The rational and effective implementation of epidemic prevention and control measures is crucial to controlling the spread of COVID-19, and vaccination is a key part to be considered in the development of epidemic pre...The rational and effective implementation of epidemic prevention and control measures is crucial to controlling the spread of COVID-19, and vaccination is a key part to be considered in the development of epidemic prevention and control strategies. In order to give full play to the greater role of vaccination strategies in epidemic prevention and control, more accurate and efficient vaccination strategies should be explored. Based on the classical SEIR dynamic model, this paper established a COVID-19 dynamic model of population age structure in the form of population grouping and combined with the transmission characteristics of the COVID-19 epidemic. An optimization model with the goal of minimizing daily infection was established to analyze the optimization studies on infection-related specificity of vaccination for different age groups under the condition of limited daily vaccine supply at the early stage of the epidemic, and to obtain the priority of vaccination strategies for Chinese age groups. And the effect of the heterogeneity of infection rate and hospitalization rate on the priority of vaccine allocation.展开更多
接种人类乳头瘤病毒(human papilloma virus,HPV)疫苗可预防HPV感染和HPV相关癌症。目前大多数国家采用2剂次HPV疫苗接种方案,但越来越多的研究发现接种单剂次HPV疫苗具有潜在的保护效果。鉴于宫颈癌的巨大全球疾病负担及因HPV疫苗供应...接种人类乳头瘤病毒(human papilloma virus,HPV)疫苗可预防HPV感染和HPV相关癌症。目前大多数国家采用2剂次HPV疫苗接种方案,但越来越多的研究发现接种单剂次HPV疫苗具有潜在的保护效果。鉴于宫颈癌的巨大全球疾病负担及因HPV疫苗供应紧张而造成国家或地区间的供应日益严重不平等现象,世界卫生组织免疫策略咨询专家组(Strategic Advisory Group of Experts on Immunization,SAGE)在2022年4月相关会议上表明,单剂次HPV疫苗与2剂次或3剂次疫苗接种方案的保护作用相当。本文就HPV疫苗接种现状和单剂次HPV疫苗保护作用的相关研究进行综述,并分析未来实施单剂HPV疫苗接种策略的机遇和挑战。展开更多
文摘The rational and effective implementation of epidemic prevention and control measures is crucial to controlling the spread of COVID-19, and vaccination is a key part to be considered in the development of epidemic prevention and control strategies. In order to give full play to the greater role of vaccination strategies in epidemic prevention and control, more accurate and efficient vaccination strategies should be explored. Based on the classical SEIR dynamic model, this paper established a COVID-19 dynamic model of population age structure in the form of population grouping and combined with the transmission characteristics of the COVID-19 epidemic. An optimization model with the goal of minimizing daily infection was established to analyze the optimization studies on infection-related specificity of vaccination for different age groups under the condition of limited daily vaccine supply at the early stage of the epidemic, and to obtain the priority of vaccination strategies for Chinese age groups. And the effect of the heterogeneity of infection rate and hospitalization rate on the priority of vaccine allocation.
文摘接种人类乳头瘤病毒(human papilloma virus,HPV)疫苗可预防HPV感染和HPV相关癌症。目前大多数国家采用2剂次HPV疫苗接种方案,但越来越多的研究发现接种单剂次HPV疫苗具有潜在的保护效果。鉴于宫颈癌的巨大全球疾病负担及因HPV疫苗供应紧张而造成国家或地区间的供应日益严重不平等现象,世界卫生组织免疫策略咨询专家组(Strategic Advisory Group of Experts on Immunization,SAGE)在2022年4月相关会议上表明,单剂次HPV疫苗与2剂次或3剂次疫苗接种方案的保护作用相当。本文就HPV疫苗接种现状和单剂次HPV疫苗保护作用的相关研究进行综述,并分析未来实施单剂HPV疫苗接种策略的机遇和挑战。
基金Supported by the National Natural Science Foundation of China(11201368)the Fundamental Research Funds for the Central Universities(Xi’an Jiaotong University)the Science and Technology Research Project of the Department of Education of Heilongjiang Province(12531495)
