Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of biomedic...Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of biomedicine.However,green and facile synthesis of hierarchically porous nanomaterials with beneficial water dispersibility and biocompatibility is still a great challenge.Herein,a novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled HPCaCO_(3)/CaF_(2) hollow nanospheres under the mediation of yeast cells.The biomolecules derived from the secretion of yeast cells are used as conditioning and stabilizing agents to control the biosynthesis of the HPCaCO_(3)/CaF_(2) materials,which exhibit excellent water dispersibility and favorable biocompatibility.The double-shelled CaCO_(3)/CaF_(2) nanospheres hold hierarchically porous structure and have abundant pore channel and large specific surface area,showing high drug-loading and a prolonged drug sustainable release profile by the pore-by-pore diffusion pattern of the hierarchical pores.Otherwise,the HPCaCO_(3) with pH-sensitivity could controllably release drug doxorubicin hydrochloride(DOX)at the acidic tumor microenvironment.Both in vitro and in vivo results demonstrate that HPCaCO_(3)/CaF_(2) has the sustainable pH-sensitive drug release property,showing an enhanced therapeutic effect.Summarily,this study provides a biomimetic strategy to synthesize the hierarchically porous double-shelled hollow nanomaterials for applying in sustainable drug delivery system.展开更多
Compounds 1 （C15H17C1F3N303, Mr = 379） and 2 （C14H14C1F3N4OS, Mr = 378） have been synthesized and their crystal structures were determined by single-crystal X-ray diffraction. Crystal 1 belongs to the triclinic sy...Compounds 1 （C15H17C1F3N303, Mr = 379） and 2 （C14H14C1F3N4OS, Mr = 378） have been synthesized and their crystal structures were determined by single-crystal X-ray diffraction. Crystal 1 belongs to the triclinic system, space group P1 with a = 6.0223（19）, b = 9.324（3）, c = 15.936（5） A, a = 80.687（5）, β= 87.289（5）, ）, = 86.097（5）°, V= 880.4（5） A3, Z = 2, Dc = 1.433 g/cm3,μ（MoKa） = 0.266 mm^-1, F（000） = 392, R = 0.0861 and wR = 0.1999 for 2022 observed reflections with I 〉 2o（/）. Crystal 2 belongs to the triclinic system, space group PI with a = 7.7029（15）, b = 8.3371（16）, c = 14.410（3） A, a = 100.672（3）, β= 103.168（3）, ？ = 98.726（3）°, V = 876.1（3） A3, Z = 2, Dc= 1.451 g/cm^3,μ（MoKa） = 0.379 mm^-1, F（000） = 388, R = 0.0672 and wR = 0.2105 for 2725 observed reflections with I 〉 2σ（I）. Although the two compounds are similar with the same pyrazole and pyrethroid units, X-ray analysis reveals that their structures are completely different.展开更多
The crystal and molecular structures of the K[Tb^(III)(edta)(H_2O)_3].5 H_2O(edta = ethylenediaminetetraacetic acid) and K_4[Tb^(III)_2(Httha)_2].14 H_2O (ttha =triethylenetetraminehexaacetic acid) complexes have been...The crystal and molecular structures of the K[Tb^(III)(edta)(H_2O)_3].5 H_2O(edta = ethylenediaminetetraacetic acid) and K_4[Tb^(III)_2(Httha)_2].14 H_2O (ttha =triethylenetetraminehexaacetic acid) complexes have been determined by single-crystal X-raydiffraction analyses. The crystal of the K[Tb^(III)(edta)(H_2O)_3].5 H_2O complex belongs toorthorhombic crystal system and Fdd 2 space group. The crystal data are as follows: a = 1.9373(5)nm, b = 3.5429(10) nm, c = 1.2114(3) nm, V 8.315(4) nm^3, Z= 16, M= 630.35, Dc = 2.014 g cm^(-3), m= 3.683 mm^(-1) and F(000) = 5024. The final Rand wR values are 0.0224 and 0.0557 for 3189 [I> 2.0sigma(I)] unique reflections, and 0.0245 and 0.0567 for all 8206 reflections, respectively. The[Tb^(III)(edta)(H_2O)_3]^- complex anion has a nine-coordinated pseudo-monocapped squareantiprismatic structure in which the nine coordinate atoms, two N and seven O come from one edtaligand and three water molecules. The crystal of the K_4[Tb^(III)_2(Httha)_2].14 H_2O complexbelongs to monoclinic system and P 2(1)/n space group. The crystal data are as follows: a =1.1326(3) nm, b = 2.5675(7) nm, C =2.2076(6) nm, bate = 102.943(5) centre dot, V =6.256(3) nm^3, Z =4, M = 1705.26, Dc = 1.802 g cm^(-3), m = 2.611 mm^(-1) and F(000) = 3424. The final R and wR are0.0339 and 0.0667 for 10699 [I>2.0 sigma (I)] unique reflections, and 0.0543 and 0.0741 for all22190 reflections, respectively. The total complex molecule is composed of two close parts instructure.展开更多
