Treatise on Cold Pathogenic Diseases is an ancient guideline for traditional Chinese medicine(TCM) clinicians which classified all diseases into six meridians.In Treatise on Cold Pathogenic Diseases, many syndromes ar...Treatise on Cold Pathogenic Diseases is an ancient guideline for traditional Chinese medicine(TCM) clinicians which classified all diseases into six meridians.In Treatise on Cold Pathogenic Diseases, many syndromes are enunciated in simple vocabularies without physiology and pathology, which is always criticized.It seems that a bridge is necessary for physiological and pathological understanding on Treatise on Cold Pathogenic Diseases.In past decade, two definition of life in cell and in our body are presented respectively.In both definitions, energy conversion is the core pathways for all organisms which can be regarded as motion of qi.Moreover, metabolism of energy agents can be seen as yang while gene expression and stem cell proliferation & differentiation(SCPD) should be seen as yin in cell and in our body respectively.The both definitions also outline the physiology and pathology of six meridians in Treatise on Cold Pathogenic Diseases, which can be unveiled as followings: taiyang meridian-elimination of energy and end metabolites;yangming meridian-acquiring energy agents;shaoyin meridian-the conversions of energy agents;taiyin meridian-new born somatic cell attending the metabolism of energy agents and then going to die;shaoyin meridian-storage and activity of stem cell;jueyin meridian-proliferation & differentiation of stem cell to produce somatic cell.These definitions will ignite new physiological and pathological understandings on Treatise on Cold Pathogenic Diseases.展开更多
Objective: To observe the effect of Yinian Jiangya Yin (Decoction for lowering blood pressure to prolong life) on patients with early hypertension and its mechanism on the function of vascular endotheliocytes. Methods...Objective: To observe the effect of Yinian Jiangya Yin (Decoction for lowering blood pressure to prolong life) on patients with early hypertension and its mechanism on the function of vascular endotheliocytes. Methods: The 79 patients with early primary hypertension belonging to the TCM syndrome of stagnation of phlegm and blood stasis in meridians and hyperactivity of the liver-yang were randomly divided into a treatment group of 40 patients treated with Yinian Jiangya Yin and a control group of 39 patients treated with Tianma Gouteng Yin (Decoction of Gastrodia and Uncaria). The changes in score of TCM syndrome and in blood pressure before and after treatment were observed in the two groups. The contents of nitrogen monoxide (NO) and endothelin (ET) in serum after treatment were determined. Results: There was a statistical difference (P<0.05) in score of TCM syndrome, effect of lowering blood pressure, and the contents of ET and NO in serum after treatment between the two groups. Conclusion: The effect of Yinian Jiangya Yin on improving TCM syndrome of patients with primary hypertension in early stage and on lowering blood pressure may be related to its regulating the imbalanced condition between ET and NO for restoring the function of endothelium-dependent vasodilation.展开更多
Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or ...Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or empirical in nature without a formal scientific foundation. Based on bipolar set theory, an equilibrium/non-equilibrium computational model of Yin-Yang Wu-Xing is proposed. The Yin-Yang Wu-Xing dynamical systems are formulated so that equilibrium and non-equilibrium conditions can be established and proved. Computer simulations of equilibrium and non-equilibrium processes show that this new approach can provide diagnostic decision support in TCM. Thus, this equilibrium-based approach provides a unique scientific basis for future research in TCM, Qi （vital energy）, QiGong, Meridians and Collaterals （acupuncture channels） and herbal treatment. On the other hand, it provides a basic Yin-Yang cellular network architecture for modem scientific research in genomics such that regulation mechanisms of the ubiquitous YY1 protein for cell processes can be explained.展开更多
