Acute lung injury/acute respiratory distress syndrome （ALI/ARDS）, which manifests as non-cardiogcnic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or ind...Acute lung injury/acute respiratory distress syndrome （ALI/ARDS）, which manifests as non-cardiogcnic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies.展开更多
目的用分子流行病学方法研究呼吸机相关性肺炎（vcntilator associated pneumonia ,VAP）各种感染途径在其发病机制中的作用。方法采集ICU置入人工气道行机械通气的患者下呼吸道标本、口咽分泌物、气囊上滞留物、胃液、呼吸机机管路标...目的用分子流行病学方法研究呼吸机相关性肺炎（vcntilator associated pneumonia ,VAP）各种感染途径在其发病机制中的作用。方法采集ICU置入人工气道行机械通气的患者下呼吸道标本、口咽分泌物、气囊上滞留物、胃液、呼吸机机管路标本、空气标书。从护理人员手上采集标本进行细菌培养和表型分析：再通过脉冲场凝胶电泳（pulse field gel electrophoresis，PFGE）办法分析所分离菌株是否具有同源性。结果48例患者中22例发生VAP，其下呼吸道标本细菌培养17例阳性，以G-性菌为主，其中铜绿假单胞菌居首位。且为多重耐药菌；对9例患者来源菌株行PFGE分析．6例气囊上滞留物分离菌株与相应下呼吸道分离菌株为同一PFGE型，5例胃液分离菌株与相应下呼吸道分离菌株为H—PFGE型，3例呼吸机管路样品分离菌株与相应下呼吸道分离菌株为同一PFGE型．2例口咽部分泌物分离菌株与相应下呼吸道分离菌株为同-PFGE型。结论VAP患者下呼吸道病原体与气囊上滞留物、胃液分离菌有很高的同源性．在感染源的防治上应列为重中之重。展开更多
文摘Acute lung injury/acute respiratory distress syndrome （ALI/ARDS）, which manifests as non-cardiogcnic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies.
文摘目的用分子流行病学方法研究呼吸机相关性肺炎（vcntilator associated pneumonia ,VAP）各种感染途径在其发病机制中的作用。方法采集ICU置入人工气道行机械通气的患者下呼吸道标本、口咽分泌物、气囊上滞留物、胃液、呼吸机机管路标本、空气标书。从护理人员手上采集标本进行细菌培养和表型分析：再通过脉冲场凝胶电泳（pulse field gel electrophoresis，PFGE）办法分析所分离菌株是否具有同源性。结果48例患者中22例发生VAP，其下呼吸道标本细菌培养17例阳性，以G-性菌为主，其中铜绿假单胞菌居首位。且为多重耐药菌；对9例患者来源菌株行PFGE分析．6例气囊上滞留物分离菌株与相应下呼吸道分离菌株为同一PFGE型，5例胃液分离菌株与相应下呼吸道分离菌株为H—PFGE型，3例呼吸机管路样品分离菌株与相应下呼吸道分离菌株为同一PFGE型．2例口咽部分泌物分离菌株与相应下呼吸道分离菌株为同-PFGE型。结论VAP患者下呼吸道病原体与气囊上滞留物、胃液分离菌有很高的同源性．在感染源的防治上应列为重中之重。
