Colorectal cancer (CRC) is still one of the leading causes of cancer-related death in Western countries, despite major improvements in its treatment. The dramatically high social and economic impact of CRC on human he...Colorectal cancer (CRC) is still one of the leading causes of cancer-related death in Western countries, despite major improvements in its treatment. The dramatically high social and economic impact of CRC on human health makes the identification of a reliable screening tool of paramount importance. Current screening methods, such as the fecal occult blood test and colonoscopy do not adequately meet the ideal requisites of a screening test because, even if they are effective, they are limited first by too low specificity and sensitivity, or second by high invasiveness, costs and risk. Nowadays extended efforts are made by researchers to look for more reliable and effective screening tests based on a systems biology approach, using biological samples easily available, such as urine, breath, serum and feces. The effectiveness and reliability of several new attempts to screen these patients by non-invasive analysis of their biological samples using genomic (genetic and epigenetic alteration), transcriptomic (miRNA), proteomic (cancer-related antigens, new antibodies against tumor-associated antigens, mutated proteins) and metabolomic (volatile organic metabolites) methods are discussed in this review. Among the most interesting new screening tools, fecal fluorescent long-DNA, fecal miRNA and metabolomic evaluation in breath and/ or serum seem to be most promising.展开更多
An improved 2 D stability margin test and its algorithm for 2 D discrete systems are proposed.The stability margin test procedure can be slmplified by using the inner term polynomials of B(z 1,z 2) to construct a ma...An improved 2 D stability margin test and its algorithm for 2 D discrete systems are proposed.The stability margin test procedure can be slmplified by using the inner term polynomials of B(z 1,z 2) to construct a margin test table.Different from other well known 2 D stability margin test algorithms,the new approach can directly obtain the stability margin.展开更多
The benchmark test system for distribution systems is necessary and important for system analysis and result data checking.In order to meet the development demand of the distribution systems which integrate with a hig...The benchmark test system for distribution systems is necessary and important for system analysis and result data checking.In order to meet the development demand of the distribution systems which integrate with a high penetration of distributed generation(DG),a benchmark test system for the distribution systems which adapts to current and future development trends is proposed.Based on the concentric zone theory and the typical regional settlement model in China,three typical distribution system scenarios corresponding to different system circle structures and regional development characteristics are designed in this paper.In order to adapt to the trend that the distribution systems will present the mixed state of AC and DC,a typical improvement scheme of distribution systems in urban scenario is presented.The benchmark test system of low-voltage distribution systems in a rural scenario is also designed because of the high penetration of DG.Moreover,the system structure,load parameters,integrated capacity and output characteristics of varies types of DG in different scenarios are described in detail.Finally,the simulation results,such as the time series power flow,reliability evaluation and hosting capacity of DGs are given.The benchmark test system proposed in this paper will lay a foundation for future research on distribution systems with a high proportion of DG and effectively support the distribution systems planning,design,operations and dispatches.展开更多
介绍了一种便携式探针台,其结构小巧,功能实用,成本较低,可以满足基本的试验需求。特别之处在于显微镜和探针台采用分体结构设计,使得探针台部分能从整个探针台系统中独立出来,可以应用于辐照试验中。固定在探针台上的芯片可以与探针台...介绍了一种便携式探针台,其结构小巧,功能实用,成本较低,可以满足基本的试验需求。特别之处在于显微镜和探针台采用分体结构设计,使得探针台部分能从整个探针台系统中独立出来,可以应用于辐照试验中。固定在探针台上的芯片可以与探针台一起放置于空间任意位置,方便将芯片对准辐照源中心。该探针台也可放置在高低温箱中,用于芯片的三温测试。加上显微镜固定采用多角度云台支架设计,支持全方位观察,可以使得观察更加立体直观。探针卡采用多探针结构,可实现多路测试,并且探卡及其信号连接线采用了低漏电及EMI设计,测试精度可以达到0.1 n A以下,配合接地良好的铝制屏蔽盒,增加了抗干扰能力,其测试数据更加精确。展开更多
To explore the low-speed characteristics of the Blended-Wing-Body(BWB)configuration for future civil aircraft,a series of unmanned subscale demonstrators have been developed and tested by our research team.During thi...To explore the low-speed characteristics of the Blended-Wing-Body(BWB)configuration for future civil aircraft,a series of unmanned subscale demonstrators have been developed and tested by our research team.During this process,specific safety risks deriving from uncertain design features,system unreliability,and insufficient personnel experience caused continuous flight test mishaps and the risk mechanism was not clear.Local and trial-and-error learning driven safety improvements took few effects on mishap prevention,so our focus was turned to look for systematic safety strategies.This paper establishes a systems theory based hybrid model to integrate the physical system reliability analysis techniques with the system dynamics method for illustrating the multiple risk interactions of the demonstrator flight test involving organizational,human resource and technical system factors.Using the prior BB-5 demonstrator as a case,the hybrid model simulation represents its historical risk evolution process,which verifies the model rationality.Derived risk control strategies reduced the mishap rate of a new demonstrator called BB-6 Sprit.The paper also shows the extended hybrid model can be applied on safety management of unmanned aerial vehicles from the initial period of vehicle development.展开更多
文摘Colorectal cancer (CRC) is still one of the leading causes of cancer-related death in Western countries, despite major improvements in its treatment. The dramatically high social and economic impact of CRC on human health makes the identification of a reliable screening tool of paramount importance. Current screening methods, such as the fecal occult blood test and colonoscopy do not adequately meet the ideal requisites of a screening test because, even if they are effective, they are limited first by too low specificity and sensitivity, or second by high invasiveness, costs and risk. Nowadays extended efforts are made by researchers to look for more reliable and effective screening tests based on a systems biology approach, using biological samples easily available, such as urine, breath, serum and feces. The effectiveness and reliability of several new attempts to screen these patients by non-invasive analysis of their biological samples using genomic (genetic and epigenetic alteration), transcriptomic (miRNA), proteomic (cancer-related antigens, new antibodies against tumor-associated antigens, mutated proteins) and metabolomic (volatile organic metabolites) methods are discussed in this review. Among the most interesting new screening tools, fecal fluorescent long-DNA, fecal miRNA and metabolomic evaluation in breath and/ or serum seem to be most promising.
