提出了一种基于均匀圆阵双基地MIMO雷达多目标多维角度估计的新算法。对阵列接收信号进行分析,表明其具有平行因子三线性模型特征,利用该模型低秩分解的唯一性条件,从分解得到的矩阵中联合估计出多维角度。该方法无需谱峰搜索,可实现参...提出了一种基于均匀圆阵双基地MIMO雷达多目标多维角度估计的新算法。对阵列接收信号进行分析,表明其具有平行因子三线性模型特征,利用该模型低秩分解的唯一性条件,从分解得到的矩阵中联合估计出多维角度。该方法无需谱峰搜索,可实现参数的同时估计与配对,与基于旋转不变参数估计技术(Estimation of signal parameters via rotational invariance techniques,ESPRIT)思想的算法相比具有更高的估计精度,而且在小样本数下也能较好地工作。仿真结果验证了该算法的有效性。展开更多
The interaction between BSA and epicatechin was studied using fluorescence quenching titrations combined with trilinear decomposition method and excitation-emission matrix(EEM)fluorescence.The resolved spectra were hi...The interaction between BSA and epicatechin was studied using fluorescence quenching titrations combined with trilinear decomposition method and excitation-emission matrix(EEM)fluorescence.The resolved spectra were highly similar with the actual ones which indicated that the resolved results were reliable.The relevant parameters of the binding process were obtained by quantifying each substance in the complicated mixtures in situ.The quenching was static quenching,epicatechin had a weak interaction with BSA and the binding site was one.The total concentration and the free concentration of quenchers had different effect on the system.The results demonstrated that the method exploited in this article is a useful tool to investigate complicated interactions,avoiding complicated pretreatment and simplify experimental procedure.展开更多
In this work, a smart strategy that combines three-way high performance liquid chromatography-diode array detection(HPLCDAD) data with second-order calibration method based on alternating trilinear decomposition(ATLD)...In this work, a smart strategy that combines three-way high performance liquid chromatography-diode array detection(HPLCDAD) data with second-order calibration method based on alternating trilinear decomposition(ATLD) algorithm was proposed for simultaneous determination of eleven non-steroidal anti-inflammatory drugs(NSAIDs) illegally added into Chinese patent drugs and health products. All target analytes were rapidly eluted out within 14.5 min under a simple gradient elution. With the aid of the prominent "second-order advantage" of the ATLD algorithm, three HPLC problems, i.e. peak overlaps, unknown interferences and baseline drift, could be mathematically calibrated, and pure signals of target analytes could be extracted out from heavy-interference but information-rich HPLC-DAD data. The average spiked recoveries for all target analytes were in the range of 95.9%–106.4% with standard deviations lower than 7.5%. Validation parameters including sensitivity(SEN), selectivity(SEL), limit of detection(LOD), limit of quantitation(LOQ) and precisions of intra-day and inter-day were calculated to validate the accuracy of the proposed method, quantitative results were further confirmed by the classic HPLC method, which proved that chemometrics-assisted HPLC-DAD analytical strategy was highly efficient, accurate and green for drug-abuse monitoring of NSAIDs in Chinese patent drugs and health products.展开更多
A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of ...A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of second-order calibration method based on alternating trilinear decomposition(ATLD) method. Re and Ir with weak fluorescence can be endowed with strong fluorescent property by changing the microenvironment in samples and improving the fluorescence quantum yield by using an appropriate micellar enhanced surfactant. The enhanced excitation-emission matrix fluorescence of Re and Ir can be accurately resolved and can simultaneously attain the optimal concentration even in the presence of a potentially strong intrinsic fluorescence from complex biological matrices, such as rat and human plasmas, by using the ATLD method, which completely exploits the "second-order advantage". The average recoveries of Re and Ir obtained from ATLD with the factor number of 3(N=3) were 101.0%±4.3% and 99.1%±4.1% for rat plasma and 100.5%±5.4% and 97.1%±3.6% for human plasma. Several statistical methods, including Student's t-test, figures of merit, and elliptical joint confidence region, have been utilized to evaluate the accuracy of the proposed method. Results show that the developed method can maintain second-order advantage in simultaneous determinations of the weak fluorescent analytes of interest in different biological plasma matrices.展开更多
This paper introduces a new source separation technique exploiting the time coherence of the source signals. The proposed approach relies only on stationary second order statistics. Blind Signal Separation (BSS) metho...This paper introduces a new source separation technique exploiting the time coherence of the source signals. The proposed approach relies only on stationary second order statistics. Blind Signal Separation (BSS) method using trilinear decomposition is proposed in this paper. Simulation results reveal that our proposed algorithm has the better blind signal separation performance than joint diagonalization method. Our proposed algorithm does not require whitening processing. Moreover, our proposed algorithm works well in the underdetermined condition, where the number of sources exceeds than the number of sensors.展开更多
文摘提出了一种基于均匀圆阵双基地MIMO雷达多目标多维角度估计的新算法。对阵列接收信号进行分析,表明其具有平行因子三线性模型特征,利用该模型低秩分解的唯一性条件,从分解得到的矩阵中联合估计出多维角度。该方法无需谱峰搜索,可实现参数的同时估计与配对,与基于旋转不变参数估计技术(Estimation of signal parameters via rotational invariance techniques,ESPRIT)思想的算法相比具有更高的估计精度,而且在小样本数下也能较好地工作。仿真结果验证了该算法的有效性。
基金financially supported by the National Natural Science Foundation of China(21175041)the National Basic Research Program of China(2012CB910602)
文摘The interaction between BSA and epicatechin was studied using fluorescence quenching titrations combined with trilinear decomposition method and excitation-emission matrix(EEM)fluorescence.The resolved spectra were highly similar with the actual ones which indicated that the resolved results were reliable.The relevant parameters of the binding process were obtained by quantifying each substance in the complicated mixtures in situ.The quenching was static quenching,epicatechin had a weak interaction with BSA and the binding site was one.The total concentration and the free concentration of quenchers had different effect on the system.The results demonstrated that the method exploited in this article is a useful tool to investigate complicated interactions,avoiding complicated pretreatment and simplify experimental procedure.
