目的探讨以新产程标准为指导处理产程对分娩结局的影响。方法以2015年1—8月于中山大学附属第三医院实施新产程标准的709例初产妇为研究组,以2014年1—8月本院实施传统产程标准的819例初产妇为对照组,比较两组分娩方式、产后出血发生率...目的探讨以新产程标准为指导处理产程对分娩结局的影响。方法以2015年1—8月于中山大学附属第三医院实施新产程标准的709例初产妇为研究组,以2014年1—8月本院实施传统产程标准的819例初产妇为对照组,比较两组分娩方式、产后出血发生率、新生儿不良结局(Apgar评分异常、脐动脉血气p H值<7.0、羊水粪染)发生率、产程时间;观察研究组中传统产程标准诊断为产程曲线异常初产妇的分娩结局。结果研究组自然分娩率高于对照组,剖宫产率低于对照组(P<0.01);两组产妇产后出血发生率、1 min Apgar评分异常发生率、脐动脉血气pH值<7.0发生率、羊水粪染发生率比较,差异无统计学意义(P>0.05);两组5 min Apgar评分均无异常;研究组第一产程、第二产程、总产程时间长于对照组(P<0.05)。研究组中按传统产程标准诊断为潜伏期延长(>16 h)、活跃期延长(>8 h)、第二产程延长(>2 h)的初产妇自然分娩率分别为45.8%(11/24)、69.2%(9/13)、84.1%(37/44)。结论以新产程标准为指导处理产程,能降低剖宫产率,促进自然分娩,不增加产后出血、产钳助产、新生儿不良结局等风险。展开更多
Background：In the mainland of China, the trial of labor after cesarean section is still a relatively new technique. In this study, we aimed to investigate the effects of labor onset, oxytocin use, and epidural anesth...Background：In the mainland of China, the trial of labor after cesarean section is still a relatively new technique. In this study, we aimed to investigate the effects of labor onset, oxytocin use, and epidural anesthesia on maternal and neonatal outcomes for vaginal birth after cesarean section （VBAC） in a tertiary hospital in China.Methods：This was a retrospective study carried out on 212 VBAC cases between January 2015 and June 2017 in Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Relevant data were acquired on a form, including maternal age, gravidity and parity, body mass index before pregnancy, weight gain during pregnancy, type of labor onset, gestational age, the use of oxytocin and epidural anesthesia, birth mode, the duration of labor, and neonatal weight. The factors affecting maternal and neonatal outcomes for cases involving VBAC, especially with regards to postpartum hemorrhage （PPH） and fetal distress, were evaluated by univariate analysis and multivariable logistic regression.Results：Data showed that 36 women （17.0%） had postpartum hemorrhage （PPH） and 51 cases （24.1%） featured fetal distress. Normal delivery took place for 163 infants （76.9%） while 49 infants （23.1%） underwent operative vaginal deliveries with forceps. There were 178 cases （84.0%） of spontaneous labor and 34 cases （16.0%） required induction. Oxytocin was used in 54 cases （25.5%） to strengthen uterine contraction, and 65 cases （30.7%） received epidural anesthesia. The rate of normal delivery in cases involving PPH was significantly lower than those without PPH （61.1% vs. 80.1%; χ2 = 6.07, P = 0.01）. Multivariate logistic analysis showed that the intrapartum administration of oxytocin （odds ratio [OR] = 2.47; 95% confidence interval [CI] = 1.07–5.74; P = 0.04） and birth mode （OR = 0.40; 95% CI = 0.18–0.87; P = 0.02） was significantly associated with PPH in VBAC cases. Operative vaginal delivery occurred more frequently in the group with feta展开更多
Background Vaginal intraepithelial neoplasia （VAIN）, as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chine...Background Vaginal intraepithelial neoplasia （VAIN）, as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population. Methods A case-control study was conducted, including 63 VAIN cases and 64healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus （HPV） status. Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women （95% CI： 1.10-3.85; P=-0.024）. The patients with previous hysterectomy had an increased risk of VAIN （OR=4.69; P=0.003）. Patients with a history of cervical cancer or CIN were predisposed to VAIN （OR=78.75; P 〈0.0001）. The rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load （OR=126.00; P=0.000）. Multivariate analysis showed that HPV infection and a history of CIN or cervical cancer were still found to be significant in patients. Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN.展开更多
Objective To evaluate the possibility of vaginal hysterectomy for patients with moderately enlarged uterus of benign lesions. Methods One hundred and seventeen women with benign uterine diseases underwent vaginal hyst...Objective To evaluate the possibility of vaginal hysterectomy for patients with moderately enlarged uterus of benign lesions. Methods One hundred and seventeen women with benign uterine diseases underwent vaginal hysterectomy. These patients were divided into two groups according to uterine weight. Group Ⅰ contained 60 patients with uterine enlargement to a weight of 200 to 750 g, and group Ⅱ contained 57 patients with uterine weight of less than 200 g. Uterine morcellation was performed in some cases. The peri-operative data in both groups were analyzed. Results In group Ⅰ, 59 cases underwent transvaginal hysterectomy successfully, except 1 case con-verted to abdominal operation and the uterine morcellation was performed in 21 women. In group Ⅱ, all patients successfully underwent transvaginal hysterectomy without any assistance of special technique. The mean uterine weight of group Ⅰ was significantly heavier than that of group Ⅱ(280.18 ± 100.40 g vs 146.48 ± 35.19 g). The mean operating time was significantly longer for group Ⅰ than that for group Ⅱ(83.93 ± 26.26 minutes vs 35.22 ± 20.55 minutes). There were no significant differences in blood loss and complications between groupⅠ and group Ⅱ. There was no injury of urinary bladder or rectum, and no vaginal vault infection. Conclusions Vaginal hysterectomy of moderately enlarged uterus can be safely and effectively performed by experienced operators. In some cases, in order to reduce the uterine volume, uterine mor-cellation should be used to shorten operative time, reduce the bleeding, and lower the postoperative complications.展开更多
