The application of artificial neural network for pharmaceutical nondestructive quantitative analysis was investigated. The real data set from near infrared reflectance spectra of trimethoprim powder pharmaceutical wer...The application of artificial neural network for pharmaceutical nondestructive quantitative analysis was investigated. The real data set from near infrared reflectance spectra of trimethoprim powder pharmaceutical were used to built up artificial network to predict unknown samples. The factors affecting network were discussed. A new network evaluation criterion, the degree of approximation, was employed. Owing to good nonlinear multivariate calibration nature of ANN, the predicted result was reliable. [WT5HZ]展开更多
A monolithic molecularly imprinted polymer(monolithic MIP) for trimethoprim(TMP) was prepared by in situ polymerization method as the HPLC stationary phase. Methacrylic acid(MAA) and ethylene glycol dimethacrylate(EDM...A monolithic molecularly imprinted polymer(monolithic MIP) for trimethoprim(TMP) was prepared by in situ polymerization method as the HPLC stationary phase. Methacrylic acid(MAA) and ethylene glycol dimethacrylate(EDMA) were used as functional monomer and cross-linker, respectively. The obtained MIP monoliths were characterized by high performance liquid chromatography and scanning electron microscope. The SEM analysis result clearly shows that many macropores and flow-through pores were embedded in the network skeleton of the TMP-imprinted monolith, which allowed the mobile phase to flow through the monolithic MIPs with a very low flow resistance. When the flow rate was high to 9.0 mL/min, the backpressure was only 11.1 MPa. Moreover, the imprinting factor was up to 10.3, which demonstrates that the obtained monolithic MIP showed a strong affinity and selectivity to the template molecule.展开更多
文摘The application of artificial neural network for pharmaceutical nondestructive quantitative analysis was investigated. The real data set from near infrared reflectance spectra of trimethoprim powder pharmaceutical were used to built up artificial network to predict unknown samples. The factors affecting network were discussed. A new network evaluation criterion, the degree of approximation, was employed. Owing to good nonlinear multivariate calibration nature of ANN, the predicted result was reliable. [WT5HZ]
文摘A monolithic molecularly imprinted polymer(monolithic MIP) for trimethoprim(TMP) was prepared by in situ polymerization method as the HPLC stationary phase. Methacrylic acid(MAA) and ethylene glycol dimethacrylate(EDMA) were used as functional monomer and cross-linker, respectively. The obtained MIP monoliths were characterized by high performance liquid chromatography and scanning electron microscope. The SEM analysis result clearly shows that many macropores and flow-through pores were embedded in the network skeleton of the TMP-imprinted monolith, which allowed the mobile phase to flow through the monolithic MIPs with a very low flow resistance. When the flow rate was high to 9.0 mL/min, the backpressure was only 11.1 MPa. Moreover, the imprinting factor was up to 10.3, which demonstrates that the obtained monolithic MIP showed a strong affinity and selectivity to the template molecule.
