Complicated geological structures make it difficult to analyze the stability of rock slopes, such as faults, weak intercalated layers or joint fissures. Based on 3D geological modeling and surface block identifying me...Complicated geological structures make it difficult to analyze the stability of rock slopes, such as faults, weak intercalated layers or joint fissures. Based on 3D geological modeling and surface block identifying methods, an integrated methodology framework was proposed and realized to analyze the stability of surface blocks in rock slopes. The surface blocks cut by geological structures, fissures or free faces could be identified subjected to the four principles of closure, completeness, uniqueness and validity. The factor of safety(FOS)of single key block was calculated by the limit equilibrium method. If there were two or more connected blocks, they were defined as a block-group. The FOS of a block-group was computed by the Sarma method. The proposed approach was applied to an actual rock slope of a hydropower project, and some possible instable blocks were demonstrated and analyzed visually. The obtained results on the key blocks or block-groups provide essential information for determining potential instable region of rock slopes and designing effective support scheme in advance.展开更多
liverrelated morbidity and mortality worldwide.It impacts nearly 300 million people.The current treatment for chronic infection with the hepatitis B virus(HBV)is complex and lacks a durable treatment response,especial...liverrelated morbidity and mortality worldwide.It impacts nearly 300 million people.The current treatment for chronic infection with the hepatitis B virus(HBV)is complex and lacks a durable treatment response,especially hepatitis B surface antigen(HBsAg)loss,necessitating indefinite treatment in most CHB patients due to the persistence of HBV covalently closed circular DNA(cccDNA).New drugs that target distinct steps of the HBV life cycle have been investigated,which comprise inhibiting the entry of HBV into hepatocytes,disrupting or silencing HBV cccDNA,modulating nucleocapsid assembly,interfering HBV transcription,and inhibiting HBsAg release.The achievement of a functional cure or sustained HBsAg loss in CHB patients represents the following approach towards HBV eradication.This review will explore the up-to-date advances in the development of new direct-acting anti-HBV drugs.Hopefully,with the combination of the current antiviral drugs and the newly developed direct-acting antiviral drugs targeting the different steps of the HBV life cycle,the ultimate eradication of CHB infection will soon be achieved.展开更多
针对岩体结构面发育特征的不确定性,提出一种岩质边坡异形滑动面搜索方法 .以Ⅲ,Ⅳ结构面岩体为研究对象,结合GeoSMA-3D(geotechnical structure and model analysis-3D)程序中块体切割和关键块体判别模块,将滑坡体设定为几何多面体.岩...针对岩体结构面发育特征的不确定性,提出一种岩质边坡异形滑动面搜索方法 .以Ⅲ,Ⅳ结构面岩体为研究对象,结合GeoSMA-3D(geotechnical structure and model analysis-3D)程序中块体切割和关键块体判别模块,将滑坡体设定为几何多面体.岩体的内部块体组合形成多面体,以多面体的表面表征滑动面.引入层次分析法,建立滑动面准定量化评价准则.以小盘岭边坡为例,将异形滑动面判定准则导入GeoSMA-3D程序中,研究表明边坡存在6个关键块体,组合滑动面有3个,潜在滑动面安全系数为1.046,滑动面几何形态与实际边坡拟合度高达95%,验证了岩质边坡滑动面搜索方法的合理性.展开更多
A new A-B-A type of block copolymers,polyacrylonitrile-block-polydimethylsiloxane-block-polyacrylonitrile（PAN-b-PDMSb-PAN）,which comprises two polymer blocks of different polarities and compatibilities,were synthesi...A new A-B-A type of block copolymers,polyacrylonitrile-block-polydimethylsiloxane-block-polyacrylonitrile（PAN-b-PDMSb-PAN）,which comprises two polymer blocks of different polarities and compatibilities,were synthesized for the first time via reversible addition-fragmentation chain transfer polymerization.Reaction kinetics was investigated.PAN-b-PDMS-b-PAN films were prepared by spin-coating on glass chips.Significant order on the film surface morphologies was observed.展开更多
From the results of researches of active faults in resent years, a correlation analysis between segments of the faults according to surface ruptures in nine historical strong earthquakes occurring in downfaulted syste...From the results of researches of active faults in resent years, a correlation analysis between segments of the faults according to surface ruptures in nine historical strong earthquakes occurring in downfaulted system and active structures around Ordos block is conducted in paper. The result shows that there is a good correlation between them, except few individual data that have more uncertain parameters. It shows that intensity and segments of surface ruptures in these strong earthquakes are intrinsically related with the active structures. These strong earthquakes produced stable and unstable rupture boundaries of characteristic-earthquake type and successive occurrence of strong earthquakes on the different boundary faults in the same tectonic unit.展开更多
以某轿车前后车门内板为例,探讨复杂钣金件的逆向设计过程和方法。通过手持式三维激光扫描仪的非接触式测量获取前后车门内板的点云数据。利用Geomagic Studio 12软件进行前期点云处理。基于CATIA V5 R17软件平台的自由曲面、创成式外...以某轿车前后车门内板为例,探讨复杂钣金件的逆向设计过程和方法。通过手持式三维激光扫描仪的非接触式测量获取前后车门内板的点云数据。利用Geomagic Studio 12软件进行前期点云处理。基于CATIA V5 R17软件平台的自由曲面、创成式外形设计、数字化外形编辑器、快速曲面重构等模块完成前后车门内板的曲面重构,并进行相应的曲面质量检查。对复杂钣金件的逆向建模流程和方法以及车门内板曲面质量的评价指标进行了相关探索。展开更多
基金Supported by the National Natural Science Foundation of China(No.51379006 and No.51321065)the Program for New Century Excellent Talents in University of Ministry of Education of China(NCET-12-0404)
文摘Complicated geological structures make it difficult to analyze the stability of rock slopes, such as faults, weak intercalated layers or joint fissures. Based on 3D geological modeling and surface block identifying methods, an integrated methodology framework was proposed and realized to analyze the stability of surface blocks in rock slopes. The surface blocks cut by geological structures, fissures or free faces could be identified subjected to the four principles of closure, completeness, uniqueness and validity. The factor of safety(FOS)of single key block was calculated by the limit equilibrium method. If there were two or more connected blocks, they were defined as a block-group. The FOS of a block-group was computed by the Sarma method. The proposed approach was applied to an actual rock slope of a hydropower project, and some possible instable blocks were demonstrated and analyzed visually. The obtained results on the key blocks or block-groups provide essential information for determining potential instable region of rock slopes and designing effective support scheme in advance.
