Primary central nervous system lymphoma(PCNSL)is an uncommon non-Hodgkin’s lymphoma with poor prognosis.This study aimed to depict the genetic landscape of Chinese PCNSLs.Whole-genome sequencing was performed on 68 n...Primary central nervous system lymphoma(PCNSL)is an uncommon non-Hodgkin’s lymphoma with poor prognosis.This study aimed to depict the genetic landscape of Chinese PCNSLs.Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples,whose genomic characteristics and clinicopathologic features were also analyzed.Structural variations were identified in all patients with a mean of 349,which did not significantly influence prognosis.Copy loss occurred in all samples,while gains were detected in 77.9%of the samples.The high level of copy number variations was significantly associated with poor progression-free survival(PFS)and overall survival(OS).A total of 263 genes mutated in coding regions were identified,including 6 newly discovered genes(ROBO2,KMT2C,CXCR4,MYOM2,BCLAF1,and NRXN3)detected in≥10%of the cases.CD79B mutation was significantly associated with lower PFS,TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS.A prognostic risk scoring system was also established for PCNSL,which included Karnofsky performance status and six mutated genes(BRD4,EBF1,BTG1,CCND3,STAG2,and TMSB4X).Collectively,this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs,thereby enriching the present understanding of the genetic mechanisms of PCNSL.展开更多
CC-DOS 4.0 assimilates virtues of the previous version and quickens the processing speed by 50 per cent. To comprehend its confidential mystery would help grasp its implementation principles and methods. This paper sh...CC-DOS 4.0 assimilates virtues of the previous version and quickens the processing speed by 50 per cent. To comprehend its confidential mystery would help grasp its implementation principles and methods. This paper shall introduce CC-DOS 4.0 bootstrap which is the base of a comprehensive analysis of CC-DOS 4.0.展开更多
With the digital information and application requirement on the Internet increasing fleetly nowadays,it is urgent to work out a network storage system with a large capacity,a high availability and scalability.To solve...With the digital information and application requirement on the Internet increasing fleetly nowadays,it is urgent to work out a network storage system with a large capacity,a high availability and scalability.To solve the above-mentioned issues,a NAS-based storage network(for short NASSN)has been designed.Firstly,the NASSN integrates multi-NAS,iNAS(an iSCSI-based NAS)and enterprise SAN with the help of storage virtualization,which can provide a greater capacity and better scalability.Secondly,the NASSN can provide high availability with the help of server and storage subsystem redundancy technologies.Thirdly,the NASSN simultaneously serves for both the file I/O and the block I/O with the help of an iSCSI module,which has the advantages of NAS and SAN.Finally,the NASSN can provide higher I/O speed by a high network-attached channel which implements the direct data transfer between the storage device and client.In the experiments,the NASSN has ultra-high-throughput for both of the file I/O requests and the block I/O requests.展开更多
基金supported by funds from the Translational Research Grant of National Clinical Research Center for Hematologic Disease (No.2020ZKZC01)the National Natural Science Foundation of China (Nos.81830006,82170219,and 81800188)the Lymphoma Research Fund of China Anti-Cancer Association.
文摘Primary central nervous system lymphoma(PCNSL)is an uncommon non-Hodgkin’s lymphoma with poor prognosis.This study aimed to depict the genetic landscape of Chinese PCNSLs.Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples,whose genomic characteristics and clinicopathologic features were also analyzed.Structural variations were identified in all patients with a mean of 349,which did not significantly influence prognosis.Copy loss occurred in all samples,while gains were detected in 77.9%of the samples.The high level of copy number variations was significantly associated with poor progression-free survival(PFS)and overall survival(OS).A total of 263 genes mutated in coding regions were identified,including 6 newly discovered genes(ROBO2,KMT2C,CXCR4,MYOM2,BCLAF1,and NRXN3)detected in≥10%of the cases.CD79B mutation was significantly associated with lower PFS,TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS.A prognostic risk scoring system was also established for PCNSL,which included Karnofsky performance status and six mutated genes(BRD4,EBF1,BTG1,CCND3,STAG2,and TMSB4X).Collectively,this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs,thereby enriching the present understanding of the genetic mechanisms of PCNSL.
文摘CC-DOS 4.0 assimilates virtues of the previous version and quickens the processing speed by 50 per cent. To comprehend its confidential mystery would help grasp its implementation principles and methods. This paper shall introduce CC-DOS 4.0 bootstrap which is the base of a comprehensive analysis of CC-DOS 4.0.
基金Sponsored by the National Natural Science Foundation of China(Grant No.60673191and90304011)Science Innovation Term Foundation of Guang-dong University of Foreign Studies(Grant No.GW2006-AT-005)Science Innovation Term Foundation of School of Informatics Guangdong University of Foreign Studies.
文摘With the digital information and application requirement on the Internet increasing fleetly nowadays,it is urgent to work out a network storage system with a large capacity,a high availability and scalability.To solve the above-mentioned issues,a NAS-based storage network(for short NASSN)has been designed.Firstly,the NASSN integrates multi-NAS,iNAS(an iSCSI-based NAS)and enterprise SAN with the help of storage virtualization,which can provide a greater capacity and better scalability.Secondly,the NASSN can provide high availability with the help of server and storage subsystem redundancy technologies.Thirdly,the NASSN simultaneously serves for both the file I/O and the block I/O with the help of an iSCSI module,which has the advantages of NAS and SAN.Finally,the NASSN can provide higher I/O speed by a high network-attached channel which implements the direct data transfer between the storage device and client.In the experiments,the NASSN has ultra-high-throughput for both of the file I/O requests and the block I/O requests.