文摘An improved 2 D stability margin test and its algorithm for 2 D discrete systems are proposed.The stability margin test procedure can be slmplified by using the inner term polynomials of B(z 1,z 2) to construct a margin test table.Different from other well known 2 D stability margin test algorithms,the new approach can directly obtain the stability margin.
基金supported in part by the National Key Research and Development Program of China under Grant 2016YFB0900100in part by the National Natural Science Foundation of China under Grant 51977140,Grant U1866207in part by the Natural Science Foundation of Tianjin under Grant 19JCYBJC21300.
文摘The benchmark test system for distribution systems is necessary and important for system analysis and result data checking.In order to meet the development demand of the distribution systems which integrate with a high penetration of distributed generation(DG),a benchmark test system for the distribution systems which adapts to current and future development trends is proposed.Based on the concentric zone theory and the typical regional settlement model in China,three typical distribution system scenarios corresponding to different system circle structures and regional development characteristics are designed in this paper.In order to adapt to the trend that the distribution systems will present the mixed state of AC and DC,a typical improvement scheme of distribution systems in urban scenario is presented.The benchmark test system of low-voltage distribution systems in a rural scenario is also designed because of the high penetration of DG.Moreover,the system structure,load parameters,integrated capacity and output characteristics of varies types of DG in different scenarios are described in detail.Finally,the simulation results,such as the time series power flow,reliability evaluation and hosting capacity of DGs are given.The benchmark test system proposed in this paper will lay a foundation for future research on distribution systems with a high proportion of DG and effectively support the distribution systems planning,design,operations and dispatches.
文摘介绍了一种便携式探针台,其结构小巧,功能实用,成本较低,可以满足基本的试验需求。特别之处在于显微镜和探针台采用分体结构设计,使得探针台部分能从整个探针台系统中独立出来,可以应用于辐照试验中。固定在探针台上的芯片可以与探针台一起放置于空间任意位置,方便将芯片对准辐照源中心。该探针台也可放置在高低温箱中,用于芯片的三温测试。加上显微镜固定采用多角度云台支架设计,支持全方位观察,可以使得观察更加立体直观。探针卡采用多探针结构,可实现多路测试,并且探卡及其信号连接线采用了低漏电及EMI设计,测试精度可以达到0.1 n A以下,配合接地良好的铝制屏蔽盒,增加了抗干扰能力,其测试数据更加精确。
基金sponsored by the National Natural Science Foundation of China (No. 61803263)the Startup Fund for Youngman Research at SJTU of China (SFYR at SJTU)
文摘To explore the low-speed characteristics of the Blended-Wing-Body(BWB)configuration for future civil aircraft,a series of unmanned subscale demonstrators have been developed and tested by our research team.During this process,specific safety risks deriving from uncertain design features,system unreliability,and insufficient personnel experience caused continuous flight test mishaps and the risk mechanism was not clear.Local and trial-and-error learning driven safety improvements took few effects on mishap prevention,so our focus was turned to look for systematic safety strategies.This paper establishes a systems theory based hybrid model to integrate the physical system reliability analysis techniques with the system dynamics method for illustrating the multiple risk interactions of the demonstrator flight test involving organizational,human resource and technical system factors.Using the prior BB-5 demonstrator as a case,the hybrid model simulation represents its historical risk evolution process,which verifies the model rationality.Derived risk control strategies reduced the mishap rate of a new demonstrator called BB-6 Sprit.The paper also shows the extended hybrid model can be applied on safety management of unmanned aerial vehicles from the initial period of vehicle development.
