By taking equivalent thermal resistance, which reflects the average heat conduc- tion effect and is defined based on entransy dissipation, as optimization objective, the "volume to point" constructal problem...By taking equivalent thermal resistance, which reflects the average heat conduc- tion effect and is defined based on entransy dissipation, as optimization objective, the "volume to point" constructal problem of how to discharge the heat generated in a fixed volume to a heat sink on the border through relatively high conductive link is re-analyzed and re-optimized in this paper. The constructal shape of the control volume with the best average heat conduction effect is deduced. For the elemental area and the first order construct assembly, when the thermal current density in the high conductive link is linear with the length, the optimized shapes of assemble based on the minimization of entransy dissipation are the same as those based on minimization of maximum temperature difference, and the mean tem- perature difference is 2/3 of the maximum temperature difference. For the second and higher order construct assemblies, the thermal current densities in the high conductive link are not linear with the length, and the optimized shapes of assem- ble based on the minimization of entransy dissipation are different from those based on minimization of maximum temperature difference. For the same parame- ters, the constructs based on minimization of entransy dissipation and the con- structs based on minimization of maximum temperature difference are compared, and the results show that the constructs based on entransy dissipation can de- crease the mean temperature difference better than the constructs based on mini- mization of maximum temperature difference. But with the increase of the number of the order, the mean temperature difference does not always decrease, and there exist some fluctuations. Because the idea of entransy describes the heat transfer ability more suitably, all of the heat conduction constructal problems may be re-optimized based on it.展开更多
The effects of granulocyte colony-stimulation-factor （G-CSF） on stem cell mobilization and its impact on the amplification of myeloid-derived suppressor cells （MDSCs） of donor mice were ex- amined. A mouse model o...The effects of granulocyte colony-stimulation-factor （G-CSF） on stem cell mobilization and its impact on the amplification of myeloid-derived suppressor cells （MDSCs） of donor mice were ex- amined. A mouse model of stem cell mobilization was established by consecutive subcutaneous injec- tion of 100 μg/kg G-CSF for 5 days. The blood from the donor mice was routinely examined during mobilization. Stem cells and MDSCs were analyzed by flow cytometry. The immunosuppressive mole- cules derived from MDSCs in serum and spleen, including hydrogen dioxide （H202） and nitric oxide （NO）, and the activity of nitric oxide synthase （NOS） were determined during the mobilization. Apop- tosis of T lymphocytes was assessed by using Annexin-V/PI. During stem cell mobilization, the number of lymphocytes and white blood cells in the peripheral blood was increased, and peaked on the 4th day. The number of stem cells in G-CSF-treated mice was significantly greater than that in controls （P〈0.01）. The expansions of MSDCs were also observed after G-CSF mobilization, with a more notable rate of growth in the peripheral blood than in the spleen. The activity of NOS and the production of NO were increased in the donor mice, and the serum H202 levels were approximately 4-fold greater than the con- trois. Consequently, apoptosis of T lymphocytes was increased and showed a positive correlation with the elevated percentage of MDSCs. It was concluded that G-CSF could provide sufficient peripheral blood stem cells for transplantation. Exogenous administration of G-CSF caused the accumulation of MDSCs in the peripheral blood and the spleen, which could lead to apoptosis ofT lymphocytes and may offer a new strategy for the prevention and treatment of graft versus host disease.展开更多
In order to optimize test flow after the default flow is modified by a tester, a new software framework for the radar fault isolation is illustrated. This framework separates all mapping algorithms from test flows so ...In order to optimize test flow after the default flow is modified by a tester, a new software framework for the radar fault isolation is illustrated. This framework separates all mapping algorithms from test flows so as to modify flow and to insert mapping algorithm dynamically in testing process. Based on this framework, a kind of optimization method of test flow is proposed and studied. By defining an objective function, we can evaluate all candidate test flows so as to get an optimized flow. An example explains how to search the flow from candidate flows.展开更多