基金supported by the National Natural Science Foundation of China (21575039, 21775039, 21521063)
文摘In this work, a smart strategy that combines three-way high performance liquid chromatography-diode array detection(HPLCDAD) data with second-order calibration method based on alternating trilinear decomposition(ATLD) algorithm was proposed for simultaneous determination of eleven non-steroidal anti-inflammatory drugs(NSAIDs) illegally added into Chinese patent drugs and health products. All target analytes were rapidly eluted out within 14.5 min under a simple gradient elution. With the aid of the prominent "second-order advantage" of the ATLD algorithm, three HPLC problems, i.e. peak overlaps, unknown interferences and baseline drift, could be mathematically calibrated, and pure signals of target analytes could be extracted out from heavy-interference but information-rich HPLC-DAD data. The average spiked recoveries for all target analytes were in the range of 95.9%–106.4% with standard deviations lower than 7.5%. Validation parameters including sensitivity(SEN), selectivity(SEL), limit of detection(LOD), limit of quantitation(LOQ) and precisions of intra-day and inter-day were calculated to validate the accuracy of the proposed method, quantitative results were further confirmed by the classic HPLC method, which proved that chemometrics-assisted HPLC-DAD analytical strategy was highly efficient, accurate and green for drug-abuse monitoring of NSAIDs in Chinese patent drugs and health products.
基金supported by the National Natural Science Foundation of China (21205145, 21575039)the Open Funds of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University (201111)The Open Research Program (2015ZD001, 2015ZD002) from the Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei province
文摘A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of second-order calibration method based on alternating trilinear decomposition(ATLD) method. Re and Ir with weak fluorescence can be endowed with strong fluorescent property by changing the microenvironment in samples and improving the fluorescence quantum yield by using an appropriate micellar enhanced surfactant. The enhanced excitation-emission matrix fluorescence of Re and Ir can be accurately resolved and can simultaneously attain the optimal concentration even in the presence of a potentially strong intrinsic fluorescence from complex biological matrices, such as rat and human plasmas, by using the ATLD method, which completely exploits the "second-order advantage". The average recoveries of Re and Ir obtained from ATLD with the factor number of 3(N=3) were 101.0%±4.3% and 99.1%±4.1% for rat plasma and 100.5%±5.4% and 97.1%±3.6% for human plasma. Several statistical methods, including Student's t-test, figures of merit, and elliptical joint confidence region, have been utilized to evaluate the accuracy of the proposed method. Results show that the developed method can maintain second-order advantage in simultaneous determinations of the weak fluorescent analytes of interest in different biological plasma matrices.
文摘研究单基地十字阵多输入多输出(multiple-input multiple-output,MIMO)雷达中目标二维角度参数估计的问题。已有的算法往往忽略了信源矩阵中的类Vandermonde结构,而这种特殊的结构可以提升参数估计精度。基于均匀线形阵列(uniform linear array,ULA)的中心对称特性和目标参数矩阵中的类Vandermonde结构,提出一种基于改进的三线性分解的二维角度估计算法。首先利用酉变换的方法构造阵列增广输出矩阵,再将二维角度估计与三线性模型相联系。由于增广输出使得阵列的虚拟孔径增大,因而本文所提算法的参数估计精度要优于传统三线性估计算法。此外,本文提及的改进算法不需进行谱峰搜索及奇异值分解,并且能对估计的二维目标角度自动配对,最后的仿真结果验证了本文算法的有效性。
基金Supported by the National Natural Science Foundation of China (60801052)Aeronautical Science Foundation of China (2009ZC52036)
文摘This paper introduces a new source separation technique exploiting the time coherence of the source signals. The proposed approach relies only on stationary second order statistics. Blind Signal Separation (BSS) method using trilinear decomposition is proposed in this paper. Simulation results reveal that our proposed algorithm has the better blind signal separation performance than joint diagonalization method. Our proposed algorithm does not require whitening processing. Moreover, our proposed algorithm works well in the underdetermined condition, where the number of sources exceeds than the number of sensors.