文摘liverrelated morbidity and mortality worldwide.It impacts nearly 300 million people.The current treatment for chronic infection with the hepatitis B virus(HBV)is complex and lacks a durable treatment response,especially hepatitis B surface antigen(HBsAg)loss,necessitating indefinite treatment in most CHB patients due to the persistence of HBV covalently closed circular DNA(cccDNA).New drugs that target distinct steps of the HBV life cycle have been investigated,which comprise inhibiting the entry of HBV into hepatocytes,disrupting or silencing HBV cccDNA,modulating nucleocapsid assembly,interfering HBV transcription,and inhibiting HBsAg release.The achievement of a functional cure or sustained HBsAg loss in CHB patients represents the following approach towards HBV eradication.This review will explore the up-to-date advances in the development of new direct-acting anti-HBV drugs.Hopefully,with the combination of the current antiviral drugs and the newly developed direct-acting antiviral drugs targeting the different steps of the HBV life cycle,the ultimate eradication of CHB infection will soon be achieved.
文摘针对岩体结构面发育特征的不确定性,提出一种岩质边坡异形滑动面搜索方法 .以Ⅲ,Ⅳ结构面岩体为研究对象,结合GeoSMA-3D(geotechnical structure and model analysis-3D)程序中块体切割和关键块体判别模块,将滑坡体设定为几何多面体.岩体的内部块体组合形成多面体,以多面体的表面表征滑动面.引入层次分析法,建立滑动面准定量化评价准则.以小盘岭边坡为例,将异形滑动面判定准则导入GeoSMA-3D程序中,研究表明边坡存在6个关键块体,组合滑动面有3个,潜在滑动面安全系数为1.046,滑动面几何形态与实际边坡拟合度高达95%,验证了岩质边坡滑动面搜索方法的合理性.
基金supported by the National Natural Science Foundation of China (No. 20874057)the Key Natural Science Foundation of Shandong Province of China (No. ZR2011BZ001)
文摘A new A-B-A type of block copolymers,polyacrylonitrile-block-polydimethylsiloxane-block-polyacrylonitrile（PAN-b-PDMSb-PAN）,which comprises two polymer blocks of different polarities and compatibilities,were synthesized for the first time via reversible addition-fragmentation chain transfer polymerization.Reaction kinetics was investigated.PAN-b-PDMS-b-PAN films were prepared by spin-coating on glass chips.Significant order on the film surface morphologies was observed.
基金Chinese Joint Seismological Science Foundation.Contribution! No. 2000A005Institute of Crustal Dynamics, China Seismological
文摘From the results of researches of active faults in resent years, a correlation analysis between segments of the faults according to surface ruptures in nine historical strong earthquakes occurring in downfaulted system and active structures around Ordos block is conducted in paper. The result shows that there is a good correlation between them, except few individual data that have more uncertain parameters. It shows that intensity and segments of surface ruptures in these strong earthquakes are intrinsically related with the active structures. These strong earthquakes produced stable and unstable rupture boundaries of characteristic-earthquake type and successive occurrence of strong earthquakes on the different boundary faults in the same tectonic unit.
文摘以某轿车前后车门内板为例,探讨复杂钣金件的逆向设计过程和方法。通过手持式三维激光扫描仪的非接触式测量获取前后车门内板的点云数据。利用Geomagic Studio 12软件进行前期点云处理。基于CATIA V5 R17软件平台的自由曲面、创成式外形设计、数字化外形编辑器、快速曲面重构等模块完成前后车门内板的曲面重构,并进行相应的曲面质量检查。对复杂钣金件的逆向建模流程和方法以及车门内板曲面质量的评价指标进行了相关探索。
