingUniversityandtheSpecialFundforPromotionofEducationMinistryofEducation China
文摘IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis. 1 The histopathology of IgAN is characterized by abundance of mesangial matrix and proliferation of mesangial cells. IgA_1 deposition in the mesangium plays an important role in the inflammatory process in this disease.
基金National Natural Science Foundation of China(No.61461024)
文摘This paper provides an analytic performance evaluation of dual-hop cognitive amplify-and-forward (AF) relaying networks over independent nonidentically distributed (i.n.i.d.) fading channels. Two different transmit power constraint strategies at the secondary network are proposed to investigate the performance of the secondary network. In the case of combined power constraint,the maximum tolerable interference power on the primary network and the maximum transmit power at the secondary network are considered. Closed-form lower bound and its asymptotic expression for the outage probability (OP) are achieved. Utilizing the above results,average symbol error probability (ABEP) at high signal-to-noise ratios (SNRs) are also derived. In order to further study the performance of dual-hop cognitive AF relaying networks,the Closed-form lower bounds and asymptotic expressions for OP with single power constraint of the tolerable interference on the primary network is also obtained. Both analytical and simulation are employed to validate the accuracy of the theoretical analysis. The results show that the secondary network obtains a better performance when higher power constraint is employed.
基金the support of SNCS Research Center and the Deanship of Scientific Research at the University of Tabukfinancial and inkind support for the project no. S-1438-0161
文摘This paper derives new and exact closed-form expressions for the average symbol error rate(SER) of square M-ary quadrature amplitude modulation(M-QAM) in wireless communication systems over theα-μfading channels subject to an additive non-Gaussian noise. The obtained expressions take into account static and mobile wireless receivers. In addition, a closed-form expression for the outage probability in mobile networks is obtained. Please note that all derived expressions in this paper a valid for integer and non-integer values of the fading parameters. Analytical results are presented to study the impact of noise shaping parameter, severity of fading, and mobility on the average SER. Monte-Carlo simulations results are also provided to validate the accuracy of the analytical results.
文摘针对相关Nakagami衰落等增益合并(equal gain combining,EGC)分集系统性能不存在精确解析式的问题,提出一种基于矩匹配的高效近似分析方法.该方法将各支路信号等增益叠加后的复杂衰落近似等价为α-μ分布,利用α-μ变量的统计特性获得分集系统的信噪比分布、中断概率和平均误符号率等性能表达式.仿真结果表明,该方法实现简单,计算结果与理论值非常接近,可应用于多种信道衰落下EGC分集系统的参数设计和性能评估.
文摘Objective To explore the role and the possible molecular mechanisms of natural anti-oxLDL IgM monoclonal antibody played and involved in pathogenesis of atherosclerosis. Methods Natural anti-oxLDL IgM monoclonal antibody 3A6 was generated by using standard hybridoma production techniques. Influence of 3A6 on formation of foam cells was observed by Oil Red O staining and affinity of Na125I-conjugated oxLDL on the naive and LPS-activated macrophages. After LPS stimulation on macrophages, anti-TLR4 neutralizing mAb, p38MAPK specific inhibitor SB203580, NF-kB specific inhibitor PDTC or RNAi targeting Fcα/μ receptor (Fcamr) were applied, respectively. Results Natural anti-oxLDL IgM monoclonal antibody 3 A6 were found specifically inhibit the binding of CuoxLDL to naive macrophages but not the binding of CuoxLDL to LPS-activated macrophages. It also promoted the formation of CuoxLDL-mediated foam macrophages. 3A6 F(ab')2 or pre-incubation with un-related IgM inhibited the binding of 3A6/CuoxLDL complex to LPS-activated macrophages. LPS up-regulated the expression of Fcamr in macrophages in a dose- and time-dependent manner, which was attenuated by treatment with anti-TLR4. LPS induced the phosphorylation of p38MAPK and translocation of NF-kB p65, contributing to the up-regulated expression of Fcα/μ receptor in macrophages. Conclusions Natural anti-oxLDL IgM monoclonal antibody 3A6 specifically inhibited the binding of CuoxLDL to naive macrophages in vitro. However, LPS, through the Toll-like receptor (TLR)4 receptor, activated the p38MAPK and NF-kB pathways and up-regulated the expression of Fcα/μ receptor in macrophages, which promoted the binding of 3A6/CuoxLDL complex to macrophages through binding with Fc fragments and the formation of foam macrophages. Therefore, our findings provide a new explanation why bacterial infection deteriorates the pathogenesis of atherosclerosis.
基金supported by the science and technology project of state grid headquarters of China (SGLNDK00KJJS1700200)
文摘This paper analyzes the unified performance of energy detection(ED) of spectrum sensing(SS) over generalized fading channels in cognitive radios(CRs). The detective performance of SS will be obviously affected by fading channels among communication nodes, and ED has the advantages of fast implementation, no requirement of priori received information and low complexity, so it is meaningful to investigate ED over various fading channels. The probability density function(p.d.f.) of α-κ-μ distribution is derived to evaluate energy efficiency for sensing systems.The detection probability with Marcum-Q function has been derived and the close-form expressions with moment generating function(MGF) method are deduced to achieve SS.Furthermore, exact closed-form analytic expressions for average area under the receiver operating characteristics curve( AUC) also have been deduced to analyze the performance characteristics of ED over α-κ-μ fading channels.Besides, cooperative spectrum sensing(CSS) with diversity reception has been applied to improve the detection accuracy and mitigate the shadowed fading features with OR-rule. At last, the results show that the detection capacity of ED will be evidently affected by α-κ-μ fading channels, but appropriate channel parameters can improve sensing performance. In addition, the establishedED-fading pattern is approved by simulations,and it can significantly enhance the detection performance of proposed algorithms.
