N,N-Bis(2-pyridylmethyl)-amine-N-ethyl-2-pyridine-2-carboxamide was synthesized and characterized according to the literature. At 25 ℃, I=0.1 mol/L KNO 3, the stability constants of the binary system formed by the li...N,N-Bis(2-pyridylmethyl)-amine-N-ethyl-2-pyridine-2-carboxamide was synthesized and characterized according to the literature. At 25 ℃, I=0.1 mol/L KNO 3, the stability constants of the binary system formed by the ligand with metal ions in ethanol aqueous solution were studied by pH potentiometric titration and the appropriate structures with respect to the titration species were proposed. The results show that the stability order of divalent metals binding to the ligand is Co<Ni>Cu<Zn which does not conform to the order of the Irving-Williams series. Then the abnormal property of copper complex is discussed.展开更多
By means of acid-base potentiometric titration and the advanced BEST computer program developed by Martell et al., the deprotonation constants of four inhibitors[Aminotrimethylenephosphoinic acid(ATMP), 2-phosphino-tu...By means of acid-base potentiometric titration and the advanced BEST computer program developed by Martell et al., the deprotonation constants of four inhibitors[Aminotrimethylenephosphoinic acid(ATMP), 2-phosphino-tutane-1,2,4-tricarboxylic acid(PBTCA), polyacrylic acid(PAA, M_w=2000), poly(maleic, acrylic) acid(PMAAA, M_w=3000)], and the stability constants of the complexes of these inhibitors with Ca 2+ have been determined. And the distribution curves of ATMP at different pH values in aqueous solutions have also been given out. The result of this study can be applied to explaining the inhibition mechanism.展开更多
THE mechanism of the action of the classic platinum antitumor drugs can be interpreted accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replic...THE mechanism of the action of the classic platinum antitumor drugs can be interpreted accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replication. Recently, it was found that a new class of compounds withthe general formula cis-[Pt（NH<sub>3</sub>）<sub>2</sub>（N-het）Cl]Cl（N-het is a heteroaromatic N-base like pyri-dine） show effective antitumor activities. However, two possible mechanisms of action展开更多
文摘N,N-Bis(2-pyridylmethyl)-amine-N-ethyl-2-pyridine-2-carboxamide was synthesized and characterized according to the literature. At 25 ℃, I=0.1 mol/L KNO 3, the stability constants of the binary system formed by the ligand with metal ions in ethanol aqueous solution were studied by pH potentiometric titration and the appropriate structures with respect to the titration species were proposed. The results show that the stability order of divalent metals binding to the ligand is Co<Ni>Cu<Zn which does not conform to the order of the Irving-Williams series. Then the abnormal property of copper complex is discussed.
文摘By means of acid-base potentiometric titration and the advanced BEST computer program developed by Martell et al., the deprotonation constants of four inhibitors[Aminotrimethylenephosphoinic acid(ATMP), 2-phosphino-tutane-1,2,4-tricarboxylic acid(PBTCA), polyacrylic acid(PAA, M_w=2000), poly(maleic, acrylic) acid(PMAAA, M_w=3000)], and the stability constants of the complexes of these inhibitors with Ca 2+ have been determined. And the distribution curves of ATMP at different pH values in aqueous solutions have also been given out. The result of this study can be applied to explaining the inhibition mechanism.
文摘THE mechanism of the action of the classic platinum antitumor drugs can be interpreted accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replication. Recently, it was found that a new class of compounds withthe general formula cis-[Pt（NH<sub>3</sub>）<sub>2</sub>（N-het）Cl]Cl（N-het is a heteroaromatic N-base like pyri-dine） show effective antitumor activities. However, two possible mechanisms of action