Objective: To observe and compare clinical therapeutic effect of acupuncture and moxibustion at different acupoint groups in stroke patients in the convalescence stage. Methods: Sixty stroke patients were evenly rando...Objective: To observe and compare clinical therapeutic effect of acupuncture and moxibustion at different acupoint groups in stroke patients in the convalescence stage. Methods: Sixty stroke patients were evenly randomized into yin-meridian group and yang-meridian group. On the basis of the treatment with Chinese and Western medicines, these stroke patients of two groups were treated mainly by acupuncture of acupoints of yin meridians such as Jiquan (极泉HT 1), Tongli (通里HT 5), Neiguan (内关PC 6), etc., and those of yang meridians as Jianyu (NFDA1 LI 15), Quchi (曲池 LI 11), Shousanli (手三里LI 10), etc. respectively. After 30 days’ treatment, the therapeutic effect was evaluated by using American National Institutes of Health Stroke Scale (NIHSS), Hamilton Depression (HAMD) Rating Scale, Mini-Mental State Examination (MMSE), Barthel Index and Activities of Daily Living (ADL) Scale. Results: Following treatment, the therapeutic effect of yin-meridian group was significantly superior to that of yang-meridian group in improving stroke patients’ neurological deficits [Level B: 50% (15/30) vs 20% (6/30)] and ADL [Level Ⅱ: 40% (12/30) vs 13.3% (4/30)]. No significant difference was found between two groups in the neurological impairment domains. Conclusion: Acu-moxibustion of acupoints of yin meridians is superior to acupoints of yang meridians in improving stroke patients’ neurological impairment and daily living activities.展开更多
目的:探讨参芪地黄汤合桃核承气汤化裁辨治气阴亏虚、瘀浊阻络证糖尿病肾病的临床效果。方法:将本院收治的120例糖尿病肾病患者随机分为对照组和观察组患者各60例。对照组患者给予厄贝沙坦片治疗,观察组患者则加用由参芪地黄汤合桃核承...目的:探讨参芪地黄汤合桃核承气汤化裁辨治气阴亏虚、瘀浊阻络证糖尿病肾病的临床效果。方法:将本院收治的120例糖尿病肾病患者随机分为对照组和观察组患者各60例。对照组患者给予厄贝沙坦片治疗,观察组患者则加用由参芪地黄汤合桃核承气汤化裁而成的汤剂治疗,2周为1个疗程,两组均连续治疗4个疗程。治疗后比较有效率,评价中医证候积分变化,观察患者糖脂代谢、肾功能及血液流变水平变化。结果:观察组的临床治疗效果更显著,其有效率91.7%高于对照组76.7%(P<0.05);观察组患者经治疗后症状改善程度较对照组明显,其中医证候积分下降程度大于对照组患者(P<0.05);观察组的糖脂代谢、肾功能及血液流变水平改善显著优于对照组患者,其血糖FPG、2 h PG、Hb A1c及血脂TC、TG、LDL-C水平较对照组显著降低,肾功能UAER、UTP、SCr、α1-MG、β2-MG及血液流变各指标亦显著低于对照组患者(P<0.05)。结果:参芪地黄汤合桃核承气汤化裁辨治气阴亏虚、瘀浊阻络证糖尿病肾病疗效肯定,能有效改善患者的临床症状,改善糖脂代谢,提高肾功能,其机制与改善血液流变有一定的相关性,值得临床深入探究。展开更多
基金Zhejiang Provincial Natural Science Foundation of China(LY19H190004)
文摘Treatise on Cold Pathogenic Diseases is an ancient guideline for traditional Chinese medicine(TCM) clinicians which classified all diseases into six meridians.In Treatise on Cold Pathogenic Diseases, many syndromes are enunciated in simple vocabularies without physiology and pathology, which is always criticized.It seems that a bridge is necessary for physiological and pathological understanding on Treatise on Cold Pathogenic Diseases.In past decade, two definition of life in cell and in our body are presented respectively.In both definitions, energy conversion is the core pathways for all organisms which can be regarded as motion of qi.Moreover, metabolism of energy agents can be seen as yang while gene expression and stem cell proliferation & differentiation(SCPD) should be seen as yin in cell and in our body respectively.The both definitions also outline the physiology and pathology of six meridians in Treatise on Cold Pathogenic Diseases, which can be unveiled as followings: taiyang meridian-elimination of energy and end metabolites;yangming meridian-acquiring energy agents;shaoyin meridian-the conversions of energy agents;taiyin meridian-new born somatic cell attending the metabolism of energy agents and then going to die;shaoyin meridian-storage and activity of stem cell;jueyin meridian-proliferation & differentiation of stem cell to produce somatic cell.These definitions will ignite new physiological and pathological understandings on Treatise on Cold Pathogenic Diseases.
