Background：The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery Score Ⅱ （SS-Ⅱ） can well predict 4-year mortality in patients with complex coronary artery disease （CAD）,and guide...Background：The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery Score Ⅱ （SS-Ⅱ） can well predict 4-year mortality in patients with complex coronary artery disease （CAD）,and guide decision-making between coronary artery bypass graft surgery and percutaneous coronary intervention （PCI）.However,there is lack of data regarding the utility of the SS-Ⅱ in patients with three-vessel CAD undergoing PCI treated with second-generation drug-eluting stents （DES）.The purpose of the present study was to evaluate the ability of the SS-Ⅱ to predict long-term mortality in patients with three-vessel CAD undergoing PCI with second-generation DES.Methods：Totally,573 consecutive patients with de novo three-vessel CAD who underwent PCI with second-generation DES were retrospectively studied.According to the tertiles of the SS-Ⅱ,the patients were divided into three groups：The lowest SS-Ⅱ tertile （SS-Ⅱ ≤20）,intermediate SS-Ⅱ tertile （SS-Ⅱ of 21-31）,and the highest SS-Ⅱ tertile （SS-Ⅱ ≥32）.The survival curves of the different groups were estimated by the Kaplan-Meier method.Univariate and multivariate Cox proportional hazard regression analyses were performed to evaluate the relationship between the SS-Ⅱ and 5-year mortality.The performance of the SS-Ⅱ with respect to predicting the rate of mortality was studied by calculating the area under the receiver operator characteristic （ROC） curve.The predictive ability of the SS-Ⅱ for 5-year mortality was evaluated and compared with the SS alone.Results：The overall SS-Ⅱ was 27.6 ± 9.0.Among patients in the lowest,intermediate and the highest SS-Ⅱ tertiles,the 5-year rates of mortality were 1.6%,3.2%,and 8.6%,respectively （P =0.003）;the cardiac mortality rates were 0.5%,1.9%,and 5.2%,respectively （P =0.014）.By multivariable analysis,adjusting for the potential confounders,the SS-Ⅱ was an independent predictor of 5-year mortality （hazard ratio：2.45,95% confidence interval：1.展开更多
近年来,自主无人系统的开发成本随着硬件设备性能的提高而增加,如何高效、智能化地完成开发工作成为无人系统的热门研究领域。基于AADL(Architecture Analysis and Design Language)的自主无人系统可成长框架从系统架构方式、基于配置...近年来,自主无人系统的开发成本随着硬件设备性能的提高而增加,如何高效、智能化地完成开发工作成为无人系统的热门研究领域。基于AADL(Architecture Analysis and Design Language)的自主无人系统可成长框架从系统架构方式、基于配置项的系统工作模式以及原型系统等方面实现了无人系统(无人机、无人车等)软件适应性方案,以支撑资源、任务、环境变化时无人系统软件的成长和演化。搭建系统框架时采用基于模型驱动的思想,使用AADL模型基表示系统的中间组件,既保留了组件之间的继承关系,又便于开发者更直观地观察系统结构。系统模块化是实现其可成长性的基础,通过统一规范接口书写规则的方式,AADL模型基将可替换算法封装在中间组件中,算法的迭代与进化映射出了系统的可持续演化过程。通过爬虫的方式建立一个不断扩展的系统组件库,组件库除了支持自适应扩展功能外,还支持自定义模型的基功能。系统框架的可成长特性除了表现在系统文件的内容可扩展外,还表现在系统配置方案的选择多样性。在不同的环境、任务、资源状况下,系统的最佳配置项方案可能不同,为了找出适应条件的无人系统配置项选项的最优解,采用进化算法的思想,使系统实现自主进化的过程。最后,利用代码自动生成技术,实现AADL模型到系统文件之间的转换。通过可成长软件管理平台的运行与测试,验证了自主无人系统可成长框架的可行性。展开更多
文摘Background：The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery Score Ⅱ （SS-Ⅱ） can well predict 4-year mortality in patients with complex coronary artery disease （CAD）,and guide decision-making between coronary artery bypass graft surgery and percutaneous coronary intervention （PCI）.However,there is lack of data regarding the utility of the SS-Ⅱ in patients with three-vessel CAD undergoing PCI treated with second-generation drug-eluting stents （DES）.The purpose of the present study was to evaluate the ability of the SS-Ⅱ to predict long-term mortality in patients with three-vessel CAD undergoing PCI with second-generation DES.Methods：Totally,573 consecutive patients with de novo three-vessel CAD who underwent PCI with second-generation DES were retrospectively studied.According to the tertiles of the SS-Ⅱ,the patients were divided into three groups：The lowest SS-Ⅱ tertile （SS-Ⅱ ≤20）,intermediate SS-Ⅱ tertile （SS-Ⅱ of 21-31）,and the highest SS-Ⅱ tertile （SS-Ⅱ ≥32）.The survival curves of the different groups were estimated by the Kaplan-Meier method.Univariate and multivariate Cox proportional hazard regression analyses were performed to evaluate the relationship between the SS-Ⅱ and 5-year mortality.The performance of the SS-Ⅱ with respect to predicting the rate of mortality was studied by calculating the area under the receiver operator characteristic （ROC） curve.The predictive ability of the SS-Ⅱ for 5-year mortality was evaluated and compared with the SS alone.Results：The overall SS-Ⅱ was 27.6 ± 9.0.Among patients in the lowest,intermediate and the highest SS-Ⅱ tertiles,the 5-year rates of mortality were 1.6%,3.2%,and 8.6%,respectively （P =0.003）;the cardiac mortality rates were 0.5%,1.9%,and 5.2%,respectively （P =0.014）.By multivariable analysis,adjusting for the potential confounders,the SS-Ⅱ was an independent predictor of 5-year mortality （hazard ratio：2.45,95% confidence interval：1.
文摘近年来,自主无人系统的开发成本随着硬件设备性能的提高而增加,如何高效、智能化地完成开发工作成为无人系统的热门研究领域。基于AADL(Architecture Analysis and Design Language)的自主无人系统可成长框架从系统架构方式、基于配置项的系统工作模式以及原型系统等方面实现了无人系统(无人机、无人车等)软件适应性方案,以支撑资源、任务、环境变化时无人系统软件的成长和演化。搭建系统框架时采用基于模型驱动的思想,使用AADL模型基表示系统的中间组件,既保留了组件之间的继承关系,又便于开发者更直观地观察系统结构。系统模块化是实现其可成长性的基础,通过统一规范接口书写规则的方式,AADL模型基将可替换算法封装在中间组件中,算法的迭代与进化映射出了系统的可持续演化过程。通过爬虫的方式建立一个不断扩展的系统组件库,组件库除了支持自适应扩展功能外,还支持自定义模型的基功能。系统框架的可成长特性除了表现在系统文件的内容可扩展外,还表现在系统配置方案的选择多样性。在不同的环境、任务、资源状况下,系统的最佳配置项方案可能不同,为了找出适应条件的无人系统配置项选项的最优解,采用进化算法的思想,使系统实现自主进化的过程。最后,利用代码自动生成技术,实现AADL模型到系统文件之间的转换。通过可成长软件管理平台的运行与测试,验证了自主无人系统可成长框架的可行性。