The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of micro...The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of microwave technology. Elemental analyses, electrical conductance, magnetic moment and electronic, infrared, far-infrared, 1H and 13C NMR spectral studies were used to characterize the complexes. The molecular weights of few complexes were determined by FAB-mass spectra. Nephelauxetic ratio, covalency parameter and bonding parameter for these complexes were also calculated. The probable structures of the complexes were proposed. The antifungal and antibacterial activities of the complexes were evaluated. The activities were correlated with the structures of the compounds.展开更多
Macroreticular bead PAN/PVC IPN resins with cyano and chloro groups were synthesized by interpenetrating polymerization of acrylonitrile, or acrylonitrile and divinylbenzene into a macroporous polyvinyl chloride bead....Macroreticular bead PAN/PVC IPN resins with cyano and chloro groups were synthesized by interpenetrating polymerization of acrylonitrile, or acrylonitrile and divinylbenzene into a macroporous polyvinyl chloride bead. The composition and structure of the bead IPN resins have been investigated by means of FT-IR, NMR, SEM, mercury porosimetry and elemental analysis. During the process of interpenetrating polymerization, the chain propagation obeys Bernoullian statistical law, and no grafting polymerization has been observed. The content of cyano group in the resulting IPN resins can be adjusted by the amount of acrylonitrile added. The morphology of the IPN resins basically resembles that of the polyvinyl chloride bead, whereas the pore structures vary to a certain degree展开更多
基金financially supported by the Natural Science Foundation of Henan Province of China(Key Program,No.242300421205)the National Natural Science Foundation of China(21877027,21771058,and 21601052)+3 种基金Key Science and Technology Project of Henan Province(232102310223)Program for Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTITO02)Natural Science Foundation of Henan(212300410009)the Program for Innovative Research Team in Science and Technology in Universities of Henan Province(19IRTSTHNO23).
文摘Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of biomedicine.However,green and facile synthesis of hierarchically porous nanomaterials with beneficial water dispersibility and biocompatibility is still a great challenge.Herein,a novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled HPCaCO_(3)/CaF_(2) hollow nanospheres under the mediation of yeast cells.The biomolecules derived from the secretion of yeast cells are used as conditioning and stabilizing agents to control the biosynthesis of the HPCaCO_(3)/CaF_(2) materials,which exhibit excellent water dispersibility and favorable biocompatibility.The double-shelled CaCO_(3)/CaF_(2) nanospheres hold hierarchically porous structure and have abundant pore channel and large specific surface area,showing high drug-loading and a prolonged drug sustainable release profile by the pore-by-pore diffusion pattern of the hierarchical pores.Otherwise,the HPCaCO_(3) with pH-sensitivity could controllably release drug doxorubicin hydrochloride(DOX)at the acidic tumor microenvironment.Both in vitro and in vivo results demonstrate that HPCaCO_(3)/CaF_(2) has the sustainable pH-sensitive drug release property,showing an enhanced therapeutic effect.Summarily,this study provides a biomimetic strategy to synthesize the hierarchically porous double-shelled hollow nanomaterials for applying in sustainable drug delivery system.
