Iatrogenic ureteral injuries and strictures are relatively common complication of pelvic surgery and radiation treatment.Left untreated they are associated with severe shortand long-term complications such as urinoma,...Iatrogenic ureteral injuries and strictures are relatively common complication of pelvic surgery and radiation treatment.Left untreated they are associated with severe shortand long-term complications such as urinoma,septic state,renal failure,and loss of a renal unit.Treatment depends on timing of diagnosis,as well as extent of injury,and ranges from simple endoscopic management to complex surgical reconstruction under usage of pedicled grafts.While recent advances in ureteral tissue engineering are promising the topic is still underreported.Historically a domain of open surgery,laparoscopic and robotic-assisted approaches have proven their feasibility in small case series,and are increasingly being utilized as means of reconstructive surgery.This review aims to give an outline of incidence and treatment of ureteral injuries and strictures in light of the latest advances.展开更多
目的:探讨手术创伤引起的海马炎症反应对老年小鼠术后认知功能的影响。方法:96只雄性昆明小鼠随机分为对照组(NS组)、麻醉组(Ane组)、假手术组(Sham组)和手术组(Sur组)4组(n均为24)。使用Morris水迷宫进行认知功能测试。测试完毕后,采用...目的:探讨手术创伤引起的海马炎症反应对老年小鼠术后认知功能的影响。方法:96只雄性昆明小鼠随机分为对照组(NS组)、麻醉组(Ane组)、假手术组(Sham组)和手术组(Sur组)4组(n均为24)。使用Morris水迷宫进行认知功能测试。测试完毕后,采用Western blot和Real Time RT-PCR检测海马IL-1β、IL-6、TNF-α蛋白及mRNA表达水平。结果:术后第1、3、7天,4组动物目标象限停留时间百分比及1min内穿台次数差异有统计学意义(P均<0.05),且Sur组低于其他3组;4组动物海马IL-1β、IL-6、TNF-α蛋白及mRNA的表达差异有统计学意义(P均<0.001),Sur组较其他3组表达上调。结论:手术创伤能够引起老年小鼠术后认知功能障碍,其机制可能与术后海马组织中IL-1β、IL-6及TNF-α的表达上调有关。展开更多
文摘Iatrogenic ureteral injuries and strictures are relatively common complication of pelvic surgery and radiation treatment.Left untreated they are associated with severe shortand long-term complications such as urinoma,septic state,renal failure,and loss of a renal unit.Treatment depends on timing of diagnosis,as well as extent of injury,and ranges from simple endoscopic management to complex surgical reconstruction under usage of pedicled grafts.While recent advances in ureteral tissue engineering are promising the topic is still underreported.Historically a domain of open surgery,laparoscopic and robotic-assisted approaches have proven their feasibility in small case series,and are increasingly being utilized as means of reconstructive surgery.This review aims to give an outline of incidence and treatment of ureteral injuries and strictures in light of the latest advances.
文摘目的:探讨手术创伤引起的海马炎症反应对老年小鼠术后认知功能的影响。方法:96只雄性昆明小鼠随机分为对照组(NS组)、麻醉组(Ane组)、假手术组(Sham组)和手术组(Sur组)4组(n均为24)。使用Morris水迷宫进行认知功能测试。测试完毕后,采用Western blot和Real Time RT-PCR检测海马IL-1β、IL-6、TNF-α蛋白及mRNA表达水平。结果:术后第1、3、7天,4组动物目标象限停留时间百分比及1min内穿台次数差异有统计学意义(P均<0.05),且Sur组低于其他3组;4组动物海马IL-1β、IL-6、TNF-α蛋白及mRNA的表达差异有统计学意义(P均<0.001),Sur组较其他3组表达上调。结论:手术创伤能够引起老年小鼠术后认知功能障碍,其机制可能与术后海马组织中IL-1β、IL-6及TNF-α的表达上调有关。
