Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is c...Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is complex and inconclusive in the point of view of western medicine, which is the fundamental reason for the lack of drugs that can reverse the course of the disease. People have gradually shifted from simple amyloid hypothesis to new pathogenesis theories, such as gamma oscillation, prion like transmission, and so on. As an effective means to treat AD, traditional Chinese medicine has made some research progress in recent years. This article mainly reviews the etiology, pathogenesis and treatment of AD, so as to provide reference for the prevention and treatment of AD. Methods: Through systematic literature research, comparison and analysis, the main pathogenesis, influencing factors, progress and development tendency of traditional Chinese medicine and Western medicine in the treatment of AD are presented. Results: Alzheimer’s disease is a kind of multiple neurodegenerative diseases. The pathogenesis and related targets of AD still need to be further explored. The main pathological phenomenon of AD is senile plaques formed by intracellular neurofibrillary tangles and extracellular amyloid protein aggregation. Existing possible pathogenesis includes β-amyloid cascade hypothesis, tau protein hypothesis, cholinergic hypothesis and so on. As the pathogenesis of AD has not been clarified, so far no effective therapeutic drugs or means have been found. The traditional drugs used to treat AD mainly include acetylcholinesterase inhibitor kabbalatin, galantamine, donepezil, and N-methyl-D-aspartate receptor antagonist memantine. However, although these marketed drugs can slow down the course of the disease and alleviate symptoms, they cannot totally cure the disease. Traditional Chinese medicine has the characteristics of personalized differentiation and treatment. The Western medicine can accurately deter展开更多
Chinese medicine （CM） basic theory differs substantially from modernmedicine in methodology. CM views the healthy human body as an entity in yin-yang equilibrium. CM practitioners typically diagnose patients with ＂...Chinese medicine （CM） basic theory differs substantially from modernmedicine in methodology. CM views the healthy human body as an entity in yin-yang equilibrium. CM practitioners typically diagnose patients with ＂Zheng （CMsyndrome）＂-yin-yang status of specific organs, and the ultimate goal of treatment inCM is to restore the yin-yang balance. This concept might seem strange to Westernperceptions; however, CM philosophy and methodology have been graduallyaccepted and used in the West. There is growing evidence from prestigiousworldwide journals like Nature, Science and Cell indicating that CM theory isbecoming an important component in dealing with health issues in the West.展开更多
目的:观察中医治疗糖尿病的疗效。方法:分析本院自2011年1月-2013年1月收治的糖尿病患者125例,按随机数字表法分为对照组61例给予西医常规降糖药物治疗,观察组64例给予桃红四物汤加减与西医常规降糖治疗。比较两组患者血糖血脂的变化情...目的:观察中医治疗糖尿病的疗效。方法:分析本院自2011年1月-2013年1月收治的糖尿病患者125例,按随机数字表法分为对照组61例给予西医常规降糖药物治疗,观察组64例给予桃红四物汤加减与西医常规降糖治疗。比较两组患者血糖血脂的变化情况,包括FPG(空腹血糖)、TC(血清总胆固醇)、TG(血清甘油三酯)、2 h PG(餐后两小时血糖)、HbAlc(糖化血红蛋白);以及两组临床症状改善情况,包括乏力、消瘦、口干、失眠、泌汗异常、夜尿频多。结果:(1)治疗后两组FPG、TC、TG、2 h PG,HbAlc水平比治疗前均显著降低,差异有统计学意义(P<0.05)。治疗后观察组FPG、TC、TG、2 h PG、HbAlc水平显著低于对照组,差异有统计学意义(P<0.05);(2)观察组治疗后乏力、消瘦、口干、失眠、泌汗异常、夜尿频多发生率均显著低于对照组,差异有统计学意义(P<0.05)。结论:中医与西医常规疗法联合治疗糖尿病疗效确切,表明中医治疗糖尿病具有一定的应用价值。展开更多
文摘Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is complex and inconclusive in the point of view of western medicine, which is the fundamental reason for the lack of drugs that can reverse the course of the disease. People have gradually shifted from simple amyloid hypothesis to new pathogenesis theories, such as gamma oscillation, prion like transmission, and so on. As an effective means to treat AD, traditional Chinese medicine has made some research progress in recent years. This article mainly reviews the etiology, pathogenesis and treatment of AD, so as to provide reference for the prevention and treatment of AD. Methods: Through systematic literature research, comparison and analysis, the main pathogenesis, influencing factors, progress and development tendency of traditional Chinese medicine and Western medicine in the treatment of AD are presented. Results: Alzheimer’s disease is a kind of multiple neurodegenerative diseases. The pathogenesis and related targets of AD still need to be further explored. The main pathological phenomenon of AD is senile plaques formed by intracellular neurofibrillary tangles and extracellular amyloid protein aggregation. Existing possible pathogenesis includes β-amyloid cascade hypothesis, tau protein hypothesis, cholinergic hypothesis and so on. As the pathogenesis of AD has not been clarified, so far no effective therapeutic drugs or means have been found. The traditional drugs used to treat AD mainly include acetylcholinesterase inhibitor kabbalatin, galantamine, donepezil, and N-methyl-D-aspartate receptor antagonist memantine. However, although these marketed drugs can slow down the course of the disease and alleviate symptoms, they cannot totally cure the disease. Traditional Chinese medicine has the characteristics of personalized differentiation and treatment. The Western medicine can accurately deter
基金Partly supported by CTSI-KL2 award to Wang ZX(RR025760) from National Institutes of Health(NIH)/National Center for Research Resources(NCRR)-Indiana ClinicalTranslational Sciences Institute(ICTSI)-K12 Program(A.Shekhar)
文摘Chinese medicine （CM） basic theory differs substantially from modernmedicine in methodology. CM views the healthy human body as an entity in yin-yang equilibrium. CM practitioners typically diagnose patients with ＂Zheng （CMsyndrome）＂-yin-yang status of specific organs, and the ultimate goal of treatment inCM is to restore the yin-yang balance. This concept might seem strange to Westernperceptions; however, CM philosophy and methodology have been graduallyaccepted and used in the West. There is growing evidence from prestigiousworldwide journals like Nature, Science and Cell indicating that CM theory isbecoming an important component in dealing with health issues in the West.
文摘目的:观察中医治疗糖尿病的疗效。方法:分析本院自2011年1月-2013年1月收治的糖尿病患者125例,按随机数字表法分为对照组61例给予西医常规降糖药物治疗,观察组64例给予桃红四物汤加减与西医常规降糖治疗。比较两组患者血糖血脂的变化情况,包括FPG(空腹血糖)、TC(血清总胆固醇)、TG(血清甘油三酯)、2 h PG(餐后两小时血糖)、HbAlc(糖化血红蛋白);以及两组临床症状改善情况,包括乏力、消瘦、口干、失眠、泌汗异常、夜尿频多。结果:(1)治疗后两组FPG、TC、TG、2 h PG,HbAlc水平比治疗前均显著降低,差异有统计学意义(P<0.05)。治疗后观察组FPG、TC、TG、2 h PG、HbAlc水平显著低于对照组,差异有统计学意义(P<0.05);(2)观察组治疗后乏力、消瘦、口干、失眠、泌汗异常、夜尿频多发生率均显著低于对照组,差异有统计学意义(P<0.05)。结论:中医与西医常规疗法联合治疗糖尿病疗效确切,表明中医治疗糖尿病具有一定的应用价值。
