Background The receptor tyrosine kinase-like orphan receptor 2 （ROR2） gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non ...Background The receptor tyrosine kinase-like orphan receptor 2 （ROR2） gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non syndromic cleft lip with or without cleft palate in humans.The aim of this study was to investigate the possible association between ROR2 gene and non-syndromic oral clefts.Methods Here we tested 38 eligible single-nucleotide polymorphisms （SNPs） in ROR2 gene in 297 non-syndromic cleft lip with or without cleft palate and in 82 non-syndromic cleft palate case parent trios recruited from Asia and Maryland.Family Based Association Test was used to test for deviation from Mendelian inheritance.Plink software was used to test potential parent of origin effect.Possible maternally mediated in utero effects were assessed using the TRlad Multi-Marker approach under an assumption of mating symmetry in the population.Results Significant evidence of linkage and association was shown for 3 SNPs （rs7858435,rs10820914 and rs3905385） among 57 Asian non-syndromic cleft palate trios in Family Based Association Tests.P values for these 3 SNPs equaled to 0.000068,0.000115 and 0.000464 respectively which were all less than the significance level （0.05/38=0.0013） adjusted by strict Bonferroni correction.Relevant odds ratios for the risk allele were 3.42 （1.80-6.50）,3.45 （1.75-6.67） and 2.94 （1.56-5.56）,respectively.Statistical evidence of linkage and association was not shown for study groups other than non-syndromic cleft palate.Neither evidence for parent-of-origin nor maternal genotypic effect was shown for any of the ROR2 markers in our analysis for all study groups.Conclusion Our results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate.展开更多
当前中波前向解码传输控制信道一般设定为单层级端口传输,传输速度较慢,精度与通信定位能力较弱,误码率较高。分析及验证中波隐藏通信前向解码传输控制技术,综合前向解码传输控制的需求及标准,预处理基础隐藏前向解码,在标定的通信范围...当前中波前向解码传输控制信道一般设定为单层级端口传输,传输速度较慢,精度与通信定位能力较弱,误码率较高。分析及验证中波隐藏通信前向解码传输控制技术,综合前向解码传输控制的需求及标准,预处理基础隐藏前向解码,在标定的通信范围内布设中波多维控制节点,构建多端口的传输控制信道,营造稳定的控制环境,提高控制响应速度,实现同步通信定位。构建中波无线隐藏通信前向解码传输控制模型,采用嵌入修正传输实现前向解码控制处理。测试结果表明,对比传统数字信号处理(Digital Signal Processing,DSP)与现场可编程门阵列(Field-Programmable Gate Array,FPGA)的高速光纤总线通信控制测试组和传统区块链隐蔽通信模型控制测试组,中波隐藏通信前线解码控制测试得出的控制解码率相对较低,对于前向解码的传输控制效果较好、误差较小且传输控制程序明确,具有实际应用价值。展开更多
General pedigrees are very common in farm animals,and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative tra...General pedigrees are very common in farm animals,and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits.In this paper,we proposed a new transmission disequilibrium test approach,called the pedigree transmission disequilibrium test,which deals with general pedigrees and quantitative traits in farm animals.Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT,our approach performed better with higher power and lower type I error,especially in scenarios where the quantitative trait locus (QTL) effect was small.We also investigated the application of our approach in selective genotyping design.Our simulation studies indicated that it was plausible to implement a selective genotyping strategy in the proposed pedigree transmission disequilibrium test.We found that our approach performed equally well or better when only some proportion of the individuals in the two tails were genotyped compared with its performance when all the individuals in the pedigree were genotyped.展开更多
电力监控系统环境中存在过多噪声因素干扰,导致通信效率和质量低。为此,提出一种基于传输控制协议/网际协议(transmission control protocol/internet protocol,TCP/IP)与关联规则的多线程通信算法。将背景噪声看作电力监控信号的突变现...电力监控系统环境中存在过多噪声因素干扰,导致通信效率和质量低。为此,提出一种基于传输控制协议/网际协议(transmission control protocol/internet protocol,TCP/IP)与关联规则的多线程通信算法。将背景噪声看作电力监控信号的突变现象,查找回应突变函数的信号值,利用谐波分离算法,去除背景噪声。根据不同线程的传输特点,采用TCP/IP协议建立通信程序包,分别设置句柄、终止、挂起以及执行函数,为不同线程的通信数据,匹配不同的通信协议。试验结果证明:对电力监控系统源设备的传输信号多线程通信时,通信信号波频变化最为平稳,在0~2000 s的采样区间内,未出现传输为0现象;对背景噪声去噪后,波形相比原始信号变化明显较为稳定,没有出现过高或过低的幅值变化。所提方法通信信号表达平稳、效率较高,对原始信号的保留效果较好,去噪能力很强。展开更多
