目的:揭示诊断时运动单位估数(motor unit number estimate,MUNE)的线性变化率与生存时间的相关性。方法:收集2002年1月至2005年12月肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)患者129例,全部患者记录临床资料、用力肺活量(for...目的:揭示诊断时运动单位估数(motor unit number estimate,MUNE)的线性变化率与生存时间的相关性。方法:收集2002年1月至2005年12月肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)患者129例,全部患者记录临床资料、用力肺活量(forced vital capacity,FVC)、电生理指标和神经功能等级评分(ALS functional rating scale,ALSFRS),每3个月对患者进行1次面访或电话随访,直至终点事件(死亡或进行气管切开)。结果:患者的平均发病年龄为(52.19±11.00)岁,中位生存时间为45.71个月(95的可信区间为35～51个月)。用Kaplan-Meier单因素分析方法,发现MUNE的线性变化率是影响生存时间的重要因素(P<0.05)。进一步用Cox风险比例模型分析,MUNE的线性变化率为生存时间的重要预后因子(P<0.01)。用2.9/月作为分界点,诊断时MUNE线性变化率超过此值的生存时间较短,反之较长(P<0.05),其下降一个单位,死亡风险下降34.2。结论:基于MUNE的线性估测方法可以从疾病进展的某一点判断病情,从而将患者分层,有力地影响生存时间。MUNE的线性估测值是较年龄、起病部位、确诊时间更为重要的影响生存时间的因素。展开更多
The analysis of survival data is a major focus of statistics. Interval censored data reflect uncertainty as to the exact times the units failed within an interval. This type of data frequently comes from tests or situ...The analysis of survival data is a major focus of statistics. Interval censored data reflect uncertainty as to the exact times the units failed within an interval. This type of data frequently comes from tests or situations where the objects of interest are not constantly monitored. Thus events are known only to have occurred between the two observation periods. Interval censoring has become increasingly common in the areas that produce failure time data. This paper explores the statistical analysis of interval-censored failure time data with applications. Three different data sets, namely Breast Cancer, Hemophilia, and AIDS data were used to illustrate the methods during this study. Both parametric and nonparametric methods of analysis are carried out in this study. Theory and methodology of fitted models for the interval-censored data are described. Fitting of parametric and non-parametric models to three real data sets are considered. Results derived from different methods are presented and also compared.展开更多
Types of hybrid architectures survivor memory unit (SMU) is presented,which are applicable to IEEE 802.3 ab 1000 Base-T Gigabit Ethernet (GbE) transceiver. Area, power and decoder latency were taken into account and m...Types of hybrid architectures survivor memory unit (SMU) is presented,which are applicable to IEEE 802.3 ab 1000 Base-T Gigabit Ethernet (GbE) transceiver. Area, power and decoder latency were taken into account and most efficient architectures were compared to optimize area/power tradeoff in different kinds of applications. Suitable SMU architectures are given out respectively in area-restrict, power-restrict and latency-restrict designs. A power-efficient architecture was selected in our GbE project. It provides 48% improvement in area and 71% amelioration in power, compared to classical register exchange architecture (REA) SMU.展开更多
文摘The analysis of survival data is a major focus of statistics. Interval censored data reflect uncertainty as to the exact times the units failed within an interval. This type of data frequently comes from tests or situations where the objects of interest are not constantly monitored. Thus events are known only to have occurred between the two observation periods. Interval censoring has become increasingly common in the areas that produce failure time data. This paper explores the statistical analysis of interval-censored failure time data with applications. Three different data sets, namely Breast Cancer, Hemophilia, and AIDS data were used to illustrate the methods during this study. Both parametric and nonparametric methods of analysis are carried out in this study. Theory and methodology of fitted models for the interval-censored data are described. Fitting of parametric and non-parametric models to three real data sets are considered. Results derived from different methods are presented and also compared.
基金National Science Fund for Creative ResearchGroups (No.60521002)Shanghai NaturalScience Foundation(No.037062022)
文摘Types of hybrid architectures survivor memory unit (SMU) is presented,which are applicable to IEEE 802.3 ab 1000 Base-T Gigabit Ethernet (GbE) transceiver. Area, power and decoder latency were taken into account and most efficient architectures were compared to optimize area/power tradeoff in different kinds of applications. Suitable SMU architectures are given out respectively in area-restrict, power-restrict and latency-restrict designs. A power-efficient architecture was selected in our GbE project. It provides 48% improvement in area and 71% amelioration in power, compared to classical register exchange architecture (REA) SMU.
基金partially supported by National Natural Science Foundation of China(10471136,10971210)the Knowledge Innovation Program of the Chinese Academy of Sciences(KJCX3-SYW-S02)
