With the rapid development of smart products,fexible and stretchable smart wearable electronic devices gradually play an important role,and they are considered as the pioneers of the new generation of fexible electron...With the rapid development of smart products,fexible and stretchable smart wearable electronic devices gradually play an important role,and they are considered as the pioneers of the new generation of fexible electronic devices.Among these intelligent devices,fexible and stretchable strain sensors have been widely studied for their good fexibility,high sensitivity,high repeatability and huge potential for application in personal healthcare and motion detection.Moreover,unlike traditional rigid bulky sensors,the high-performance fexible strain sensors are lightweight portable devices with excellent mechanical and electrical performance,which can meet personalized needs and become more popular.Herein,the research progress of fexible strain sensors in recent years are reviewed,which mainly introducing the sensing principles and key parameters of strain sensors,commonly used conductive materials and fexible substrates and common preparation methods,and fnally proposes the future application and prospects of strain sensors.展开更多
Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators.Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in bio...Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators.Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects.Current semi-implantable devices are mainly based on single-parameter detection.Miniaturized semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode sensitivity.This study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)concentrations.The electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric sensing.The MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above ions.In vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex environments.This work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.展开更多
Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic wounds.Therefore,achieving real-time de...Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic wounds.Therefore,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing process.Recently,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive manner.They provide more precise and continuous monitoring data,making them as emerging tools for clinical diagnostics.In this review,we first discuss the species and community distribution of different types of bacteria in chronic wounds.Next,we introduce currently developed techniques for detecting bacteria at wound sites.Fol-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound sites.We believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.展开更多
基金Financial support of this work was provided by Natural Science Foundation of Shandong Province of China(ZR2018QEM004,ZR2020QE081)Shandong Province Key Research and Development Plan(Major scientifc and technological innovation projects)(2019JZZY010340,2019JZZY010335,2019GGX102022)China Postdoctoral Science Foundation via grant No.2020M671994.
文摘With the rapid development of smart products,fexible and stretchable smart wearable electronic devices gradually play an important role,and they are considered as the pioneers of the new generation of fexible electronic devices.Among these intelligent devices,fexible and stretchable strain sensors have been widely studied for their good fexibility,high sensitivity,high repeatability and huge potential for application in personal healthcare and motion detection.Moreover,unlike traditional rigid bulky sensors,the high-performance fexible strain sensors are lightweight portable devices with excellent mechanical and electrical performance,which can meet personalized needs and become more popular.Herein,the research progress of fexible strain sensors in recent years are reviewed,which mainly introducing the sensing principles and key parameters of strain sensors,commonly used conductive materials and fexible substrates and common preparation methods,and fnally proposes the future application and prospects of strain sensors.
基金国家重点基础研究发展(973)计划(2010CB732606)Hong Kong Innovation and Technology Fund supported by Standard Telecommunication Ltd.+3 种基金Jetfly Technology Ltd.Golder Meditch Company Ltd.Bird International Ltd.Bright Steps Corportation and PCCW
基金The authors would like to acknowledge financial support from the National Key R&D Program of China(Nos.2021YFF1200700 and 2021YFA0911100)the National Natural Science Foundation of China(Nos.T2225010,32171399,and 32171456)+4 种基金the Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(No.22dfx02)Pazhou Lab,Guangzhou(No.PZL2021KF0003)The authors also would like to thank the funding support from the Opening Project of Key Laboratory of Microelectronic Devices&Integrated Technology,Institute of Microelectronics,Chinese Academy of Sciences,and State Key Laboratory of Precision Measuring Technology and Instruments(No.pilab2211)QQOY would like to thank the China Postdoctoral Science Foundation(No.2022M713645)JL would like to thank the National Natural Science Foundation of China(No.62105380)and the China Postdoctoral Science Foundation(No.2021M693686).
文摘Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators.Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects.Current semi-implantable devices are mainly based on single-parameter detection.Miniaturized semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode sensitivity.This study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)concentrations.The electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric sensing.The MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above ions.In vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex environments.This work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.
基金supported by the National Natural Science Foundation of China(22205260,82172211,92268206)National Key Research and Development Programs of China(2022YFA1104303)+1 种基金the CAMS Innova-tion Fund for Medical Sciences(CIFMS,2019-I2M-5-059)the Military Medical Research Projects(145AKJ260015000X,2022-JCJQ-ZB-09600,2023-JSKY-SSQG-006).
文摘Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic wounds.Therefore,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing process.Recently,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive manner.They provide more precise and continuous monitoring data,making them as emerging tools for clinical diagnostics.In this review,we first discuss the species and community distribution of different types of bacteria in chronic wounds.Next,we introduce currently developed techniques for detecting bacteria at wound sites.Fol-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound sites.We believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.