Hybrid optical switching networks make full use of the advantages of Optical Circuit Switching(OCS)and Optical Burst Switching(OBS).In parallel hybrid optical switching networks,edge nodes choose a switching mode for ...Hybrid optical switching networks make full use of the advantages of Optical Circuit Switching(OCS)and Optical Burst Switching(OBS).In parallel hybrid optical switching networks,edge nodes choose a switching mode for traffic and no longer change.The inflexible decision making of the traffic transfer mode leads to low resource utilization when the arrival rate of the OCS traffic is lower than the capacity of the light path.In this paper,a new transmission scheme is proposed to improve resource utilization for hybrid optical switching networks.When the traffic arrival rate of the light path is lower than the transmission rate of the light path,the OCS traffic flow is reshaped at the edge nodes to generate a series of voids.Then,several message packets are sent along the light path to inform the core nodes of the voids of the light paths that represent the unused bandwidth resources.To improve the resource utilization,the voids can be filled with data bursts by core nodes.The simulation results show that the new scheme can effectively reduce the burst loss rate and improve the link utilization of the hybrid optical switching network on the premise of a providing service quality guarantee for OCS traffic.展开更多
The electrical properties of chemically derived graphene and graphene grown by chemical vapor deposition （CVD）, until now, have been inferior to those of mechanically exfoliated graphene. However, because graphene i...The electrical properties of chemically derived graphene and graphene grown by chemical vapor deposition （CVD）, until now, have been inferior to those of mechanically exfoliated graphene. However, because graphene is easier to produce in large quantities through CVD or growth from solid carbon sources, it has a higher potential for use in future electronics applications. Generally, modifications to the pristine lattice structure of graphene tend to adversely affect the electrical properties by shifting the doping level and changing the conductivity and the mobility. Here we show that a small degree of graphene surface functionalization, using diazonium salts with electron-withdrawing and electron-donating functional groups, is sufficient to predominantly induce p-type doping, undiminished mobility, and higher conductivity at the neutrality point. Molecules without a diazonium anchor group desorb easily and do not have a significant effect on the electronic properties of graphene devices. We further demonstrate the variability between identically fabricated pristine devices, thereby underscoring the caution needed when characterizing graphene device behaviors lest conclusions be drawn based on singular extremes.展开更多
基金Supported by the Program for New Century Excellent Talents in University of Chinathe Foundation for the Author of National Excellent Doctoral Dissertation of China (Grant No. 200136)
文摘By taking equivalent thermal resistance, which reflects the average heat conduc- tion effect and is defined based on entransy dissipation, as optimization objective, the "volume to point" constructal problem of how to discharge the heat generated in a fixed volume to a heat sink on the border through relatively high conductive link is re-analyzed and re-optimized in this paper. The constructal shape of the control volume with the best average heat conduction effect is deduced. For the elemental area and the first order construct assembly, when the thermal current density in the high conductive link is linear with the length, the optimized shapes of assemble based on the minimization of entransy dissipation are the same as those based on minimization of maximum temperature difference, and the mean tem- perature difference is 2/3 of the maximum temperature difference. For the second and higher order construct assemblies, the thermal current densities in the high conductive link are not linear with the length, and the optimized shapes of assem- ble based on the minimization of entransy dissipation are different from those based on minimization of maximum temperature difference. For the same parame- ters, the constructs based on minimization of entransy dissipation and the con- structs based on minimization of maximum temperature difference are compared, and the results show that the constructs based on entransy dissipation can de- crease the mean temperature difference better than the constructs based on mini- mization of maximum temperature difference. But with the increase of the number of the order, the mean temperature difference does not always decrease, and there exist some fluctuations. Because the idea of entransy describes the heat transfer ability more suitably, all of the heat conduction constructal problems may be re-optimized based on it.