基金supported by Hubei University of Technology,Science and Technology Department of Hubei Province(No.ZRY0981)National Natural Science Foundation of China(No.21272086)
文摘Compounds 1 （C15H17C1F3N303, Mr = 379） and 2 （C14H14C1F3N4OS, Mr = 378） have been synthesized and their crystal structures were determined by single-crystal X-ray diffraction. Crystal 1 belongs to the triclinic system, space group P1 with a = 6.0223（19）, b = 9.324（3）, c = 15.936（5） A, a = 80.687（5）, β= 87.289（5）, ）, = 86.097（5）°, V= 880.4（5） A3, Z = 2, Dc = 1.433 g/cm3,μ（MoKa） = 0.266 mm^-1, F（000） = 392, R = 0.0861 and wR = 0.1999 for 2022 observed reflections with I 〉 2o（/）. Crystal 2 belongs to the triclinic system, space group PI with a = 7.7029（15）, b = 8.3371（16）, c = 14.410（3） A, a = 100.672（3）, β= 103.168（3）, ？ = 98.726（3）°, V = 876.1（3） A3, Z = 2, Dc= 1.451 g/cm^3,μ（MoKa） = 0.379 mm^-1, F（000） = 388, R = 0.0672 and wR = 0.2105 for 2725 observed reflections with I 〉 2σ（I）. Although the two compounds are similar with the same pyrazole and pyrethroid units, X-ray analysis reveals that their structures are completely different.
文摘The crystal and molecular structures of the K[Tb^(III)(edta)(H_2O)_3].5 H_2O(edta = ethylenediaminetetraacetic acid) and K_4[Tb^(III)_2(Httha)_2].14 H_2O (ttha =triethylenetetraminehexaacetic acid) complexes have been determined by single-crystal X-raydiffraction analyses. The crystal of the K[Tb^(III)(edta)(H_2O)_3].5 H_2O complex belongs toorthorhombic crystal system and Fdd 2 space group. The crystal data are as follows: a = 1.9373(5)nm, b = 3.5429(10) nm, c = 1.2114(3) nm, V 8.315(4) nm^3, Z= 16, M= 630.35, Dc = 2.014 g cm^(-3), m= 3.683 mm^(-1) and F(000) = 5024. The final Rand wR values are 0.0224 and 0.0557 for 3189 [I> 2.0sigma(I)] unique reflections, and 0.0245 and 0.0567 for all 8206 reflections, respectively. The[Tb^(III)(edta)(H_2O)_3]^- complex anion has a nine-coordinated pseudo-monocapped squareantiprismatic structure in which the nine coordinate atoms, two N and seven O come from one edtaligand and three water molecules. The crystal of the K_4[Tb^(III)_2(Httha)_2].14 H_2O complexbelongs to monoclinic system and P 2(1)/n space group. The crystal data are as follows: a =1.1326(3) nm, b = 2.5675(7) nm, C =2.2076(6) nm, bate = 102.943(5) centre dot, V =6.256(3) nm^3, Z =4, M = 1705.26, Dc = 1.802 g cm^(-3), m = 2.611 mm^(-1) and F(000) = 3424. The final R and wR are0.0339 and 0.0667 for 10699 [I>2.0 sigma (I)] unique reflections, and 0.0543 and 0.0741 for all22190 reflections, respectively. The total complex molecule is composed of two close parts instructure.
文摘The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of microwave technology. Elemental analyses, electrical conductance, magnetic moment and electronic, infrared, far-infrared, 1H and 13C NMR spectral studies were used to characterize the complexes. The molecular weights of few complexes were determined by FAB-mass spectra. Nephelauxetic ratio, covalency parameter and bonding parameter for these complexes were also calculated. The probable structures of the complexes were proposed. The antifungal and antibacterial activities of the complexes were evaluated. The activities were correlated with the structures of the compounds.
基金Supported by the Science Fund of the State Education Commission of China.
文摘Macroreticular bead PAN/PVC IPN resins with cyano and chloro groups were synthesized by interpenetrating polymerization of acrylonitrile, or acrylonitrile and divinylbenzene into a macroporous polyvinyl chloride bead. The composition and structure of the bead IPN resins have been investigated by means of FT-IR, NMR, SEM, mercury porosimetry and elemental analysis. During the process of interpenetrating polymerization, the chain propagation obeys Bernoullian statistical law, and no grafting polymerization has been observed. The content of cyano group in the resulting IPN resins can be adjusted by the amount of acrylonitrile added. The morphology of the IPN resins basically resembles that of the polyvinyl chloride bead, whereas the pore structures vary to a certain degree
