目的:观察注射用薏苡仁油对肿瘤患者行蒽环类(anthracycline,ATC)药物化疗引起的心脏不良反应的防治作用。方法:88例接受ATC化疗的恶性肿瘤患者随机分为实验组和对照组。实验组44例,在化疗同时给予注射用薏苡仁油注射液200mL静脉滴注,每...目的:观察注射用薏苡仁油对肿瘤患者行蒽环类(anthracycline,ATC)药物化疗引起的心脏不良反应的防治作用。方法:88例接受ATC化疗的恶性肿瘤患者随机分为实验组和对照组。实验组44例,在化疗同时给予注射用薏苡仁油注射液200mL静脉滴注,每天1次,连用2周;对照组44例,仅接受化疗而不使用注射用薏苡仁油。治疗前后检查心电图和超声心动图中的左心室舒张末期内径(lef tventricular internal diameter in diastole,LVDd)、左心室收缩末期内径(left ventricular internal diameter in systole,LVDs)、舒张早期与晚期充盈速度比值(E/A)、射血分数(ejection fraction,EF)和短轴缩短率(fraction of shortening,FS)等各项指标。结果:化疗后实验组与对照组EF和FS的差异无统计学意义(P>0.05),而LVDd、LVDs和E/A及心电图异常改变的差异有统计学意义(P<0.05)。结论:注射用薏苡仁油对ATC所导致的急性心脏不良反应有一定的防治作用。展开更多
Background The purpose of the study was to evaluate the role of neoadjuvant chemotherapy and embolization via the anterior branches of the bilateral internal iliac arteries in treating patients with advanced ovarian ...Background The purpose of the study was to evaluate the role of neoadjuvant chemotherapy and embolization via the anterior branches of the bilateral internal iliac arteries in treating patients with advanced ovarian epithelial carcinoma.Methods Forty-two patients with advanced ovarian epithelial carcinoma (study group) were treated via the anterior branches of the bilateral internal iliac arteries after cytoreductive surgery and 7 courses of adjuvant platinum-based combination chemotherapy. Primary cytoreductive surgery was performed in 43 patients with advanced ovarian epithelial carcinoma (control group), and then followed by 8 courses of adjuvant platinum-based combination chemotherapy. The rate of optimal cytoreductive surgery, survival rate, blood loss during operation and operative time were investigated in the two groups. Statistical significance was asessed using Student’s t test, the Chi-squre test and the log-rank test. Results In the study group, the rate of optimum debulking after platinum-based chemotherapy and embolization via the anterior branches of the bilateral internal iliac arteries was 71.43%(30/42) (χ2=10.06, P<0.005), and 9 (21.43%) of the 42 patients showed no gross residual disease after surgery. Blood loss and operative time were significantly decreased in the study group as compared with those in the control group (665.24±37.61 ml: 849.31±41.20 ml, t_1=33.21, P_1<0.001; 4.23±0.21 hours: 6.15±0.38 hours, t_2=28.92, P_2<0.01). In the study group,the mean survival time and the median overall survival were 33.66 months (95% CI, 24.73 to 42.58) and 26.00 months (95% CI, 19.22 to 32.78), respectively. The median disease-free interval was 18.20 months. In the control group, the mean survival time and the median overall survival were 32.38 months (95% CI, 24.92 to 39.84) and 25.00 months (95% CI, 22.80 to 27.20), respectively. The median disease-free interval was 14.20 months.The overall survival rates were not significantly different between the two groups (χ2=6.48,P>0.05).展开更多
文摘目的:观察注射用薏苡仁油对肿瘤患者行蒽环类(anthracycline,ATC)药物化疗引起的心脏不良反应的防治作用。方法:88例接受ATC化疗的恶性肿瘤患者随机分为实验组和对照组。实验组44例,在化疗同时给予注射用薏苡仁油注射液200mL静脉滴注,每天1次,连用2周;对照组44例,仅接受化疗而不使用注射用薏苡仁油。治疗前后检查心电图和超声心动图中的左心室舒张末期内径(lef tventricular internal diameter in diastole,LVDd)、左心室收缩末期内径(left ventricular internal diameter in systole,LVDs)、舒张早期与晚期充盈速度比值(E/A)、射血分数(ejection fraction,EF)和短轴缩短率(fraction of shortening,FS)等各项指标。结果:化疗后实验组与对照组EF和FS的差异无统计学意义(P>0.05),而LVDd、LVDs和E/A及心电图异常改变的差异有统计学意义(P<0.05)。结论:注射用薏苡仁油对ATC所导致的急性心脏不良反应有一定的防治作用。
文摘Background The purpose of the study was to evaluate the role of neoadjuvant chemotherapy and embolization via the anterior branches of the bilateral internal iliac arteries in treating patients with advanced ovarian epithelial carcinoma.Methods Forty-two patients with advanced ovarian epithelial carcinoma (study group) were treated via the anterior branches of the bilateral internal iliac arteries after cytoreductive surgery and 7 courses of adjuvant platinum-based combination chemotherapy. Primary cytoreductive surgery was performed in 43 patients with advanced ovarian epithelial carcinoma (control group), and then followed by 8 courses of adjuvant platinum-based combination chemotherapy. The rate of optimal cytoreductive surgery, survival rate, blood loss during operation and operative time were investigated in the two groups. Statistical significance was asessed using Student’s t test, the Chi-squre test and the log-rank test. Results In the study group, the rate of optimum debulking after platinum-based chemotherapy and embolization via the anterior branches of the bilateral internal iliac arteries was 71.43%(30/42) (χ2=10.06, P<0.005), and 9 (21.43%) of the 42 patients showed no gross residual disease after surgery. Blood loss and operative time were significantly decreased in the study group as compared with those in the control group (665.24±37.61 ml: 849.31±41.20 ml, t_1=33.21, P_1<0.001; 4.23±0.21 hours: 6.15±0.38 hours, t_2=28.92, P_2<0.01). In the study group,the mean survival time and the median overall survival were 33.66 months (95% CI, 24.73 to 42.58) and 26.00 months (95% CI, 19.22 to 32.78), respectively. The median disease-free interval was 18.20 months. In the control group, the mean survival time and the median overall survival were 32.38 months (95% CI, 24.92 to 39.84) and 25.00 months (95% CI, 22.80 to 27.20), respectively. The median disease-free interval was 14.20 months.The overall survival rates were not significantly different between the two groups (χ2=6.48,P>0.05).