文摘目的探讨以新产程标准为指导处理产程对分娩结局的影响。方法以2015年1—8月于中山大学附属第三医院实施新产程标准的709例初产妇为研究组,以2014年1—8月本院实施传统产程标准的819例初产妇为对照组,比较两组分娩方式、产后出血发生率、新生儿不良结局(Apgar评分异常、脐动脉血气p H值<7.0、羊水粪染)发生率、产程时间;观察研究组中传统产程标准诊断为产程曲线异常初产妇的分娩结局。结果研究组自然分娩率高于对照组,剖宫产率低于对照组(P<0.01);两组产妇产后出血发生率、1 min Apgar评分异常发生率、脐动脉血气pH值<7.0发生率、羊水粪染发生率比较,差异无统计学意义(P>0.05);两组5 min Apgar评分均无异常;研究组第一产程、第二产程、总产程时间长于对照组(P<0.05)。研究组中按传统产程标准诊断为潜伏期延长(>16 h)、活跃期延长(>8 h)、第二产程延长(>2 h)的初产妇自然分娩率分别为45.8%(11/24)、69.2%(9/13)、84.1%(37/44)。结论以新产程标准为指导处理产程,能降低剖宫产率,促进自然分娩,不增加产后出血、产钳助产、新生儿不良结局等风险。
文摘Background：In the mainland of China, the trial of labor after cesarean section is still a relatively new technique. In this study, we aimed to investigate the effects of labor onset, oxytocin use, and epidural anesthesia on maternal and neonatal outcomes for vaginal birth after cesarean section （VBAC） in a tertiary hospital in China.Methods：This was a retrospective study carried out on 212 VBAC cases between January 2015 and June 2017 in Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Relevant data were acquired on a form, including maternal age, gravidity and parity, body mass index before pregnancy, weight gain during pregnancy, type of labor onset, gestational age, the use of oxytocin and epidural anesthesia, birth mode, the duration of labor, and neonatal weight. The factors affecting maternal and neonatal outcomes for cases involving VBAC, especially with regards to postpartum hemorrhage （PPH） and fetal distress, were evaluated by univariate analysis and multivariable logistic regression.Results：Data showed that 36 women （17.0%） had postpartum hemorrhage （PPH） and 51 cases （24.1%） featured fetal distress. Normal delivery took place for 163 infants （76.9%） while 49 infants （23.1%） underwent operative vaginal deliveries with forceps. There were 178 cases （84.0%） of spontaneous labor and 34 cases （16.0%） required induction. Oxytocin was used in 54 cases （25.5%） to strengthen uterine contraction, and 65 cases （30.7%） received epidural anesthesia. The rate of normal delivery in cases involving PPH was significantly lower than those without PPH （61.1% vs. 80.1%; χ2 = 6.07, P = 0.01）. Multivariate logistic analysis showed that the intrapartum administration of oxytocin （odds ratio [OR] = 2.47; 95% confidence interval [CI] = 1.07–5.74; P = 0.04） and birth mode （OR = 0.40; 95% CI = 0.18–0.87; P = 0.02） was significantly associated with PPH in VBAC cases. Operative vaginal delivery occurred more frequently in the group with feta
基金the grants from the National Natural Science Foundation of China，Beijing Nova Program
文摘Background Vaginal intraepithelial neoplasia （VAIN）, as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population. Methods A case-control study was conducted, including 63 VAIN cases and 64healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus （HPV） status. Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women （95% CI： 1.10-3.85; P=-0.024）. The patients with previous hysterectomy had an increased risk of VAIN （OR=4.69; P=0.003）. Patients with a history of cervical cancer or CIN were predisposed to VAIN （OR=78.75; P 〈0.0001）. The rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load （OR=126.00; P=0.000）. Multivariate analysis showed that HPV infection and a history of CIN or cervical cancer were still found to be significant in patients. Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN.
文摘Objective To evaluate the possibility of vaginal hysterectomy for patients with moderately enlarged uterus of benign lesions. Methods One hundred and seventeen women with benign uterine diseases underwent vaginal hysterectomy. These patients were divided into two groups according to uterine weight. Group Ⅰ contained 60 patients with uterine enlargement to a weight of 200 to 750 g, and group Ⅱ contained 57 patients with uterine weight of less than 200 g. Uterine morcellation was performed in some cases. The peri-operative data in both groups were analyzed. Results In group Ⅰ, 59 cases underwent transvaginal hysterectomy successfully, except 1 case con-verted to abdominal operation and the uterine morcellation was performed in 21 women. In group Ⅱ, all patients successfully underwent transvaginal hysterectomy without any assistance of special technique. The mean uterine weight of group Ⅰ was significantly heavier than that of group Ⅱ(280.18 ± 100.40 g vs 146.48 ± 35.19 g). The mean operating time was significantly longer for group Ⅰ than that for group Ⅱ(83.93 ± 26.26 minutes vs 35.22 ± 20.55 minutes). There were no significant differences in blood loss and complications between groupⅠ and group Ⅱ. There was no injury of urinary bladder or rectum, and no vaginal vault infection. Conclusions Vaginal hysterectomy of moderately enlarged uterus can be safely and effectively performed by experienced operators. In some cases, in order to reduce the uterine volume, uterine mor-cellation should be used to shorten operative time, reduce the bleeding, and lower the postoperative complications.