文摘Background The receptor tyrosine kinase-like orphan receptor 2 （ROR2） gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non syndromic cleft lip with or without cleft palate in humans.The aim of this study was to investigate the possible association between ROR2 gene and non-syndromic oral clefts.Methods Here we tested 38 eligible single-nucleotide polymorphisms （SNPs） in ROR2 gene in 297 non-syndromic cleft lip with or without cleft palate and in 82 non-syndromic cleft palate case parent trios recruited from Asia and Maryland.Family Based Association Test was used to test for deviation from Mendelian inheritance.Plink software was used to test potential parent of origin effect.Possible maternally mediated in utero effects were assessed using the TRlad Multi-Marker approach under an assumption of mating symmetry in the population.Results Significant evidence of linkage and association was shown for 3 SNPs （rs7858435,rs10820914 and rs3905385） among 57 Asian non-syndromic cleft palate trios in Family Based Association Tests.P values for these 3 SNPs equaled to 0.000068,0.000115 and 0.000464 respectively which were all less than the significance level （0.05/38=0.0013） adjusted by strict Bonferroni correction.Relevant odds ratios for the risk allele were 3.42 （1.80-6.50）,3.45 （1.75-6.67） and 2.94 （1.56-5.56）,respectively.Statistical evidence of linkage and association was not shown for study groups other than non-syndromic cleft palate.Neither evidence for parent-of-origin nor maternal genotypic effect was shown for any of the ROR2 markers in our analysis for all study groups.Conclusion Our results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate.
文摘当前中波前向解码传输控制信道一般设定为单层级端口传输,传输速度较慢,精度与通信定位能力较弱,误码率较高。分析及验证中波隐藏通信前向解码传输控制技术,综合前向解码传输控制的需求及标准,预处理基础隐藏前向解码,在标定的通信范围内布设中波多维控制节点,构建多端口的传输控制信道,营造稳定的控制环境,提高控制响应速度,实现同步通信定位。构建中波无线隐藏通信前向解码传输控制模型,采用嵌入修正传输实现前向解码控制处理。测试结果表明,对比传统数字信号处理(Digital Signal Processing,DSP)与现场可编程门阵列(Field-Programmable Gate Array,FPGA)的高速光纤总线通信控制测试组和传统区块链隐蔽通信模型控制测试组,中波隐藏通信前线解码控制测试得出的控制解码率相对较低,对于前向解码的传输控制效果较好、误差较小且传输控制程序明确,具有实际应用价值。
基金supported by the Scientific Research Foundation for Returned Scholars,Ministry of Education of ChinaNational Natural Science Foundation of China(30800776)+2 种基金the Program for Changjiang Scholar and Innovation Research Team in University(IRT1191)the Beijing Science and Technology Ministry Project(Z101105000810001)the"948"of Ministry of Agriculture Project,China(2011-G2A)
文摘General pedigrees are very common in farm animals,and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits.In this paper,we proposed a new transmission disequilibrium test approach,called the pedigree transmission disequilibrium test,which deals with general pedigrees and quantitative traits in farm animals.Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT,our approach performed better with higher power and lower type I error,especially in scenarios where the quantitative trait locus (QTL) effect was small.We also investigated the application of our approach in selective genotyping design.Our simulation studies indicated that it was plausible to implement a selective genotyping strategy in the proposed pedigree transmission disequilibrium test.We found that our approach performed equally well or better when only some proportion of the individuals in the two tails were genotyped compared with its performance when all the individuals in the pedigree were genotyped.
文摘电力监控系统环境中存在过多噪声因素干扰,导致通信效率和质量低。为此,提出一种基于传输控制协议/网际协议(transmission control protocol/internet protocol,TCP/IP)与关联规则的多线程通信算法。将背景噪声看作电力监控信号的突变现象,查找回应突变函数的信号值,利用谐波分离算法,去除背景噪声。根据不同线程的传输特点,采用TCP/IP协议建立通信程序包,分别设置句柄、终止、挂起以及执行函数,为不同线程的通信数据,匹配不同的通信协议。试验结果证明:对电力监控系统源设备的传输信号多线程通信时,通信信号波频变化最为平稳,在0~2000 s的采样区间内,未出现传输为0现象;对背景噪声去噪后,波形相比原始信号变化明显较为稳定,没有出现过高或过低的幅值变化。所提方法通信信号表达平稳、效率较高,对原始信号的保留效果较好,去噪能力很强。
