The prevalence of type 2 diabetes mellitus(T2DM)is increasing rapidly worldwide.Because of the limited success of generic interventions,the focus of the disease study has shifted toward personalized strategies,particu...The prevalence of type 2 diabetes mellitus(T2DM)is increasing rapidly worldwide.Because of the limited success of generic interventions,the focus of the disease study has shifted toward personalized strategies,particularly in the early stages of the disease.Traditional Chinese medicine(TCM)is based on a systems view combined with personalized strategies and has improved our knowledge of personalized diagnostics.From a systems biology perspective,the understanding of personalized diagnostics can be improved to yield a biochemical basis for such strategies;for example,metabolomics can be used in combination with other system-based diagnostic methods such as ultra-weak photon emission(UPE).In this study,we investigated the feasibility of using plasma metabolomics obtained from 44 pre-T2DM subjects to stratify the following TCM-based subtypes:Qi-Yin deficiency,Qi-Yin deficiency with dampness,and Qi-Yin deficiency with stagnation.We studied the relationship between plasma metabolomics and UPE with respect to TCM-based subtyping in order to obtain biochemical information for further interpreting disease subtypes.Principal component analysis of plasma metabolites revealed differences among the TCM-based pre-T2DM subtypes.Relatively high levels of lipids(e.g.,cholesterol esters and triglycerides)were important discriminators of two of the three subtypes and may be associated with a higher risk of cardiovascular disease.Plasma metabolomics data indicate that the lipid profile is an essential component captured by UPE with respect to stratifying subtypes of T2DM.The results suggest that metabolic differences exist among different TCM-based subtypes of pre-T2DM,and profiling plasma metabolites can be used to discriminate among these subtypes.Plasma metabolomics thus provides biochemical insights into system-based UPE measurements.展开更多
目的分析不同亚型难治性胃食管反流病(rGERD)患者的心理状态。方法选择2017年1月至2019年10月在安徽医科大学附属省立医院消化内科门诊就诊的182例rGERD患者,均行24 h pH-阻抗监测,根据临床表现与病理学检查结果分为反流性食管炎组(RE组...目的分析不同亚型难治性胃食管反流病(rGERD)患者的心理状态。方法选择2017年1月至2019年10月在安徽医科大学附属省立医院消化内科门诊就诊的182例rGERD患者,均行24 h pH-阻抗监测,根据临床表现与病理学检查结果分为反流性食管炎组(RE组,n=54)、非糜烂性反流病组(NERD组,n=108)和Barrett食管组(BE组,n=20),利用汉密尔顿焦虑量表(HAMA)与汉密尔顿抑郁量表(HAMD)评估患者的心理状态,应用GERD专用生活质量(GERD-HRQL)量表对3组患者的生活质量进行评价。结果 3组患者HAMA、HAMD评分的差异有统计学意义(P<0.05),且NERD组患者HAMA和HAMD评分高于RE组,差异有统计学意义(P<0.05)。NERD组患者弱酸反流发生率高于RE组、BE组,差异均有统计学意义(P<0.0167)。结论 NERD患者比RE、BE患者更易发生弱酸反流,更易出现焦虑、抑郁症状,可能是rGERD的发病机制之一。展开更多
文摘The prevalence of type 2 diabetes mellitus(T2DM)is increasing rapidly worldwide.Because of the limited success of generic interventions,the focus of the disease study has shifted toward personalized strategies,particularly in the early stages of the disease.Traditional Chinese medicine(TCM)is based on a systems view combined with personalized strategies and has improved our knowledge of personalized diagnostics.From a systems biology perspective,the understanding of personalized diagnostics can be improved to yield a biochemical basis for such strategies;for example,metabolomics can be used in combination with other system-based diagnostic methods such as ultra-weak photon emission(UPE).In this study,we investigated the feasibility of using plasma metabolomics obtained from 44 pre-T2DM subjects to stratify the following TCM-based subtypes:Qi-Yin deficiency,Qi-Yin deficiency with dampness,and Qi-Yin deficiency with stagnation.We studied the relationship between plasma metabolomics and UPE with respect to TCM-based subtyping in order to obtain biochemical information for further interpreting disease subtypes.Principal component analysis of plasma metabolites revealed differences among the TCM-based pre-T2DM subtypes.Relatively high levels of lipids(e.g.,cholesterol esters and triglycerides)were important discriminators of two of the three subtypes and may be associated with a higher risk of cardiovascular disease.Plasma metabolomics data indicate that the lipid profile is an essential component captured by UPE with respect to stratifying subtypes of T2DM.The results suggest that metabolic differences exist among different TCM-based subtypes of pre-T2DM,and profiling plasma metabolites can be used to discriminate among these subtypes.Plasma metabolomics thus provides biochemical insights into system-based UPE measurements.
文摘目的分析不同亚型难治性胃食管反流病(rGERD)患者的心理状态。方法选择2017年1月至2019年10月在安徽医科大学附属省立医院消化内科门诊就诊的182例rGERD患者,均行24 h pH-阻抗监测,根据临床表现与病理学检查结果分为反流性食管炎组(RE组,n=54)、非糜烂性反流病组(NERD组,n=108)和Barrett食管组(BE组,n=20),利用汉密尔顿焦虑量表(HAMA)与汉密尔顿抑郁量表(HAMD)评估患者的心理状态,应用GERD专用生活质量(GERD-HRQL)量表对3组患者的生活质量进行评价。结果 3组患者HAMA、HAMD评分的差异有统计学意义(P<0.05),且NERD组患者HAMA和HAMD评分高于RE组,差异有统计学意义(P<0.05)。NERD组患者弱酸反流发生率高于RE组、BE组,差异均有统计学意义(P<0.0167)。结论 NERD患者比RE、BE患者更易发生弱酸反流,更易出现焦虑、抑郁症状,可能是rGERD的发病机制之一。
