Objective:Glucagon-like peptide-1 receptor imaging,using 68Ga-NOTA-exendin-4 is recently established for detecting insulinomas.Owing to the highly radioactive kidneys in 68Ga-NOTA-exendin-4 PET/CT,we aimed to determin...Objective:Glucagon-like peptide-1 receptor imaging,using 68Ga-NOTA-exendin-4 is recently established for detecting insulinomas.Owing to the highly radioactive kidneys in 68Ga-NOTA-exendin-4 PET/CT,we aimed to determine the effectiveness of Gelofusine in reducing renal uptake of 68Ga-NOTA-exendin-4.Methods:In our randomized controlled study,patients presenting for 68Ga-NOTA-exendin-4 PET/CT who were18 years and with normal renal function were enrolled,and then randomized into intervention group and control group.Patients in intervention group(group 1)underwent infusion of 500mL Gelofusine prior to PET/CT procedures:patients injected with 68Ga-NOTA-exendin-4(group 1a)immediately after 500mL Gelofusine infusion was completed;(group 1b)at the time point that 250 to 300mL Gelofusine infusion was completed;(group 1c)30minutes after completion of 500mL Gelofusine infusion.The control group(group 2)received 500mL 5%glucose saline instead.PET/CT was then performed,and SUVs of the kidneys and insulinomas were measured.Results:A total of 28 patients were recruited.There were 7 patients(14 kidneys)in each subgroup.The age,body weight,BMI,renal function,injected 68Ga-exendin-4 activity,and interval between injection of the tracer and PET/CT scan were not significantly different among the groups(P>.05).The average and maximum SUVs in the kidneys were significantly reduced in patients of intervention group compared with the control subjects(P<.0001),and the renal uptake could be decreased by 57%with Gelofusine pretreatment.No significant difference in the renal radioactivity was found among group 1a,1b,and 1c(P=.071).The uptake of insulinomas was not significantly different between the intervention and control groups.Conclusion:Renal uptake of 68Ga-exendin-4 can be effectively reduced by pretreatment with Gelofusine.Abbreviations:GLP-1R=Glucagon-like peptide-1 receptor;PRRT=peptide receptor radionuclide therapy;PET=positron emission tomography;SUV=standard uptake value.展开更多
基金supported by National Natural Science Foundation of China(81501515).
文摘Objective:Glucagon-like peptide-1 receptor imaging,using 68Ga-NOTA-exendin-4 is recently established for detecting insulinomas.Owing to the highly radioactive kidneys in 68Ga-NOTA-exendin-4 PET/CT,we aimed to determine the effectiveness of Gelofusine in reducing renal uptake of 68Ga-NOTA-exendin-4.Methods:In our randomized controlled study,patients presenting for 68Ga-NOTA-exendin-4 PET/CT who were18 years and with normal renal function were enrolled,and then randomized into intervention group and control group.Patients in intervention group(group 1)underwent infusion of 500mL Gelofusine prior to PET/CT procedures:patients injected with 68Ga-NOTA-exendin-4(group 1a)immediately after 500mL Gelofusine infusion was completed;(group 1b)at the time point that 250 to 300mL Gelofusine infusion was completed;(group 1c)30minutes after completion of 500mL Gelofusine infusion.The control group(group 2)received 500mL 5%glucose saline instead.PET/CT was then performed,and SUVs of the kidneys and insulinomas were measured.Results:A total of 28 patients were recruited.There were 7 patients(14 kidneys)in each subgroup.The age,body weight,BMI,renal function,injected 68Ga-exendin-4 activity,and interval between injection of the tracer and PET/CT scan were not significantly different among the groups(P>.05).The average and maximum SUVs in the kidneys were significantly reduced in patients of intervention group compared with the control subjects(P<.0001),and the renal uptake could be decreased by 57%with Gelofusine pretreatment.No significant difference in the renal radioactivity was found among group 1a,1b,and 1c(P=.071).The uptake of insulinomas was not significantly different between the intervention and control groups.Conclusion:Renal uptake of 68Ga-exendin-4 can be effectively reduced by pretreatment with Gelofusine.Abbreviations:GLP-1R=Glucagon-like peptide-1 receptor;PRRT=peptide receptor radionuclide therapy;PET=positron emission tomography;SUV=standard uptake value.
