Rationale: In a previously published trial on spinal acute non-traumatic pain, peripheral neuro- regenerative combination of UTP, CMP and hydroxocobalamin presented unexpected analgesicproperties. Objective: To corrob...Rationale: In a previously published trial on spinal acute non-traumatic pain, peripheral neuro- regenerative combination of UTP, CMP and hydroxocobalamin presented unexpected analgesicproperties. Objective: To corroborate analgesiceffects of UTP, CMP and hydroxocobalamin combination in a self-paired evolutionary model. Methods: Mean VAS scores from pretreatment, V2 (5th treatment day) and V3 (10th treatment day) were plotted and statistically analyzed (ANOVA) for differences. PFQ scores from pretreatment, V2, and V3 were analyzed using the chisquare test. Results: The difference between V3 and pretreatment mean VAS scores was statistically significant (p < 0.0001). The improvement in PFQ scores throughout the study was found to be statistically significant (p < 0.0001). Conclusion: The combination of UTP, CMP and hydroxocobalamin seems to have analgesic properties in mediumterm use. The complex peripheral neu-roregenerative pharmacodynamics of this combination provides a plausible basis for this finding. Further randomized studies are needed to explore this combination for the indication of neuropathic pain due to spinal structure involvement.展开更多
目的观察固肾降浊法联合西医常规疗法对于糖尿病肾病患者临床疗效的影响。方法选择糖尿病肾病患者196例,依照治疗方式不同分成观察组101例与对照组95例,2组均采用西医常规治疗,观察组在对照组基础上加服固肾降浊法中药方,12周后对比2组...目的观察固肾降浊法联合西医常规疗法对于糖尿病肾病患者临床疗效的影响。方法选择糖尿病肾病患者196例,依照治疗方式不同分成观察组101例与对照组95例,2组均采用西医常规治疗,观察组在对照组基础上加服固肾降浊法中药方,12周后对比2组临床疗效、中医证候积分、尿蛋白定量、肾功能指标、糖化血红蛋白、血脂治疗前后差异。结果观察组总有效率(85.1%,86/101)高于对照组(71.6%,68/95)(P<0.05);观察组中医证候积分均显著低于对照组(P<0.01),24 h UTP水平低于对照组(P<0.05),肾功能指标BUN水平较对照组低(P<0.05),HbA1c%较对照组低(P<0.01),血脂指标TC、TG水平较对照组低(P<0.05),LDL-C水平显著低于对照组(P<0.01)。结论糖尿病肾病肾虚浊毒瘀阻型患者采用固肾降浊法联合西医常规疗法可取得较好的临床效果,可使患者24 h UTP、HbA1c%、TG、LDL-C水平降低显著,对肾功能有一定的保护作用。展开更多
文摘Rationale: In a previously published trial on spinal acute non-traumatic pain, peripheral neuro- regenerative combination of UTP, CMP and hydroxocobalamin presented unexpected analgesicproperties. Objective: To corroborate analgesiceffects of UTP, CMP and hydroxocobalamin combination in a self-paired evolutionary model. Methods: Mean VAS scores from pretreatment, V2 (5th treatment day) and V3 (10th treatment day) were plotted and statistically analyzed (ANOVA) for differences. PFQ scores from pretreatment, V2, and V3 were analyzed using the chisquare test. Results: The difference between V3 and pretreatment mean VAS scores was statistically significant (p < 0.0001). The improvement in PFQ scores throughout the study was found to be statistically significant (p < 0.0001). Conclusion: The combination of UTP, CMP and hydroxocobalamin seems to have analgesic properties in mediumterm use. The complex peripheral neu-roregenerative pharmacodynamics of this combination provides a plausible basis for this finding. Further randomized studies are needed to explore this combination for the indication of neuropathic pain due to spinal structure involvement.
文摘目的观察固肾降浊法联合西医常规疗法对于糖尿病肾病患者临床疗效的影响。方法选择糖尿病肾病患者196例,依照治疗方式不同分成观察组101例与对照组95例,2组均采用西医常规治疗,观察组在对照组基础上加服固肾降浊法中药方,12周后对比2组临床疗效、中医证候积分、尿蛋白定量、肾功能指标、糖化血红蛋白、血脂治疗前后差异。结果观察组总有效率(85.1%,86/101)高于对照组(71.6%,68/95)(P<0.05);观察组中医证候积分均显著低于对照组(P<0.01),24 h UTP水平低于对照组(P<0.05),肾功能指标BUN水平较对照组低(P<0.05),HbA1c%较对照组低(P<0.01),血脂指标TC、TG水平较对照组低(P<0.05),LDL-C水平显著低于对照组(P<0.01)。结论糖尿病肾病肾虚浊毒瘀阻型患者采用固肾降浊法联合西医常规疗法可取得较好的临床效果,可使患者24 h UTP、HbA1c%、TG、LDL-C水平降低显著,对肾功能有一定的保护作用。
