Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal Pharmacopeia.Leaves of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in ...Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal Pharmacopeia.Leaves of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health abnormalities.Objective:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of F.aurea L.(herein afterwards referred to as ELEFA)in albino rats of both sexes.Methods:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of F.aurea.In the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was administered.For the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew copulation.Male groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled water.Standard analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney histopathology.Results:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological properties.These bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic acid.In the acute toxicity,no death was recorded within 24 h following oral administration of ELEFA.Remarkably,haematological and renal biomarkers remained unaltered post-ELEFA administration.However,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative stress.Conclusion:The study emphasized caution regarding higher ELEFA doses,highlighting poten展开更多
Objective:To investigate the socio-economics and medicinal utilization of Spondia monbin, commonly known as plum in English and iyeye in Yoruba.Methods:Three communities were selected in Abeokuta which was Itoku,Kuto,...Objective:To investigate the socio-economics and medicinal utilization of Spondia monbin, commonly known as plum in English and iyeye in Yoruba.Methods:Three communities were selected in Abeokuta which was Itoku,Kuto,and Omida using purposive random sampling technique because of the concentration of users in the area.Structured questionnaire was administered to randomly selected marketers,consumers and herbalists from the three communities.Utilization and marketing margin were descriptively analyzed.Results:The results showed that the leaves were being used for child birth aid,cough,sore throat,efu dudu,antiseptic soap,malaria and stomachic.The bark uses included child birth aid,inflammation concoction, fever,stomachic,malaria,and efu dudu.The uses of the fruit included cure for dizziness, stomachic,eaten as food,and fibroid.The seed were also being used for child birth aid,fibroid, and stomachic.The marketing margin analyses revealed that trading on the plants was profitable with the bark having the highest margin which showed the level of its profitability.Conclusions: The study reveals the medicinal potentials and the socioeconomic importance of Spondia mombin hence the need to conserve the species from unsustainable exploitation to ensure its availability.展开更多
文摘Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal Pharmacopeia.Leaves of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health abnormalities.Objective:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of F.aurea L.(herein afterwards referred to as ELEFA)in albino rats of both sexes.Methods:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of F.aurea.In the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was administered.For the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew copulation.Male groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled water.Standard analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney histopathology.Results:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological properties.These bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic acid.In the acute toxicity,no death was recorded within 24 h following oral administration of ELEFA.Remarkably,haematological and renal biomarkers remained unaltered post-ELEFA administration.However,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative stress.Conclusion:The study emphasized caution regarding higher ELEFA doses,highlighting poten
文摘Objective:To investigate the socio-economics and medicinal utilization of Spondia monbin, commonly known as plum in English and iyeye in Yoruba.Methods:Three communities were selected in Abeokuta which was Itoku,Kuto,and Omida using purposive random sampling technique because of the concentration of users in the area.Structured questionnaire was administered to randomly selected marketers,consumers and herbalists from the three communities.Utilization and marketing margin were descriptively analyzed.Results:The results showed that the leaves were being used for child birth aid,cough,sore throat,efu dudu,antiseptic soap,malaria and stomachic.The bark uses included child birth aid,inflammation concoction, fever,stomachic,malaria,and efu dudu.The uses of the fruit included cure for dizziness, stomachic,eaten as food,and fibroid.The seed were also being used for child birth aid,fibroid, and stomachic.The marketing margin analyses revealed that trading on the plants was profitable with the bark having the highest margin which showed the level of its profitability.Conclusions: The study reveals the medicinal potentials and the socioeconomic importance of Spondia mombin hence the need to conserve the species from unsustainable exploitation to ensure its availability.