基金supported by the Macao Government Foundation for Development of Science and Technology, China (No. 105/2005/A)
文摘Objective: To observe the effect of Yinian Jiangya Yin (Decoction for lowering blood pressure to prolong life) on patients with early hypertension and its mechanism on the function of vascular endotheliocytes. Methods: The 79 patients with early primary hypertension belonging to the TCM syndrome of stagnation of phlegm and blood stasis in meridians and hyperactivity of the liver-yang were randomly divided into a treatment group of 40 patients treated with Yinian Jiangya Yin and a control group of 39 patients treated with Tianma Gouteng Yin (Decoction of Gastrodia and Uncaria). The changes in score of TCM syndrome and in blood pressure before and after treatment were observed in the two groups. The contents of nitrogen monoxide (NO) and endothelin (ET) in serum after treatment were determined. Results: There was a statistical difference (P<0.05) in score of TCM syndrome, effect of lowering blood pressure, and the contents of ET and NO in serum after treatment between the two groups. Conclusion: The effect of Yinian Jiangya Yin on improving TCM syndrome of patients with primary hypertension in early stage and on lowering blood pressure may be related to its regulating the imbalanced condition between ET and NO for restoring the function of endothelium-dependent vasodilation.
文摘Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or empirical in nature without a formal scientific foundation. Based on bipolar set theory, an equilibrium/non-equilibrium computational model of Yin-Yang Wu-Xing is proposed. The Yin-Yang Wu-Xing dynamical systems are formulated so that equilibrium and non-equilibrium conditions can be established and proved. Computer simulations of equilibrium and non-equilibrium processes show that this new approach can provide diagnostic decision support in TCM. Thus, this equilibrium-based approach provides a unique scientific basis for future research in TCM, Qi （vital energy）, QiGong, Meridians and Collaterals （acupuncture channels） and herbal treatment. On the other hand, it provides a basic Yin-Yang cellular network architecture for modem scientific research in genomics such that regulation mechanisms of the ubiquitous YY1 protein for cell processes can be explained.
文摘Objective: To observe and compare clinical therapeutic effect of acupuncture and moxibustion at different acupoint groups in stroke patients in the convalescence stage. Methods: Sixty stroke patients were evenly randomized into yin-meridian group and yang-meridian group. On the basis of the treatment with Chinese and Western medicines, these stroke patients of two groups were treated mainly by acupuncture of acupoints of yin meridians such as Jiquan (极泉HT 1), Tongli (通里HT 5), Neiguan (内关PC 6), etc., and those of yang meridians as Jianyu (NFDA1 LI 15), Quchi (曲池 LI 11), Shousanli (手三里LI 10), etc. respectively. After 30 days’ treatment, the therapeutic effect was evaluated by using American National Institutes of Health Stroke Scale (NIHSS), Hamilton Depression (HAMD) Rating Scale, Mini-Mental State Examination (MMSE), Barthel Index and Activities of Daily Living (ADL) Scale. Results: Following treatment, the therapeutic effect of yin-meridian group was significantly superior to that of yang-meridian group in improving stroke patients’ neurological deficits [Level B: 50% (15/30) vs 20% (6/30)] and ADL [Level Ⅱ: 40% (12/30) vs 13.3% (4/30)]. No significant difference was found between two groups in the neurological impairment domains. Conclusion: Acu-moxibustion of acupoints of yin meridians is superior to acupoints of yang meridians in improving stroke patients’ neurological impairment and daily living activities.
文摘目的:探讨参芪地黄汤合桃核承气汤化裁辨治气阴亏虚、瘀浊阻络证糖尿病肾病的临床效果。方法:将本院收治的120例糖尿病肾病患者随机分为对照组和观察组患者各60例。对照组患者给予厄贝沙坦片治疗,观察组患者则加用由参芪地黄汤合桃核承气汤化裁而成的汤剂治疗,2周为1个疗程,两组均连续治疗4个疗程。治疗后比较有效率,评价中医证候积分变化,观察患者糖脂代谢、肾功能及血液流变水平变化。结果:观察组的临床治疗效果更显著,其有效率91.7%高于对照组76.7%(P<0.05);观察组患者经治疗后症状改善程度较对照组明显,其中医证候积分下降程度大于对照组患者(P<0.05);观察组的糖脂代谢、肾功能及血液流变水平改善显著优于对照组患者,其血糖FPG、2 h PG、Hb A1c及血脂TC、TG、LDL-C水平较对照组显著降低,肾功能UAER、UTP、SCr、α1-MG、β2-MG及血液流变各指标亦显著低于对照组患者(P<0.05)。结果:参芪地黄汤合桃核承气汤化裁辨治气阴亏虚、瘀浊阻络证糖尿病肾病疗效肯定,能有效改善患者的临床症状,改善糖脂代谢,提高肾功能,其机制与改善血液流变有一定的相关性,值得临床深入探究。
