目的评价拉莫三嗪对癫癎患者认知功能以及生活质量的影响。方法对91例新诊断的癫癎患者给予拉莫三嗪治疗,并在用药前及用药16周后进行认知功能评定及生活质量调查。认知功能评定工具包括听觉词语测验、逻辑记忆测验、数字符号转换测验、...目的评价拉莫三嗪对癫癎患者认知功能以及生活质量的影响。方法对91例新诊断的癫癎患者给予拉莫三嗪治疗,并在用药前及用药16周后进行认知功能评定及生活质量调查。认知功能评定工具包括听觉词语测验、逻辑记忆测验、数字符号转换测验、Stroop 字色干扰测验、连线测验、言语流畅性测验、韦氏积木测验、数字广度测验及 Boston 命名测验;生活质量调查采用患者生活质量评定量表-31(QOLIE-31)。结果癫癎患者应用拉莫三嗪治疗16周后与用药前比较,各项得分均有提高,其中以即刻与延迟词语记忆、情景记忆、执行功能、空间知觉能力以及言语命名功能方面改善显著。生活质量方面,QOLIE-31量表的7个测评方面及1个总体健康评价中,6项分值在用药后较用药前有所提高,其中"对癫癎的担心"(38.81±16.06,16周后45.68±15.18,P<0.01)、"总体生活质量"(59.12±13.50,16周后64.99±13.33,P<0.01)、"社会功能"(64.59±25.14,16周后69.41±22.70,P<0.05)以及"总体自身健康评价"(71.18±13.73,16周后76.75±11.30,P<0.01)4项的得分差异有统计学意义。结论拉莫三嗪单药治疗新诊断癫癎患者可在短期内改善其认知功能,并提高生活质量。展开更多
Density functional theory B3LYP is employed to obtain the optimized geometries of the ground state and interaction energy for triazines and water complexes. The results show that the 1,2,3-triazine-water, 1,2,4-triazi...Density functional theory B3LYP is employed to obtain the optimized geometries of the ground state and interaction energy for triazines and water complexes. The results show that the 1,2,3-triazine-water, 1,2,4-triazine-water and 1,3,5-triazine-water complex on the ground state have Cs, Cs and C1 symmetry, and strong hydrogen bonding interaction with ?17.83, ?17.38 and ?13.55 kJ/mol after basis set superposition error and zero-point vibration energy correction, respectively, and large red-shift for the symmetric H─O stretching vibration frequencies forming N···H─O hydrogen bond in the triazines complex. The first singlet (n, π*) vertical excitation energy of the monomer and the hydrogen bonding complexes between triazines and water is investigated by time-dependent density functional theory.展开更多
The main cash crop in Togo is cotton, with about 70% of agricultural exports. This crop is very dependent on the use of chemical inputs, in particular pesticides. Pesticides used in cotton farming in Togo include orga...The main cash crop in Togo is cotton, with about 70% of agricultural exports. This crop is very dependent on the use of chemical inputs, in particular pesticides. Pesticides used in cotton farming in Togo include organochlorines, triazines, organophosphates and pyrethroids. We conducted a study on the impact of these pesticide use, in particular organochlorines and triazines, on cotton farming soils. We chose the Plateaux region (southern Togo) as the study area because of its high cotton production. Analysis was carried out on crop soil samples at the 0 - 20 cm horizon. Several pesticide residues were found: simazine (0.051 to 0.103 μg/Kg soil);atrazine (0.149 to 0.197 μg/Kg soil);lindane (0.259 to 0.672 μg/Kg soil);β-endosulfan (1.37 to 5.727 μg/Kg soil);dieldrin (0.063 to 1.16 μg/Kg soil);endrin (0.512 μg/Kg soil), Heptachlor (0.489 to 1.243 μg/Kg soil);Heptachlor epoxide (0.928 to 1.633 μg/Kg soil);[2,4'DDT] (0.257 μg/Kg soil);[4,4'DDE] (0.262 μg/Kg soil). These results show pesticide contamination of cotton farming soils.展开更多
