Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve ...Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve the penetration depth for bioimaging.However,the design of red persistent RTP materials is still challenging.In this study,a fused-ring structure has been proposed to effectively decrease the triplet energy level,thus extending the emission wavelength of phosphorescence.In addition,the fused-ring structure exhibits a high molar extinction coefficient(ɛ)and high luminescence efficiency due to the rigid structure.A new class of crystalline hosts(iminodibenzyl,IDB)are developed to stabilize the triplet excitons that are generated from the fused-ring molecules.The maximum RTP wavelength of doping materials can reach 635 nm with a lifetime of 9.35 ms.Water-disperse nanoparticles are successfully prepared for in vivo time-resolved bioimaging,which eliminates the background fluorescence interference from biological tissues.These reveal a delicate design strategy for the construction of long-wavelength emissive RTP materials for high-resolution bioimaging.展开更多
中国丽江积分视场光纤光谱仪(China Lijiang Integral Field Unit,简称CHILI)是中国第一台用于夜天文观测的科学级积分视场光纤光谱仪,安装在丽江天文观测站2.4 m光学望远镜上。CHILI运输到中国前,在美国德克萨斯大学奥斯汀分校(Univers...中国丽江积分视场光纤光谱仪(China Lijiang Integral Field Unit,简称CHILI)是中国第一台用于夜天文观测的科学级积分视场光纤光谱仪,安装在丽江天文观测站2.4 m光学望远镜上。CHILI运输到中国前,在美国德克萨斯大学奥斯汀分校(University of Texas at Austin)进行了实验室测试。本次实验主要针对CHILI的蓝端,主要测试内容有本底、平场、暗场和波长定标。为了明确知道谱线在像素位置上的精准波长和CHILI探测器的分辨能力,对测试数据进行了波长定标和光谱分辨能力的计算。结果显示,CHILI蓝端的波长范围约为3 500～5 300,在此波长范围内,光谱分辨本领FW H M■5,其对应的光谱分辨率R=λ/?λ约为600～1 000,符合CHILI预期要求。展开更多
The signal processing technology based on material with negative refractive index provides researchers with the latest ideas. As a new nondestructive bio-photonic technology, photoacoustic tomography is a kind of ...The signal processing technology based on material with negative refractive index provides researchers with the latest ideas. As a new nondestructive bio-photonic technology, photoacoustic tomography is a kind of imaging method based on the differences of optical absorption within the biological organization However, photoacoustic tomography by the scanning sensor or by the sensors array at present has its inherent disadvantages that may lead to poor real-time performance and high cost in the imaging process. The characteristics of acoustic lens with negative refractive index such as focusing, filtering and directional control on acoustic wave, are very suitable for solving the problem in photoacoustic tomography. With an analysis on the nega-tive quality response of acoustic lens and the advantages of negative refractive imaging, we proposed an approach using the lens to change the current photoacoustic imaging methods. The experiment showed that the imaging effectiveness of photoacoustic tomography by the designed lens is very impressive that the pressure distribution of the absorber is basically consistent with the image of the absorber. In addition, the result of 0. 6 times wavelength in the experimental image is demonstrated on sub-wave-length photoacoustic imaging through the lens designed in this work.展开更多
基金the National Natural Scientific Foundation of China(Grant Nos.22222501,21975021,21975020,21875019,22105019,and 22175023)supported by Beijing National Laboratory for Molecular Sciences(BNLMS202007)the BIT Research and Innovation Promoting Project(2022YCXZ035).
文摘Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve the penetration depth for bioimaging.However,the design of red persistent RTP materials is still challenging.In this study,a fused-ring structure has been proposed to effectively decrease the triplet energy level,thus extending the emission wavelength of phosphorescence.In addition,the fused-ring structure exhibits a high molar extinction coefficient(ɛ)and high luminescence efficiency due to the rigid structure.A new class of crystalline hosts(iminodibenzyl,IDB)are developed to stabilize the triplet excitons that are generated from the fused-ring molecules.The maximum RTP wavelength of doping materials can reach 635 nm with a lifetime of 9.35 ms.Water-disperse nanoparticles are successfully prepared for in vivo time-resolved bioimaging,which eliminates the background fluorescence interference from biological tissues.These reveal a delicate design strategy for the construction of long-wavelength emissive RTP materials for high-resolution bioimaging.
文摘中国丽江积分视场光纤光谱仪(China Lijiang Integral Field Unit,简称CHILI)是中国第一台用于夜天文观测的科学级积分视场光纤光谱仪,安装在丽江天文观测站2.4 m光学望远镜上。CHILI运输到中国前,在美国德克萨斯大学奥斯汀分校(University of Texas at Austin)进行了实验室测试。本次实验主要针对CHILI的蓝端,主要测试内容有本底、平场、暗场和波长定标。为了明确知道谱线在像素位置上的精准波长和CHILI探测器的分辨能力,对测试数据进行了波长定标和光谱分辨能力的计算。结果显示,CHILI蓝端的波长范围约为3 500～5 300,在此波长范围内,光谱分辨本领FW H M■5,其对应的光谱分辨率R=λ/?λ约为600～1 000,符合CHILI预期要求。
基金National Natural Science Foundation of China(No.61671414,No.61302159)
文摘The signal processing technology based on material with negative refractive index provides researchers with the latest ideas. As a new nondestructive bio-photonic technology, photoacoustic tomography is a kind of imaging method based on the differences of optical absorption within the biological organization However, photoacoustic tomography by the scanning sensor or by the sensors array at present has its inherent disadvantages that may lead to poor real-time performance and high cost in the imaging process. The characteristics of acoustic lens with negative refractive index such as focusing, filtering and directional control on acoustic wave, are very suitable for solving the problem in photoacoustic tomography. With an analysis on the nega-tive quality response of acoustic lens and the advantages of negative refractive imaging, we proposed an approach using the lens to change the current photoacoustic imaging methods. The experiment showed that the imaging effectiveness of photoacoustic tomography by the designed lens is very impressive that the pressure distribution of the absorber is basically consistent with the image of the absorber. In addition, the result of 0. 6 times wavelength in the experimental image is demonstrated on sub-wave-length photoacoustic imaging through the lens designed in this work.