基金supported by grants from Department of Health of Hubei Province(No.JX5B07)Department of Health of Wuhan(No.WX09B02)
文摘The effects of granulocyte colony-stimulation-factor （G-CSF） on stem cell mobilization and its impact on the amplification of myeloid-derived suppressor cells （MDSCs） of donor mice were ex- amined. A mouse model of stem cell mobilization was established by consecutive subcutaneous injec- tion of 100 μg/kg G-CSF for 5 days. The blood from the donor mice was routinely examined during mobilization. Stem cells and MDSCs were analyzed by flow cytometry. The immunosuppressive mole- cules derived from MDSCs in serum and spleen, including hydrogen dioxide （H202） and nitric oxide （NO）, and the activity of nitric oxide synthase （NOS） were determined during the mobilization. Apop- tosis of T lymphocytes was assessed by using Annexin-V/PI. During stem cell mobilization, the number of lymphocytes and white blood cells in the peripheral blood was increased, and peaked on the 4th day. The number of stem cells in G-CSF-treated mice was significantly greater than that in controls （P〈0.01）. The expansions of MSDCs were also observed after G-CSF mobilization, with a more notable rate of growth in the peripheral blood than in the spleen. The activity of NOS and the production of NO were increased in the donor mice, and the serum H202 levels were approximately 4-fold greater than the con- trois. Consequently, apoptosis of T lymphocytes was increased and showed a positive correlation with the elevated percentage of MDSCs. It was concluded that G-CSF could provide sufficient peripheral blood stem cells for transplantation. Exogenous administration of G-CSF caused the accumulation of MDSCs in the peripheral blood and the spleen, which could lead to apoptosis ofT lymphocytes and may offer a new strategy for the prevention and treatment of graft versus host disease.
文摘In order to optimize test flow after the default flow is modified by a tester, a new software framework for the radar fault isolation is illustrated. This framework separates all mapping algorithms from test flows so as to modify flow and to insert mapping algorithm dynamically in testing process. Based on this framework, a kind of optimization method of test flow is proposed and studied. By defining an objective function, we can evaluate all candidate test flows so as to get an optimized flow. An example explains how to search the flow from candidate flows.
基金supported by the National Basic Research Program of China(973 Program)under Grant No.2012CB315800the National Natural Science Foundation of China under Grants No.61275077,No.61071117,No.61171158,No.61102131+1 种基金the Natural Science Foundation Project of CQ,CSTC under GrantsNo.2009BB2285,No.2008BB2414,No.2010BB2413,No.2010BB2409,No.2010BB2413the Projects of the Education Council of Chongqing under Grants No.KJ080513,No.KJ080522,No.KJ110519,No.KJ110527
文摘Hybrid optical switching networks make full use of the advantages of Optical Circuit Switching(OCS)and Optical Burst Switching(OBS).In parallel hybrid optical switching networks,edge nodes choose a switching mode for traffic and no longer change.The inflexible decision making of the traffic transfer mode leads to low resource utilization when the arrival rate of the OCS traffic is lower than the capacity of the light path.In this paper,a new transmission scheme is proposed to improve resource utilization for hybrid optical switching networks.When the traffic arrival rate of the light path is lower than the transmission rate of the light path,the OCS traffic flow is reshaped at the edge nodes to generate a series of voids.Then,several message packets are sent along the light path to inform the core nodes of the voids of the light paths that represent the unused bandwidth resources.To improve the resource utilization,the voids can be filled with data bursts by core nodes.The simulation results show that the new scheme can effectively reduce the burst loss rate and improve the link utilization of the hybrid optical switching network on the premise of a providing service quality guarantee for OCS traffic.
文摘The electrical properties of chemically derived graphene and graphene grown by chemical vapor deposition （CVD）, until now, have been inferior to those of mechanically exfoliated graphene. However, because graphene is easier to produce in large quantities through CVD or growth from solid carbon sources, it has a higher potential for use in future electronics applications. Generally, modifications to the pristine lattice structure of graphene tend to adversely affect the electrical properties by shifting the doping level and changing the conductivity and the mobility. Here we show that a small degree of graphene surface functionalization, using diazonium salts with electron-withdrawing and electron-donating functional groups, is sufficient to predominantly induce p-type doping, undiminished mobility, and higher conductivity at the neutrality point. Molecules without a diazonium anchor group desorb easily and do not have a significant effect on the electronic properties of graphene devices. We further demonstrate the variability between identically fabricated pristine devices, thereby underscoring the caution needed when characterizing graphene device behaviors lest conclusions be drawn based on singular extremes.