The imine salt was formed initially by the addition of an organolithium compound to the aromatic nitricle.This type of reaction usually leads to cyclic products,such as triazines.We discussed the mechanism of organoli...The imine salt was formed initially by the addition of an organolithium compound to the aromatic nitricle.This type of reaction usually leads to cyclic products,such as triazines.We discussed the mechanism of organolithium compounds catalyzed trimerization of nitriles and study the catalystic charateristics.Using this new method,the yield of triazines was improved.展开更多
文摘目的评价拉莫三嗪对癫癎患者认知功能以及生活质量的影响。方法对91例新诊断的癫癎患者给予拉莫三嗪治疗,并在用药前及用药16周后进行认知功能评定及生活质量调查。认知功能评定工具包括听觉词语测验、逻辑记忆测验、数字符号转换测验、Stroop 字色干扰测验、连线测验、言语流畅性测验、韦氏积木测验、数字广度测验及 Boston 命名测验;生活质量调查采用患者生活质量评定量表-31(QOLIE-31)。结果癫癎患者应用拉莫三嗪治疗16周后与用药前比较,各项得分均有提高,其中以即刻与延迟词语记忆、情景记忆、执行功能、空间知觉能力以及言语命名功能方面改善显著。生活质量方面,QOLIE-31量表的7个测评方面及1个总体健康评价中,6项分值在用药后较用药前有所提高,其中"对癫癎的担心"(38.81±16.06,16周后45.68±15.18,P<0.01)、"总体生活质量"(59.12±13.50,16周后64.99±13.33,P<0.01)、"社会功能"(64.59±25.14,16周后69.41±22.70,P<0.05)以及"总体自身健康评价"(71.18±13.73,16周后76.75±11.30,P<0.01)4项的得分差异有统计学意义。结论拉莫三嗪单药治疗新诊断癫癎患者可在短期内改善其认知功能,并提高生活质量。
基金This project has been supported by Sichuan Youth Foundation (Grant No. 05ZQ026-054) the Natural Science Foundation of Sichuan Education Bureau (Grant No. 2005A102).
文摘Density functional theory B3LYP is employed to obtain the optimized geometries of the ground state and interaction energy for triazines and water complexes. The results show that the 1,2,3-triazine-water, 1,2,4-triazine-water and 1,3,5-triazine-water complex on the ground state have Cs, Cs and C1 symmetry, and strong hydrogen bonding interaction with ?17.83, ?17.38 and ?13.55 kJ/mol after basis set superposition error and zero-point vibration energy correction, respectively, and large red-shift for the symmetric H─O stretching vibration frequencies forming N···H─O hydrogen bond in the triazines complex. The first singlet (n, π*) vertical excitation energy of the monomer and the hydrogen bonding complexes between triazines and water is investigated by time-dependent density functional theory.
文摘The main cash crop in Togo is cotton, with about 70% of agricultural exports. This crop is very dependent on the use of chemical inputs, in particular pesticides. Pesticides used in cotton farming in Togo include organochlorines, triazines, organophosphates and pyrethroids. We conducted a study on the impact of these pesticide use, in particular organochlorines and triazines, on cotton farming soils. We chose the Plateaux region (southern Togo) as the study area because of its high cotton production. Analysis was carried out on crop soil samples at the 0 - 20 cm horizon. Several pesticide residues were found: simazine (0.051 to 0.103 μg/Kg soil);atrazine (0.149 to 0.197 μg/Kg soil);lindane (0.259 to 0.672 μg/Kg soil);β-endosulfan (1.37 to 5.727 μg/Kg soil);dieldrin (0.063 to 1.16 μg/Kg soil);endrin (0.512 μg/Kg soil), Heptachlor (0.489 to 1.243 μg/Kg soil);Heptachlor epoxide (0.928 to 1.633 μg/Kg soil);[2,4'DDT] (0.257 μg/Kg soil);[4,4'DDE] (0.262 μg/Kg soil). These results show pesticide contamination of cotton farming soils.
文摘The imine salt was formed initially by the addition of an organolithium compound to the aromatic nitricle.This type of reaction usually leads to cyclic products,such as triazines.We discussed the mechanism of organolithium compounds catalyzed trimerization of nitriles and study the catalystic charateristics.Using this new method,the yield of triazines was improved.
