Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate（la）, PEG （600） dibenzo[5,6]coumarin-3-carboxylate（1b）, triethylene-glycol di[7-（N,N＇-diethylamino）]-coumarin-3-carboxy...Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate（la）, PEG （600） dibenzo[5,6]coumarin-3-carboxylate（1b）, triethylene-glycol di[7-（N,N＇-diethylamino）]-coumarin-3-carboxylate（2a）, were synthesized. The cytotoxic effect of these compounds, along with benzo[5,6]coumarin-3-carboxylic acid（l） and 7-（N,N＇-diethylamino）-coumarin-3-carboxylic acid（2）, against the SGC-7901 cell lines were determined by Sulforhodamine B（SRB） assay. The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound la according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.展开更多
An inherent problem with natural gas production or transmission is the formation of gas hydrates, which can lead to safety hazards for production/transportation systems, and substantial economic risks. Hydrate inhibit...An inherent problem with natural gas production or transmission is the formation of gas hydrates, which can lead to safety hazards for production/transportation systems, and substantial economic risks. Hydrate inhibition with different inhibitors such as, methanol, ethylene glycol （EG）, triethylene glycol （TEG）, and sodium chloride solution continues to play a critical role in many operations. An understanding of when the hydrates form in the presence of these hydrate inhibitors, is therefore necessary to overcome hydrate problems. Several thermodynamic models have been proposed for predicting the hydrate formation conditions in aqueous solutions containing methanol/glycols and electrolytes. However, available models have limitations that include the types of liquid, compositions of fluids, and inhibitors used. The aim of this study is to develop a simple-to-use correlation for accurate prediction of hydrate-forming pressures of pure alkanes in the presence of different hydrate inhibitors, where the obtained results illustrate good agreement with the reported experimental data.展开更多
基金Supported by the National Natural Science Foundation of China(No.60776006)the Research Fund of Lanzhou Jiaotong University,China(No.40745)
文摘Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate（la）, PEG （600） dibenzo[5,6]coumarin-3-carboxylate（1b）, triethylene-glycol di[7-（N,N＇-diethylamino）]-coumarin-3-carboxylate（2a）, were synthesized. The cytotoxic effect of these compounds, along with benzo[5,6]coumarin-3-carboxylic acid（l） and 7-（N,N＇-diethylamino）-coumarin-3-carboxylic acid（2）, against the SGC-7901 cell lines were determined by Sulforhodamine B（SRB） assay. The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound la according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.
文摘An inherent problem with natural gas production or transmission is the formation of gas hydrates, which can lead to safety hazards for production/transportation systems, and substantial economic risks. Hydrate inhibition with different inhibitors such as, methanol, ethylene glycol （EG）, triethylene glycol （TEG）, and sodium chloride solution continues to play a critical role in many operations. An understanding of when the hydrates form in the presence of these hydrate inhibitors, is therefore necessary to overcome hydrate problems. Several thermodynamic models have been proposed for predicting the hydrate formation conditions in aqueous solutions containing methanol/glycols and electrolytes. However, available models have limitations that include the types of liquid, compositions of fluids, and inhibitors used. The aim of this study is to develop a simple-to-use correlation for accurate prediction of hydrate-forming pressures of pure alkanes in the presence of different hydrate inhibitors, where the obtained results illustrate good agreement with the reported experimental data.
