Introduction: Good glycaemic control without causing excessive hypoglycaemia reduced the risk of macrovascular and microvascular complications in type 2 DM patients on regular haemodialysis (HD). The objectives of thi...Introduction: Good glycaemic control without causing excessive hypoglycaemia reduced the risk of macrovascular and microvascular complications in type 2 DM patients on regular haemodialysis (HD). The objectives of this study were to assess the efficacy and safety of add-on saxagliptin to insulin therapy in blood sugar control compared to insulin therapy alone in diabetic patients undergoing HD. Design and Methods: In this prospective open-labelled randomized controlled trial, HD patients with type 2 DM and on stable insulin therapy with HbA1c 7% - 13% were randomized to receive add-on saxagliptin 2.5 mg once daily to insulin therapy or insulin therapy only for 12 weeks. Results: 24 patients were randomized into each arm equally. Baseline and week-12 serum HbA1c, fructosamine, fasting blood glucose (FBS) and mean self monitoring blood glucose (SMBG) were comparable in the groups. Reduction of HbA1c and mean SMBG were significant in both groups. There was a significant drop in fructosamine levels (p = 0.004) and trend of lower FBS (p = 0.097) in add-on saxagliptin group but not in insulin alone group. The incidence of hypoglycaemia was the same in both groups. Conclusion: Add-on saxagliptin to insulin is comparable to insulin therapy alone in blood sugar control in regular HD patients and is safe and generally well tolerated. Add-on saxagliptin group may have more persistent and less fluctuation of glucose control compared to insulin only group.展开更多
Type 2 diabetic mellitus is a predominant metabolic disorder that has a direct impact on human health.Although scientific data are deficit,coconut jaggery has been suggested as a better alternative for cane sugar by s...Type 2 diabetic mellitus is a predominant metabolic disorder that has a direct impact on human health.Although scientific data are deficit,coconut jaggery has been suggested as a better alternative for cane sugar by some individuals.This study was conducted to assess the credibility of this claim.Coconut jaggery was prepared at Coconut Research Institute,Sri Lanka and nutritional composition of coconut jaggery was compared with cane sugar using standard methods.Significantly higher(P<0.05)moisture(8.92±0.22)%,ash(2.09±0.33)%,protein(1.91±0.28)%,fat(0.14±0.02)%and fiber(0.05±0.03)%contents were observed in coconut jaggery compared to cane sugar.The total starch and total sugar content of the coconut jaggery was significantly(P<0.05)lower than that of the cane sugar.Forty-three patients(Male:16,Female:27)with type 2 diabetes from the Endocrinology unit,National Hospital Colombo,Sri Lanka were voluntarily engaged in the study,subjected to an initial health screening.Then,determination of postprandial blood glucose responses after intake of the standard(glucose),cane sugar and coconut jaggery.Average age of the selected group was(48.19±7.95)years and they were all overweight(BMI>23.0).The mean fasting blood glucose level and HbA1c of the subjects were(149.05±54.88)mg/dL and(9.170±2.022)%,respectively.There was no significant difference(P>0.05)in peak blood glucose concentrations or incremental area under the curve in blood glucose response of two test food.Therefore,coconut jaggery cannot be considered as a healthy substitute for cane sugar in type 2 diabetic patients.展开更多
Type 2 diabetes mellitus(T2DM)is one of the fastest growing public health concerns around the world.Sugar-sweetened beverage(SSB)consumption has been proven to be associated with adverse health consequences in the dia...Type 2 diabetes mellitus(T2DM)is one of the fastest growing public health concerns around the world.Sugar-sweetened beverage(SSB)consumption has been proven to be associated with adverse health consequences in the diabetic population.Reducing SSB consumption,body weight control,healthy diets,and increased physical activity have been suggested as strategies to improve diabetes prevention and management.This literature review provides an overview of:(1)The association between SSB consumption and the risk of T2DM;(2)Types of SSB consumption and T2DM;(3)The effect of obesity and inflammation on the association between SSB consum-ption and risk of T2DM;and(4)SSB consumption in T2DM patients.There is still work to be done to determine how SSB consumption is related to T2DM,but the current research on identifying the association between SSB consumption and T2DM is promising,with the most promising studies confirming the connection between SSBs,T2DM risk,and diabetes management.Future studies should explore more effective SSB related diabetes prevention and management interventions.展开更多
文摘Introduction: Good glycaemic control without causing excessive hypoglycaemia reduced the risk of macrovascular and microvascular complications in type 2 DM patients on regular haemodialysis (HD). The objectives of this study were to assess the efficacy and safety of add-on saxagliptin to insulin therapy in blood sugar control compared to insulin therapy alone in diabetic patients undergoing HD. Design and Methods: In this prospective open-labelled randomized controlled trial, HD patients with type 2 DM and on stable insulin therapy with HbA1c 7% - 13% were randomized to receive add-on saxagliptin 2.5 mg once daily to insulin therapy or insulin therapy only for 12 weeks. Results: 24 patients were randomized into each arm equally. Baseline and week-12 serum HbA1c, fructosamine, fasting blood glucose (FBS) and mean self monitoring blood glucose (SMBG) were comparable in the groups. Reduction of HbA1c and mean SMBG were significant in both groups. There was a significant drop in fructosamine levels (p = 0.004) and trend of lower FBS (p = 0.097) in add-on saxagliptin group but not in insulin alone group. The incidence of hypoglycaemia was the same in both groups. Conclusion: Add-on saxagliptin to insulin is comparable to insulin therapy alone in blood sugar control in regular HD patients and is safe and generally well tolerated. Add-on saxagliptin group may have more persistent and less fluctuation of glucose control compared to insulin only group.
文摘Type 2 diabetic mellitus is a predominant metabolic disorder that has a direct impact on human health.Although scientific data are deficit,coconut jaggery has been suggested as a better alternative for cane sugar by some individuals.This study was conducted to assess the credibility of this claim.Coconut jaggery was prepared at Coconut Research Institute,Sri Lanka and nutritional composition of coconut jaggery was compared with cane sugar using standard methods.Significantly higher(P<0.05)moisture(8.92±0.22)%,ash(2.09±0.33)%,protein(1.91±0.28)%,fat(0.14±0.02)%and fiber(0.05±0.03)%contents were observed in coconut jaggery compared to cane sugar.The total starch and total sugar content of the coconut jaggery was significantly(P<0.05)lower than that of the cane sugar.Forty-three patients(Male:16,Female:27)with type 2 diabetes from the Endocrinology unit,National Hospital Colombo,Sri Lanka were voluntarily engaged in the study,subjected to an initial health screening.Then,determination of postprandial blood glucose responses after intake of the standard(glucose),cane sugar and coconut jaggery.Average age of the selected group was(48.19±7.95)years and they were all overweight(BMI>23.0).The mean fasting blood glucose level and HbA1c of the subjects were(149.05±54.88)mg/dL and(9.170±2.022)%,respectively.There was no significant difference(P>0.05)in peak blood glucose concentrations or incremental area under the curve in blood glucose response of two test food.Therefore,coconut jaggery cannot be considered as a healthy substitute for cane sugar in type 2 diabetic patients.
文摘Type 2 diabetes mellitus(T2DM)is one of the fastest growing public health concerns around the world.Sugar-sweetened beverage(SSB)consumption has been proven to be associated with adverse health consequences in the diabetic population.Reducing SSB consumption,body weight control,healthy diets,and increased physical activity have been suggested as strategies to improve diabetes prevention and management.This literature review provides an overview of:(1)The association between SSB consumption and the risk of T2DM;(2)Types of SSB consumption and T2DM;(3)The effect of obesity and inflammation on the association between SSB consum-ption and risk of T2DM;and(4)SSB consumption in T2DM patients.There is still work to be done to determine how SSB consumption is related to T2DM,but the current research on identifying the association between SSB consumption and T2DM is promising,with the most promising studies confirming the connection between SSBs,T2DM risk,and diabetes management.Future studies should explore more effective SSB related diabetes prevention and management interventions.
